Rumex alveollatus hydroalcoholic extract protects CCL4-induced hepatotoxicity in mice

Naseri, Leila; Khazaei, Mozafar; Ghanbari, Elham; Bazm, Mohsen Akbari

doi:10.1007/s00580-018-2846-7

Cited by 13 publications

(13 citation statements)

References 22 publications

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“…Although the intracellular antioxidant system of spermatozoa is at its threshold ability to fight the ROS, but with the addition of exogenous antioxidants can increase this ability. Dietary antioxidants act synergistically with the endogenous antioxidants to prevent diseases via restoring the ROS homeostasis(Naseri et al, 2019). In the present study, the groups treated with L. casei and L. coagulans (especially L. casei) revealed high antioxidant capacity evidenced by decreased MDA levels and increased CAT and SOD activities.…”

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confidence: 47%

The ameliorative effects of Lactobacillus coagulans and Lactobacillus casei probiotics on CCl4‐induced testicular toxicity based on biochemical, histological and molecular analyses in rat

et al. 2020

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According to the World Health Organization (WHO), infertility means the inability of a sexually active and not on contraception couple to achieve pregnancy within 1 year (Murray et al., 2012). According to global epidemiological reports, approximately 15% of all people who are in reproductive age suffer from this disorder. Over the past decade, about 50 per cent of male infertility cases have been due to reproductive disorders and reduced sperm quality (Patel et al., 2018). Reactive oxygen species (ROS) play a critical role in sperm maturation and function, as well as male fertilisation (Wagner et al., 2018). A balance between ROS production and elimination is necessary for spermatozoa to remain physiologically active. According to studies, some groups containing oxygen radicals such as H 2 O 2 , hydroxyl (•OH) and peroxyl (•ROO −) radicals, and superoxide (•O 2−) play essential roles in male infertility. The peroxidation of unsaturated membrane fatty acids in testes increases the production of free radicals and induces apoptosis in testicular

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supporting

confidence: 47%

The ameliorative effects of Lactobacillus coagulans and Lactobacillus casei probiotics on CCl4‐induced testicular toxicity based on biochemical, histological and molecular analyses in rat

et al. 2020

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“…Cat no. 1442125) and final solution was stored at 4°C in dry and dark condition until use (Naseri et al., 2019).…”

Section: Methodsmentioning

confidence: 99%

Immunomodulatory effects of bee pollen on doxorubicin‐induced bone marrow/spleen immunosuppression in rat

et al. 2021

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“…2 UK) then the solution was condensed by a vacuum distillation unit (Heidolph Collegiate, LABOROTA 4000) at 50°C. The final dried extract (20 g) was stored at 4°C (Naseri, Khazaei, Ghanbari, & Bazm, 2019).…”

Section: Extract Preparationmentioning

confidence: 99%

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

et al. 2020

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Anabolic androgenic steroids (AAS) such as oxymetholone (OM) used for athletic enhancement, but increased free radicals damage and changes in hormonal levels, lead to serious and irreversible organ damage. Vaccinium arctostaphylos(V. arctostaphylos( has been demonstrated to have antioxidant and antiinflammatory effects. The aim of present study was to investigate V. arctostaphylos effect on OM‐induced oxidative injury in mouse testis and sperm parameters. In this experimental study, 30 BALB/c mice were divided into five groups, including healthy, positive control(5 mg/kg OM) and three treatment groups (100, 200 and 400 mg/kg of V. arctostaphylos extract + 5 mg/kg OM). At the end of the study, serum luteinizing hormone (LH), follicle‐stimulating hormone (FSH) and testosterone levels were measured. Testis stereological and sperm parameters were calculated. Antioxidant status was measured using nitric oxide (NO) and FRAP assay, and malondialdehyde (MDA) levels. Furthermore, the expression of p53, caspase‐3, Bax and Bcl‐2 was measured. V. arctostaphylos decreased the serum level of testosterone, increased the LH and FSH, and improved the stereological and sperm parameters and down‐regulated the p53, caspase‐3 and Bax and up‐regulated Bcl‐2 genes. Furthermore, this dose decreased serum levels of NO and increased testis FRAP and MDA levels in treated groups compared with OM group. V. arctostaphylos extract has protective effects against testicular toxicity caused by OM.

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Rumex alveollatus hydroalcoholic extract protects CCL4-induced hepatotoxicity in mice

Cited by 13 publications

References 22 publications

The ameliorative effects of Lactobacillus coagulans and Lactobacillus casei probiotics on CCl4‐induced testicular toxicity based on biochemical, histological and molecular analyses in rat

The ameliorative effects of Lactobacillus coagulans and Lactobacillus casei probiotics on CCl4‐induced testicular toxicity based on biochemical, histological and molecular analyses in rat

Immunomodulatory effects of bee pollen on doxorubicin‐induced bone marrow/spleen immunosuppression in rat

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

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