RPTOR methylation in the peripheral blood and breast cancer in the Chinese population

Yin, Yifei; Lei, Shuifang; Li, Lixi; Yang, Xiaoqin; Yin, Qiming; Tian, Xu; Zhou, Wenjie; Li, Hong; Gu, Wanjian; Ma, Fei; Yang, Rongxi; Zhang, Zhengdong

doi:10.1007/s13258-021-01182-0

Cited by 4 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data revealed that DNA methylation was related to the clinical characteristics of BC, consistent with our previous studies ( Lei et al, 2021 ; Yin et al, 2022 ). Here we found significantly lower methylation of CD160 , ISYNA1 and RAD51B were correlated with hormone receptor status, increased breast tumor size, advanced tumor stage and more lymph node involvement.…”

Section: Discussionsupporting

confidence: 92%

The Association Between Breast Cancer and Blood-Based Methylation of CD160, ISYNA1 and RAD51B in the Chinese Population

et al. 2022

Self Cite

View full text Add to dashboard Cite

Recent studies have identified DNA methylation signatures in the white blood cells as potential biomarkers for breast cancer (BC) in the European population. Here, we investigated the association between BC and blood-based methylation of cluster of differentiation 160 (CD160), inositol-3-phosphate synthase 1 (ISYNA1) and RAD51 paralog B (RAD51B) genes in the Chinese population. Peripheral blood samples were collected from two independent case-control studies with a total of 272 sporadic early-stage BC cases (76.5% at stage I&II) and 272 cancer-free female controls. Mass spectrometry was applied to quantitatively measure the levels of DNA methylation. The logistic regression and non-parametric tests were used for the statistical analyses. In contrast to the protective effects reported in European women, we reported the blood-based hypomethylation in CD160, ISYNA1 and RAD51B as risk factors for BC in the Chinese population (CD160_CpG_3, CD160_CpG_4/cg20975414, ISYNA1_CpG_2, RAD51B_CpG_3 and RAD51B_CpG_4; odds ratios (ORs) per -10% methylation ranging from 1.08 to 1.67, p < 0.05 for all). Moreover, hypomethylation of CD160, ISYNA1 and RAD51B was significantly correlated with age, BC subtypes including estrogen receptor (ER)-negative BC tumors, triple negative tumors, BC cases with larger size, advanced stages and more lymph node involvement. Our results supported the report in European women that BC is associated with altered methylation of CD160, ISYNA1 and RAD51B in the peripheral blood, although the effects are opposite in the Chinese population. The difference between the two populations may be due to variant genetic background or life styles, implicating that the validations of epigenetic biomarkers in variant ethnic groups are warranted.

show abstract

Section: Discussionsupporting

confidence: 92%