2011
DOI: 10.1212/wnl.0b013e318225ab66
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Does vigorous exercise have a neuroprotective effect in Parkinson disease?

Abstract: Parkinson disease (PD) is progressive, with dementia and medication-refractory motor problems common reasons for late-stage nursing-home placement. Increasing evidence suggests that ongoing vigorous exercise/physical fitness may favorably influence this progression. Parkinsonian animal models reveal exercise-related protection from dopaminergic neurotoxins, apparently mediated by brain neurotrophic factors and neuroplasticity (predicted from in vitro studies). Similarly, exercise consistently improves cognitio… Show more

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Cited by 383 publications
(286 citation statements)
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“…Given that time is perceived to be one of the main barriers to regular physical activity [9,10], vigorous exercise has a clear advantage over moderate-intensity exercise as a way to meet the current physical activity guidelines. There is also growing physiological and epidemiological evidence that vigorous exercise may be essential to maximise the benefits of physical activity [15][16][17][18]. Therefore, I believe it is worthwhile to find ways to facilitate vigorous exercise in the general population so that it is not limited to relatively few athletes and fitness enthusiasts.…”
Section: Humans Are Inherently ''Lazy''mentioning
confidence: 99%
“…Given that time is perceived to be one of the main barriers to regular physical activity [9,10], vigorous exercise has a clear advantage over moderate-intensity exercise as a way to meet the current physical activity guidelines. There is also growing physiological and epidemiological evidence that vigorous exercise may be essential to maximise the benefits of physical activity [15][16][17][18]. Therefore, I believe it is worthwhile to find ways to facilitate vigorous exercise in the general population so that it is not limited to relatively few athletes and fitness enthusiasts.…”
Section: Humans Are Inherently ''Lazy''mentioning
confidence: 99%
“…Prevention:Exercise in the middle age reduces the risk of Parkinson's disease later in life [71].Caffeine also appears protective with greater decrease in risk occurring with larger intake of caffeinated beverages such as coffee [72].Although tobacco smoke causes adverse health effects, decreases life expectancy and quality of life, it may reduce the risk of PD a third when compared to nonsmokers[11t].The basis of this effect is not known, but possibilities include as effect of nicotine as a dopamine stimulant [11].Antioxidants, such as vitamins C and D, have been proposed to protect against the disease, but results of studies have been contradictory and no positive effect has been proven [11].Also there have been preliminary indications of possible protective role of estrogens and anti-inflammatory drugs [11].…”
Section: Management Prognosis and Preventionmentioning
confidence: 99%
“…Moreover, emerging literature suggests that staying physically active may actually have a favorable influence on brain integrity and neuroplasticity, possibly neuroprotective in PD. 17 5. geNeric immeDiAte-releAse 25/100 cArbiDoPA/ levoDoPA is AN excelleNt choice Carbidopa/levodopa dosage is given as 2 numbers, with the first representing the carbidopa component. Carbidopa protects against nausea, and hence formulations with more carbidopa are usually preferable and only slightly more expensive (ie, 25/100 vs 10/100).…”
Section: Dopamine Replenishment Remains the Key To Symptomatic Treatmentmentioning
confidence: 99%