Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway

Wu, Shih Ying; Wang, Tzu Feng; Yu, Lung; Jen, Chauying J.; Chuang, Jih Ing; Wu, Fong Sen; Wu, Chun Ying; Kuo, Yu Min

doi:10.1016/j.bbi.2010.09.006

Cited by 172 publications

(127 citation statements)

References 74 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Animals in each group respectively received a single acute dose of K252a (1 μmol/L for 1 μL, intracerebroventricular (ICV) infusion), U0126 (10 μmol in 2 μL for ICV infusion), LY294002 (10 μmol in 2 μL for ICV infusion), or vehicle (DMSO) 30 min before 7-CTKA or vehicle injection according to the above-mentioned instructions for six groups. These doses were chosen based on previous reports demonstrating selective and effective inhibition of the corresponding targets (Wu et al 2011;Cota et al 2006;Sui et al 2008). Each animal was handled exactly the same as every other animals in the study except for the specific drug treatment it was receiving.…”

Section: Cums Proceduresmentioning

confidence: 99%

7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Cums Proceduresmentioning

confidence: 99%

7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress

et al. 2014

View full text Add to dashboard Cite

show abstract

“…59 One other animal model utilized systemically administered lipopolysaccharide to induce nigral cell loss and parkinsonism; exercise blocked these negative outcomes in proportion to the exercise duration, apparently mediated by elevated BDNF levels. 60 Other exercise effects in parkinsonian animal models have included enhanced subventricular zone neural progenitor cell proliferation and migration, 47 as well as reversal of age-related decline in substantia nigra vascularization, apparently mediated by vascular endothelial growth factor (VEGF) expression. How such animal models relate to neurodegenerative PD is open to debate.…”

Section: Animal Modelsmentioning

confidence: 99%

Does vigorous exercise have a neuroprotective effect in Parkinson disease?

2011

View full text Add to dashboard Cite

Parkinson disease (PD) is progressive, with dementia and medication-refractory motor problems common reasons for late-stage nursing-home placement. Increasing evidence suggests that ongoing vigorous exercise/physical fitness may favorably influence this progression. Parkinsonian animal models reveal exercise-related protection from dopaminergic neurotoxins, apparently mediated by brain neurotrophic factors and neuroplasticity (predicted from in vitro studies). Similarly, exercise consistently improves cognition in animals, also linked to enhanced neuroplasticity and increased neurotrophic factor expression. In these animal models, immobilization has the opposite effect. Brain-derived neurotrophic factor (BDNF) may mediate at least some of this exercise benefit. In humans, exercise increases serum BDNF, and this is known to cross the blood-brain barrier. PD risk in humans is significantly reduced by midlife exercise, documented in large prospective studies. No studies have addressed whether exercise influences dementia risk in PD, but exercised patients with PD improve cognitive scores. Among seniors in general, exercise or physical fitness has not only been associated with better cognitive scores, but midlife exercise significantly reduces the later risk of both dementia and mild cognitive impairment. Finally, numerous studies in seniors with and without dementia have reported increased cerebral gray matter volumes associated with physical fitness or exercise. These findings have several implications for PD clinicians. 1) Ongoing vigorous exercise and physical fitness should be highly encouraged. 2) PD physical therapy programs should include structured, graduated fitness instruction and guidance for deconditioned patients with PD. 3) Levodopa and other forms of dopamine replenishment therapy should be utilized to achieve the maximum capability and motivation for patients to maintain fitness. Neurology Parkinson disease (PD) is progressive. Although the dopaminergic nigrostriatal system receives much attention, progression in nondopaminergic circuits eventually becomes the primary substrate for major PD disability. Nursing home placement is typically the consequence of cognitive impairment/dementia or nondopaminergic motor deficits, especially levodopa-refractory balance and gait problems. 1A major focus of PD research has been on "disease-modifying" or "neuroprotective" agents to slow PD progression. No drugs have surfaced, to date, that unequivocally have that property. However, often overlooked in this discussion is the potential benefit of sustained vigorous exercise on PD progression. Exercise is well-known to have general health benefits, including improvement of cardiovascular and cerebrovascular health, reduction of osteoporosis/fracture risk and age-related sarcopenia, improvement of psychological affect, and perhaps even a general anti-inflammatory effect.2 However, accumulating evidence, albeit indirect, suggests that ongoing vigorous exercise may have a neuroprotective effect in PD, beyond th...

show abstract

“…Evidence suggests that BDNF may be involved in the beneficial effect of cardiopulmonary fitness on cognitive performance. In the central nervous system, BDNF can support neuronal growth and survival (Berchtold et al, 2010) and attenuate inflammatory damage to axons and midbrain dopaminergic neurons (Fujino et al, 2009;Katsuki et al, 2009;Linker et al, 2010;Wu et al, 2011). In medically and neurologically healthy older adults, higher serum BDNF protein concentrations have been variably associated with better cognitive performance (Gunstad et al, 2008;Komulainen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease

Swardfager

Herrmann

Marzolini

et al. 2011

Brain, Behavior, and Immunity

View full text Add to dashboard Cite

Objective-To assess serum brain derived neurotrophic factor (BDNF) concentrations as a correlate of cardiopulmonary fitness and as a predictor of cognitive performance in subjects with coronary artery disease (CAD). Methods-Serum CIHR Author Manuscript CIHR Author Manuscript CIHR Author ManuscriptVerbal Learning Test 2nd Ed., Stroop, Trail Making Test B and the Digit Symbol-Coding task were administered. The val66met BDNF genotype and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations were determined as potential confounders.Results-In subjects with CAD (n = 88; 85.2% male, mean age 62.8 ± 10.5 yr), cardiopulmonary fitness was associated with higher serum BDNF concentrations (β = .305, p = .013). Higher serum BDNF concentrations were associated with higher MMSE scores (F(1, 87) = 15.406, p < .0005) and better performance on the Digit Symbol-Coding task (F(1, 87) = 9.620, p = .003). IL-6, TNF-α and the val66met genotype did not influence these results.Conclusion-Serum BDNF concentrations were associated with cardiopulmonary fitness, psychomotor processing speed and overall cognition in subjects with CAD.

show abstract

Running exercise protects the substantia nigra dopaminergic neurons against inflammation-induced degeneration via the activation of BDNF signaling pathway

Cited by 172 publications

References 74 publications

7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress

7-Chlorokynurenic acid (7-CTKA) produces rapid antidepressant-like effects: through regulating hippocampal microRNA expressions involved in TrkB-ERK/Akt signaling pathways in mice exposed to chronic unpredictable mild stress

Does vigorous exercise have a neuroprotective effect in Parkinson disease?

Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease

Contact Info

Product

Resources

About