Gastric B-Cell Lymphoma with Mott Cell Differentiation in a Dog

Zan, Gabrita De; Zappulli, Valentina; Cavicchioli, Laura; Martino, Linda Di; Ros, Eriberta; Conforto, Giorgia; Castagnaro, Massimo

doi:10.1177/104063870902100521

Cited by 21 publications

(35 citation statements)

References 13 publications

(43 reference statements)

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“…Mott cell differentiation characterizes a rare subtype of B‐cell lymphoma, which has been reported previously in only 6 dogs and a ferret . The neoplastic cells in the lymph nodes of the dog described here had unusual bimorphism in cytologic specimens, and lymphocyte morphology differed markedly from that in the peripheral blood, requiring further histologic and immunophenotypic evaluation.…”

Section: Discussionmentioning

confidence: 55%

B‐cell lymphoma with plasmacytoid differentiation, atypical cytoplasmic inclusions, and secondary leukemia in a dog

Kol

Christopher

Skorupski

et al. 2012

Veterinary Clinical Pathol

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A 7-year-old male castrated Jack Russell Terrier was presented to the oncology service at the University of California-Davis Veterinary Medical Teaching Hospital for evaluation of suspected lymphoma. The dog had several enlarged lymph nodes and moderate lymphocytosis. Aspirates of an enlarged inguinal lymph node contained a bimorphic population of large immature lymphocytes and smaller cells with plasmacytoid features. Both cell types often contained a single large cytoplasmic inclusion that varied from clear to pale pink to sky blue. Cytologic changes were interpreted as most consistent with lymphoid neoplasia. Based on the predominantly mature cell morphology and some morphologic heterogeneity, the peripheral lymphocytosis was interpreted as most likely reactive in nature. However, the immunophenotype of the cells (CD20+, CD21+, CD79a+, MUM-1+, and MHCII+) and clonality assays showed that tissue and blood lymphocytes were neoplastic B cells with clonal identity despite their different morphologic appearances. The cytoplasmic inclusions were positive with periodic acid-Schiff and were immunoreactive for IgM and IgG. By transmission electron microscopy, inclusions consisted of aberrant rough endoplasmic reticulum; a few small Russell bodies were also noted. A final diagnosis of high-grade B-cell lymphoma with plasmacytoid differentiation, atypical cytoplasmic inclusions, and secondary leukemia was made. Chemotherapy was initiated, but the dog was euthanized due to severe and uncontrolled seizures 9 months after the initial diagnosis. This case extends the morphologic repertoire of canine plasmacytoid neoplasms and emphasizes their continuum with multicentric lymphoma. This case also demonstrates the need for advanced diagnostic techniques in establishing blood involvement in lymphoma in some instances.

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Section: Discussionmentioning

confidence: 55%

B‐cell lymphoma with plasmacytoid differentiation, atypical cytoplasmic inclusions, and secondary leukemia in a dog

Kol

Christopher

Skorupski

et al. 2012

Veterinary Clinical Pathol

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“…6,16,24 These cases primarily involved the gastrointestinal tract and lymph nodes 6,16,24 ; a single case had multiple nodules in spleen, liver, and lung. 6,16,24 In contrast, the gastrointestinal tract was not affected in the ferret in the current report; however, marked splenomegaly, generalized lymphadenomegally, and scattered white nodules in the liver were present. Benign plasma cell neoplasms in dogs and cats are usually irregularly positive for lambda and kappa light chains.…”

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confidence: 99%

Malignant B-Cell Lymphoma with Mott Cell Differentiation in a Ferret (Mustela Putorius Furo)

et al. 2010

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Abstract. A 3.5-year-old, male, neutered ferret (Mustela putorius furo) was presented with a 3-day history of lethargy and anorexia. Splenic aspirates revealed high numbers of intermediate-sized lymphocytes and Mott cells interpreted as lymphoma with Mott cells. The ferret was euthanized because of a poor clinical prognosis. Postmortem examination revealed markedly enlarged spleen and lymph nodes, with multifocal white nodules in the liver parenchyma. Histologically, the spleen had multifocal large nodules composed of neoplastic lymphocytes with frequent Mott cells. Similar neoplastic cells were present in the sections of liver, lymph nodes, and bone marrow. These cells were cluster of differentiation (CD)3-negative, CD79a-positive, and lambda light-chain-positive. Electron microscopy revealed that the cytoplasm of the neoplastic Mott cells had increased, disorganized, dilated, rough endoplasmic reticulum containing electron-dense immunoglobulin. On the basis of cytologic, histopathologic, immunohistochemical, and electron microscopic findings, a malignant B-cell lymphoma with Mott cell differentiation was diagnosed.

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“…Furthermore, three cases of gastrointestinal Mott cell tumor have been previously reported in veterinary medicine (11,12,13). Signet ring cell adenocarcinoma of the canine stomach is characterised by a diffuse infiltration of signet ring tumour cells in the gastric wall.…”

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confidence: 99%

“…In dogs, these are rare neoplastic conditions, described as solid, multiple masses, characterized by the frequent presence of distant metastases at time of diagnosis (13). Additionally, in these neoplastic conditions Mott cells and Rbs are usually found in small numbers among a larger population of polymorphous lymphocytic infiltrate (13).…”

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confidence: 99%

Chronic gastrointestinal inflammation in a dog mimicking human russell body gastroduodenitis

Cervone¹,

Duboy²,

Laprie³

et al. 2017

Braz. J. Vet. Pathol.

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Cervone, et al.; Chronic gastrointestinal inflammation in a dog mimicking human russell body gastroduodenitis. Braz J Vet Pathol, 2017, 10(3), 100 -104 DOI: 10.24070/bjvp.1983-0246.v10i3p100-104 AbstractHerein we describe an unusual benign chronic gastroduodenal inflammation associated with protein losing enteropathy in a dog. A 10-year-old Golden Retriever dog was presented for chronic weight loss associated with pica, ptyalism, vomiting and diarrhea. Blood chemistry showed hypoproteinaemia and hypoalbuminaemia. Gastric and duodenal full-thickness biopsies were collected and histopathological examination revealed severe mucosal infiltration with Mott cells, consistent with Russell body gastroduodenitis in humans. Warthin-starry stain showed no Helicobacter spp. proliferation in gastric biopsies. After treatment including anti-acid, antibiotics and corticosteroids, no recurrence of gastrointestinal signs was reported and improvement in clinical and biological condition was observed.

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Gastric B-Cell Lymphoma with Mott Cell Differentiation in a Dog

Cited by 21 publications

References 13 publications

B‐cell lymphoma with plasmacytoid differentiation, atypical cytoplasmic inclusions, and secondary leukemia in a dog

B‐cell lymphoma with plasmacytoid differentiation, atypical cytoplasmic inclusions, and secondary leukemia in a dog

Malignant B-Cell Lymphoma with Mott Cell Differentiation in a Ferret (Mustela Putorius Furo)

Chronic gastrointestinal inflammation in a dog mimicking human russell body gastroduodenitis

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