DOK7 CpG hypermethylation in blood leukocytes as an epigenetic biomarker for acquired tamoxifen resistant in breast cancer

Identification of exosome-related gene signature as a promising diagnostic and therapeutic tool for breast cancer

“…High DOK7 expression has been associated with favorable prognosis in acute myeloid leukemia [ 79 ]. Conversely, reduced DOK7 expression has been linked to poor survival in lung cancer [ 80 ] and the acquisition of tamoxifen resistance in breast cancer [ 81 ]. The DOK7 gene encodes the kinase binding protein Dok-7, which is critical for the development and function maintenance of the neuromuscular junction [ 82 ].…”

Oestrogen receptor positive breast cancer and its embedded mechanism: breast cancer resistance to conventional drugs and related therapies, a review

“…The structural functional changes in these proteins arise owing to mutational or epigenetic variations in the gene. It may also occur owing to variations in miRNA levels within the cells; figure 3 illustrates five major mechanisms of such alterations and variations, including overexpression of drug efflux transporters, alteration of enzymes involved in drug metabolism, drug target mutations, miRNA expressional alterations and epigenetic alterations [61][62][63][64][65][66][67][68][69].…”

“…DOK7 hypermethylation is detected in BC cells resistant to tamoxifen [ 68 , 113 ]. DOK7 functions as a substrate that eventually participates in tyrosine kinase activation.…”