Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease

Abstract

Objective-To assess serum brain derived neurotrophic factor (BDNF) concentrations as a correlate of cardiopulmonary fitness and as a predictor of cognitive performance in subjects with coronary artery disease (CAD). Methods-Serum CIHR Author Manuscript CIHR Author Manuscript CIHR Author ManuscriptVerbal Learning Test 2nd Ed., Stroop, Trail Making Test B and the Digit Symbol-Coding task were administered. The val66met BDNF genotype and serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) concentrations were determined as potential confounders.Results-In subjects with CAD (n = 88; 85.2% male, mean age 62.8 ± 10.5 yr), cardiopulmonary fitness was associated with higher serum BDNF concentrations (β = .305, p = .013). Higher serum BDNF concentrations were associated with higher MMSE scores (F(1, 87) = 15.406, p < .0005) and better performance on the Digit Symbol-Coding task (F(1, 87) = 9.620, p = .003). IL-6, TNF-α and the val66met genotype did not influence these results.Conclusion-Serum BDNF concentrations were associated with cardiopulmonary fitness, psychomotor processing speed and overall cognition in subjects with CAD.

996. The Effect of Exercise Training on Resting Concentrations of Peripheral Brain-derived Neurotrophic Factor (BDNF): A Meta-analysis

“…Increased resting peripheral BDNF concentrations may indicate an increase in central BDNF production [120][121][122][123]. Increased BDNF production in the CNS may result in enhanced synaptogenesis and neuronal survival, resulting in structural changes and enhanced cognition [20,22,[124][125][126][127]. While the findings support the hypothesis that BDNF concentration is increased in the blood after an exercise training intervention, it cannot be inferred that BDNF concentration is increased in the brain.…”

Genetics of serum BDNF: Meta-analysis of the Val66Met and genome-wide association study

“…In addition to the data from the SardiNIA sample, we identified 11 articles for inclusion in the meta-analysis (Bhang et al , 2011, Duncan et al , 2009, Elzinga et al , 2011, Forlenza et al , 2010, Lang et al , 2009, Minelli et al , in press, Ozan et al , 2010, Swardfager et al , 2011, Yoshimura et al , 2011, Yu et al , 2008, Zhang et al , 2008), for a total of k = 13 independent samples, ranging in size from 27 to 2054, and for a total of 4727 subjects (2351 Met carriers and 2376 Val/Val carriers). The mean and SD of serum BDNF for each sample included in the meta-analysis are reported in supplementary Table 1.…”

A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise

“…Previous findings suggest that certain cognitive domains, such as processing speed and attention[64, 65], may be more amenable to exercise effects; however, effects of exercise on cognition have not been consistent[66]. While adaptations to exercise are incompletely understood, they are associated with markers of neurogenesis and angiogenesis in patients with CAD[67]. These processes may underlie increases in gray and white matter volumes[31, 68] as well as cerebral blood flow[69, 70], which may partly mediate exercise-induced cognitive improvement[71, 72].…”