Nanosuspensions as a promising approach to enhance bioavailability of poorly soluble drugs : An update

Abstract

Solubility is a vital factor for devloping drug delivery systems for poorly water soluble drugs. Several conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly water soluble. Nanosuspension technology can be used to enhance the solubilty, stability as well as the bioavailability of poorly water soluble drugs. Nanosuspensions are biphasic systems comperising of pure drug particles dispersed in an aqueous vehicle, stabilized by surfac active agents. Fabrication of nanosuspension is simple and more advantageous than other approaches. Techniques like high-pressure homogenization, wet milling, emulsification, solvent evaporation, bottom up technology and top down technology have been applicable in the fabrication of nanosuspensions. Nanosuspension delivery is possible by several routes, such as oral, pulmonary, parenteral and ocular routes. Nanosuspension not only solves solubility and bioavailability issue, but improve drug safety and efficacy. In this context, we reviewed the current techniques used to develop nanosuspensions and their recents studies application in drug delivery system.
 Keywords : Solubility, fabrication, Characterization, Applications, Nanosuspension.

Development of Nanosuspension Formulations Compatible with Inkjet Printing for the Convenient and Precise Dispensing of Poorly Soluble Drugs

“…However, nanosuspensions have emerged as one enabling formulation approach for the formulation of poorly soluble drug candidates [29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44]. Nanosuspensions are colloidal suspensions of drug nanocrystals with sizes generally between 100-400 nm in diameter.…”

Kajian Pengembangan Sediaan Nanosuspensi Untuk Penghantaran Intravena Obat Sukar Larut Air

“…Nanosuspensi adalah salah satu bentuk sediaan berbasis nanoteknologi (5). Nanosuspensi merupakan sistem dispersi koloidal mengandung partikel obat dengan ukuran <1µm yang distabilkan oleh surfaktan dan atau polimer (6). Surfaktan dan polimer bekerja mencegah terjadinya kembali aglomerasi partikel dengan mekanisme stabilisasi sterik, elektrostatik, atau elektrosterik (7).…”

“…2-methoxyestradiol menggunakan poloxamer 188 sebagai penstabil utama, dengan penambahan CMC-Na dan natrium lauril sulfat (22). Poloxamer-188 adalah polimer sintetik yang aman untuk digunakan baik secara oral, parenteral, ataupun topikal karena masuk kategori GRAS (generally regarded as safe) menurut FDA (6,25). Poloxamer-188 berperan sebagai polimer sekaligus surfaktan untuk menstabilkan sistem nanosuspensi dengan prinsip stabilisasi sterik (ruang) (42).…”

“…Kombinasi bahan penstabil umum dilakukan untuk meningkatkan efek stabilisasi yang terjadi. Lesitin adalah amino acid-based stabilizer diketahui memberikan efek stabilisasi permukaan (6). Lesitin atau fosfatidilkolin akan membentuk lapisan pelindung pada permukaan nanopartikel dan akan memberikan efek penghalang sterik sehingga akan mencegah terjadinya agregasi dan dapat meningkatkan stabilitasnya (44).…”

Development, characterisation and evaluation of pvp k-30/peg solid dispersion containing ketoprofen

“…Therefore, the development of new techniques to enhance drug solubility remains one of the major research areas in drug discovery and development process 2 . A scan of literature has revealed that numerous attempts has been made to improve the solubility and dissolution of drugs that include cyclodextrins complexes 3 , drug micronization in to amorphous form 4 , prodrug formation 5 , solid dispersion 6,-12 , salt formation 13 , solubilization of drug in solvents, nanoparticles technology 14 , physical modification, nanosuspension [15][16][17][18][19] , modification of crystal habit such as polymorphus, pseudo polymorphous, self-emulsifying drug delivery systems ( SEDDS) 20 , liposomes [21][22][23][24][25] and use of surfactant " micelization" 26 etc. Out of numerous techniques explored so far solid dispersion have been proved to be the most promising strategy to improve the solubility of poorly watersoluble drugs.…”