Mannose: a potential saccharide candidate in disease management

Dhanalakshmi, M.; Sruthi, D.; Jinuraj, K R; Das, Kajari; Dave, Sushma; Andal, N. Muthulakshmi; Das, Jayashankar

doi:10.1007/s00044-023-03015-z

Cited by 29 publications

(8 citation statements)

References 176 publications

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“…As previously noted, numerous studies indicate that the effectiveness of MOS bioactivities is closely linked to its degree of hydrolysis, especially when the degree of polymerization (DP) is below 6. Additionally, while mannose offers health benefits [36], maximizing its extraction was not the primary focus of this study; instead, the focus was on maximizing MOS production.…”

Section: Modeling and Influence Of Design Parameters On Mos Productio...mentioning

confidence: 99%

Production of Mannooligosaccharides from Açaí Seed by Immobilized β-Mannanase

Murillo-Franco,

Galvis-Nieto,

Orrego

2024

Processes

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In this work, an enzyme cocktail with β-mannanase as the main activity was immobilized on epoxy resin foams filled with fibers from annatto capsules. The catalytic system was characterized by SEM, FTIR, and a mechanical crush resistance test. The behavior of the pH and temperature for the hydrolysis of the locust bean gum were also studied. With the same substrate and with respect to the free enzyme, the immobilized enzyme showed an activity retention of 79.61%. Its operational stability in ten reuse cycles did not show any statistically significant loss of activity. This catalytic system was used to study the preferential release of MOS of two to five degrees of polymerization from mannan present in dried and ground açaí seeds, which were not subjected to any other pretreatment. Using an experimental response surface design, the predicted quadratic models for the M2–M5 MOS content were obtained and they fit well with the experimental data, predicting a production range between 0.435 and 20 g/L of MOS (M2–M5). In addition, the production reached about 12 g/L under the optimized conditions. These results indicate that the used foamed epoxy resin supports and immobilization methodology are suitable for catalyzing the hydrolysis of mannan from açaí seeds.

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Section: Modeling and Influence Of Design Parameters On Mos Productio...mentioning

confidence: 99%

Production of Mannooligosaccharides from Açaí Seed by Immobilized β-Mannanase

Murillo-Franco,

Galvis-Nieto,

Orrego

2024

Processes

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“…D-mannose not only downregulates gut dysbiosis by enhancing intestinal barrier integrity [150,151] but also suppresses the adipokine and cytokine triad (TNF-α, IL-6, IL-1β) [156][157][158], linked to cancer [159,160], cardiovascular disease [161], stroke [162], obesity [163], diabetes [164], neurodegenerative disease [165], and autoimmune disease [166,167]. D-mannose suppresses autoimmune diseases, e.g., T1DM, asthma, and SLE [168] by suppressing IFN-γ [39,113]. D-mannose can suppress ERK (extracellular signal regulated kinase) signaling pathways (see Figure 3) [169] integral to TGF-β induced organ fibrosis [170], transformation of fibroblasts into CAFs [171], epithelial/endothelial mesenchymal transformation (EMT) [172], and VEGF synthesis [173].…”

Section: B Triple Playmentioning

confidence: 99%

Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (POTS), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play

Chambers

2024

Preprint

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“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via the gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. A dysbiotic gut microbiome, low in biodiversity and butyrate producers, alters tryptophan metabolism with release of proinflammatory cytokines, predominantly TNF-α, IL-6, and IL-1β. These also characterize chronic inflammation, oxidative stress, and a multitude of diseases, all exhibiting low HRV. Gut dysbiosis upregulates IFN-γ and with it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to that of IDO induced kynurenine, increasing the kynurenine to tryptophan ratio (KTR). An elevated KTR is positively linked to neurodegenerative and autoimmune diseases and negatively linked to HRV. Elevated IDO activity is not only enzymatic but also an intracellular signal transducer potentiated by TGF-β. This cytokine is the primary determinant of the TME. Also proposed is the gut-lung dysbiosis concept and consequent degradation of ACE2 (richest in lungs and gut). Leaky gut induced autoantibodies related to G-protein coupled receptors (GPCRs) in combination with increased Ang II further potentiate oxidative stress. Aldosterone and paroxysmal orthostatic tachycardia syndrome (POTS) paradoxes are highlighted in the context of GPCR and gut dysbiosis, and the role of Candida is explored. The triple play of a prebiotic (d-mannose), probiotic (bifidobacteria and lactobacilli), and postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry of GPCR antigens, suppress the inflammatory cytokine triad, balance IFN-γ and TGF-β, suppress oxidative stress, depress KTR, elevate HRV, and extend lifespan and its quality.

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“…D-mannose not only downregulates gut dysbiosis by enhancing intestinal barrier integrity [114,115] but also suppresses the adipokine and cytokine triad (TNF-α, IL-6, IL-1β) [120][121][122], linked to cancer [123,124], cardiovascular disease [125], stroke [126], obesity [127], diabetes [128], neurodegenerative disease [129], and autoimmune disease [130,131]. D-mannose suppresses these autoimmune diseases like T1DM, asthma, and SLE [132] by suppressing IFN-γ [39,115]. D-mannose can suppress ERK (extracellular signal regulated kinase) signaling pathways (see Figure 3) [133] integral to TGF-β induced organ fibrosis [134], transformation of fibroblasts into CAFs [135], epithelial/endothelial mesenchymal transformation (EMT) [136], and VEGF synthesis [137].…”

Section: B D-mannosementioning

confidence: 99%

Staunch the Age Related Decline into Depression, Dementia, Diabetes, Obesity, Cancer, Long Covid, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play

Chambers

2024

Preprint

View full text Add to dashboard Cite

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via the gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. A dysbiotic gut microbiome, low in biodiversity and butyrate producers, triggers altered tryptophan metabolism and release of proinflammatory cytokines, predominantly TNF-α, IL-6, and IL-1β, that also characterize chronic inflammation, oxidative stress, and a multitude of diseases, all exhibiting low HRV. Gut dysbiosis upregulates IFN-γ and with it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to that of kynurenine, increasing the kynurenine to tryptophan ratio (KTR). An elevated KTR is positively linked to neurodegenerative and autoimmune diseases and negatively linked to HRV. Elevated IDO activity is not only enzymatic but also an intracellular signal transducer potentiated by TGF-β. This cytokine is the primary determinant of the TME. The triple play of a prebiotic (d-mannose), probiotic (bifidobacteria and lactobacilli), and postbiotic (butyrate) might improve intestinal barrier integrity, suppress the inflammatory cytokine triad, balance IFN-γ and TGF-β, depress KTR, elevate HRV, and extend lifespan.

show abstract

Mannose: a potential saccharide candidate in disease management

Cited by 29 publications

References 176 publications

Production of Mannooligosaccharides from Açaí Seed by Immobilized β-Mannanase

Production of Mannooligosaccharides from Açaí Seed by Immobilized β-Mannanase

Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (POTS), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play

Staunch the Age Related Decline into Depression, Dementia, Diabetes, Obesity, Cancer, Long Covid, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play

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