1984
DOI: 10.1523/jneurosci.04-07-01800.1984
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Routing of transmitter and other changes in fast axonal transport after transection of one branch of the bifurcate axon of an identified neuron

Abstract: The regulation of the quantities and types of organelles that leave the neuronal cell body destined for use in the axon and its terminals is not well understood. We had previously found that transport of transmitter undergoes a precise down regulation when most of one branch of the bifurcate axon of an identified serotonergic neuron was removed. We have now investigated further the nature of the regulatory event and the reason for its initiation by eliminating portions of the axonal tree of this neuron. We fin… Show more

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Cited by 10 publications
(7 citation statements)
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“…We studied the partitioning of the glycoproteins 2 wk after the CBC had been transected distally. At this time, 70% of the serotonin, rather than the normal 36%, is transported in the PLN (Aletta and Goldberg, 1984). Were there selectivity in the partitioning of transported material, we would expect to have observed consistent differences in the gel profiles of the CBC and PLN, that is, either a consistent enrichment of the 75 kDa glycoprotein relative to the other glycoproteins in the PLN or a consistent enrichment of another of the glycoproteins in the CBC.…”
Section: Resultsmentioning
confidence: 82%
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“…We studied the partitioning of the glycoproteins 2 wk after the CBC had been transected distally. At this time, 70% of the serotonin, rather than the normal 36%, is transported in the PLN (Aletta and Goldberg, 1984). Were there selectivity in the partitioning of transported material, we would expect to have observed consistent differences in the gel profiles of the CBC and PLN, that is, either a consistent enrichment of the 75 kDa glycoprotein relative to the other glycoproteins in the PLN or a consistent enrichment of another of the glycoproteins in the CBC.…”
Section: Resultsmentioning
confidence: 82%
“…Within hours after transection of the CBC relatively far from the cerebral ganglion, the majority of the serotonergic vesicles that would ordinarily be transported by that branch instead enter the PLN branch, despite the continued ability of the transected branch to transport its normal complement of vesicles (Aletta and Goldberg, 1984). Thus, the partitioning of vesicles is strongly influenced in this situation by the states of the endings of the branches.…”
Section: Resultsmentioning
confidence: 99%
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