Rotavirus infection and bradycardia-apnoea-episodes in the neonate

Riedel, Frank; Kroener, Thomas; Stein, Karin; Nuesslein, Thomas G.; Rieger, Christian

doi:10.1007/bf02309854

Cited by 9 publications

(3 citation statements)

References 22 publications

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“…30 A retrospective study showed that rotavirus infection in neonates, particularly full-term infants, was associated with a high incidence of bradycardia-apnea episodes, suggesting central nervous system involvement. 31 That study also reported development of seizures in 8 of 114 neonates with rotavirus-positive stools.…”

Section: Discussionmentioning

confidence: 85%

Association of Rotavirus With Seizures Accompanied by Cerebral White Matter Injury in Neonates

Moon

Lee

2015

J Child Neurol

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We aimed to identify whether rotavirus, human parechovirus, or enterovirus are causative or associated viral pathogens of seizures accompanied by diffuse cerebral white matter injury in neonates. Thirty neonates who presented with seizures and diffusion-restriction in the widespread bilateral cerebral white matter on diffusion-weighted magnetic resonance imaging (MRI) were included in this study. All patients were tested for rotavirus, human parechovirus, and enterovirus by using reverse transcription PCR. Stool, cerebrospinal fluid, and serum samples were examined in 30, 25, and 20 patients, respectively. Rotavirus was detected in stool samples from all 30 patients (100%). Stool samples from 5 patients (16.7%) were also positive for enterovirus. Rotavirus or human parechovirus were not detected in any cerebrospinal fluid samples from 25 patients, but 1 patient tested positive for enterovirus. No virus was detected in any of 20 patient sera. This study indicated an association between rotavirus and seizures accompanied by diffuse cerebral white matter lesions in neonates.

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Section: Discussionmentioning

confidence: 85%

Association of Rotavirus With Seizures Accompanied by Cerebral White Matter Injury in Neonates

Moon

Lee

2015

J Child Neurol

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“…A significantly higher incidence of bradycardia-apnoea episodes (BAE) has been noticed two days before and two days a er the diagnosis of rotavirus infection in infants. These episodes were followed by cyanosis and required intervention more o en than did BAE episodes in rotavirus negative infants (Riedel 1996). Rotavirus infected neonates stay in the hospital longer than non-infected neonates, causing increased stress to the family and increased cost to the neonatal unit (Strodtbeck 1986).…”

Section: Description Of the Conditionmentioning

confidence: 99%

Oral immunoglobulin for the treatment of rotavirus diarrhea in low birth weight infants

Pammi

Haque

2011

Cochrane Database of Systematic Reviews

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“…Adenovirus has been associated with symptoms of systemic infection and rotavirus with apnoeic-bradycardic spells, diarrhoea and necrotizing enterocolitis (NEC) in newborn infants (1)(2)(3). Yet, the presence of virus in the stools seems mostly to be either asymptomatic or associated with mild symptoms (4).…”

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confidence: 99%

Screening of rotavirus and adenovirus infections during prolonged hospitalization in a neonatal unit

et al. 2001

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Hällströ m M, Vesikari T, Janas M, Ikonen S, Tammela O. Screening of rotavirus and adenovirus infections during prolonged hospitalization in a neonatal unit. Acta Paediatr 2001; 90: 1196-1198 Rotavirus and adenovirus infections in 308 infants hospitalized for longer than 1 wk, and cases with necrotizing enterocolitis, were screened in a neonatal unit during a 15 mo period, covering two rotavirus epidemics in the community. Altogether, 1020 stool samples were collected weekly until hospital discharge, and in necrotizing enterocolitis cases at the onset of symptoms, and tested for rotavirus and adenovirus by means of enzyme-linked immunosorbent assay. The positive samples were further analysed by polymerase chain reaction. Enzyme-linked immunosorbent assay revealed ve adenovirus-positive cases, which were tested negative by polymerase chain reaction. Out of 16 necrotizing enterocolitis cases, one was adenovirus-and another rotavirus positive when tested by polymerase chain reaction, the latter having a concomitant Candida albicans septicaemia.Conclusion: Routine rotavirus and adenovirus screening in hospitalized neonates seems to be unnecessary. Viral diagnostic examinations should be considered in patients with necrotizing enterocolitis.

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Rotavirus infection and bradycardia-apnoea-episodes in the neonate

Cited by 9 publications

References 22 publications

Association of Rotavirus With Seizures Accompanied by Cerebral White Matter Injury in Neonates

Association of Rotavirus With Seizures Accompanied by Cerebral White Matter Injury in Neonates

Oral immunoglobulin for the treatment of rotavirus diarrhea in low birth weight infants

Screening of rotavirus and adenovirus infections during prolonged hospitalization in a neonatal unit

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