Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs

Bosselmann, Stephanie; Williams, Robert O.

doi:10.1007/978-1-4614-1144-4_1

Cited by 11 publications

(10 citation statements)

References 80 publications

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“…It is estimated that 40 % of the approved drugs and almost 90% of drugs candidates are poorly soluble (Kalepu and Nekkanti 2015). For this reason, the development of new strategies to enhance drug solubility remains one of the major research areas in drug discovery and development process (Bellantone 2014, Bosselmann andWilliams 2012). An approach to enhance the solubility of ionisable drugs is by adjusting the pH of the solvent or by forming soluble salts (Kalepu and Nekkanti 2015, Owen 2013, Serajuddin 2007.…”

Section: Introductionmentioning

confidence: 99%

The use of albumin solid dispersion to enhance the solubility of unionizable drugs

Khoder

Abdelkader

ElShaer

et al. 2017

Pharmaceutical Development and Technology

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In this study, solid dispersions of prednisolone (PRD) and bovine serum albumin (BSA) were prepared by spray drying and freeze drying methods using a PRD:BSA solution [20:1 molar ratio (MR)]. PRD-BSA dispersed mixtures were characterized by scanning electron microscopy (SEM), and powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC). PRD-BSA physical and dispersed mixtures showed significantly higher solubility in water than that of unprocessed drug. Enhancement factor of six was obtained in both physical mixture and solid dispersion solubility studies. In-vitro dissolution and release studies under physiological conditions showed an immediate release of PRD from the solid dispersions, with almost 90% of the drug dissolved in the first 10 min. PRD was immediately released from BSA binding complex. This study demonstrates the potential for the use of BSA to enhance the solubility and dissolution rate, hence bioavailability, of the unionizable drugs.

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Section: Introductionmentioning

confidence: 99%

The use of albumin solid dispersion to enhance the solubility of unionizable drugs

Khoder

Abdelkader

ElShaer

et al. 2017

Pharmaceutical Development and Technology

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“…According to Nernst-Brunner/Noyes-Whitney equation, low solubility implies slow dissolution rate, hence, compromising further drug bioavailability. Almost 60-70% of drugs in development are poorly soluble in water with almost 40% being practically insoluble (Bosselmann and Williams, 2012). Over the years, different strategies have been developed to overcome poor solubility issues.…”

Section: Introductionmentioning

confidence: 99%

Efficient approach to enhance drug solubility by particle engineering of bovine serum albumin

Khoder

Abdelkader

ElShaer

et al. 2016

International Journal of Pharmaceutics

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Please cite this article as: Khoder, Mouhamad, Abdelkader, Hamdy, ElShaer, Amr, Karam, Ayman, Najlah, Mohammad, Alany, Raid G., Efficient approach to enhance drug solubility by particle engineering of bovine serum albumin.International Journal of Pharmaceutics http://dx.doi.org/10. 1016/j.ijpharm.2016.11.019 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…The Noyes and Whitney equation showed, when the particles size reduces, the surface area of the particles, solubility and dissolution rate of drug will increase 22,23 .…”

Section: Drug Saturationsolubilitymentioning

confidence: 99%

Nanosuspensions as a promising approach to enhance bioavailability of poorly soluble drugs : An update

Azimullah¹,

Sudhakar²,

Kumar³

et al. 2019

J. Drug Delivery Ther.

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Solubility is a vital factor for devloping drug delivery systems for poorly water soluble drugs. Several conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly water soluble. Nanosuspension technology can be used to enhance the solubilty, stability as well as the bioavailability of poorly water soluble drugs. Nanosuspensions are biphasic systems comperising of pure drug particles dispersed in an aqueous vehicle, stabilized by surfac active agents. Fabrication of nanosuspension is simple and more advantageous than other approaches. Techniques like high-pressure homogenization, wet milling, emulsification, solvent evaporation, bottom up technology and top down technology have been applicable in the fabrication of nanosuspensions. Nanosuspension delivery is possible by several routes, such as oral, pulmonary, parenteral and ocular routes. Nanosuspension not only solves solubility and bioavailability issue, but improve drug safety and efficacy. In this context, we reviewed the current techniques used to develop nanosuspensions and their recents studies application in drug delivery system. Keywords : Solubility, fabrication, Characterization, Applications, Nanosuspension.

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Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs

Cited by 11 publications

References 80 publications

The use of albumin solid dispersion to enhance the solubility of unionizable drugs

The use of albumin solid dispersion to enhance the solubility of unionizable drugs

Efficient approach to enhance drug solubility by particle engineering of bovine serum albumin

Nanosuspensions as a promising approach to enhance bioavailability of poorly soluble drugs : An update

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