Rotating magnetic particles for lab-on-chip applications – a comprehensive review

Moerland, Christian P.; IJzendoorn, L.J. van; Prins, Mwj Menno

doi:10.1039/c8lc01323c

Cited by 50 publications

(38 citation statements)

References 132 publications

(189 reference statements)

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“…In the context of molecular diagnosis, magnetic particles have been applied for mixing fluids, selectively capturing, concentrating, transferring, and labelling targeted analytes, performing stringency and washing steps, and probing biophysical properties of analytes [37,38,39,46,47,48]. In this tasks, magnetic separation offers a variety of advantages, including high-throughput, low costs, energy consumption efficiency, increased specificity, stability, and sensitivity [27,31,49], and it has been intensively used, since most biological materials are not susceptible to magnetic fields and the magnetic particles can be easily separated from the reaction mixture and re-dispersed after the removal of the magnetic field [30].…”

Section: Magnetic Particles In Diagnosismentioning

confidence: 99%

Magnetic Particles for Advanced Molecular Diagnosis

2019

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Molecular diagnosis is the field that aims to develop nucleic-acid-based analytical methods for biological markers and gene expression assessments by combining laboratory medicine and molecular genetics. As it gradually becomes a clinical reality, molecular diagnosis could benefit from improvements resulting from thorough studies that could enhance the accuracy of these methods. The application of magnetic particles in molecular diagnosis tools has led to tremendous breakthroughs in terms of specificity, sensitivity, and discrimination in bioassays. Therefore, the aim of this review is to highlight the principles involved in the implementation of magnetic particles for sample preparation and targeted analyte isolation, purification, and extraction. Furthermore, the most recent advancements in the area of cancer and infectious disease diagnosis are presented, with an emphasis on screening and early stage detection.

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Section: Magnetic Particles In Diagnosismentioning

confidence: 99%

Magnetic Particles for Advanced Molecular Diagnosis

2019

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“…We fabricated nanopockets with a three-layer stack of 15 nm Au, 10 nm NiFe, and 10 nm TiOx to show the versatility of the fabrication method, leading to multifunctional nanopocket structures. While gold is commonly employed for optical reasons [40,41], NiFe serves as a magnetic layer to realize magnetic nanoparticles [4,14], and the TiOx can be used as a dielectric layer which can, for example, be interesting for energy conversion and photochemistry applications [42,43]. In the chosen multilayer structure, the TiOx also electrically insulates the magnetic from the gold layer.…”

Section: Polarization Parallel To Long Particle Ellipse Axis Polarizamentioning

confidence: 99%

“…Nanostructured surfaces and nanoparticles are widely employed in many fields of research and technology, and there is an ever-growing demand for reliable and reproducible nanofabrication methods. In biology and medicine, nanostructured surfaces and nanoparticles are employed both because of their optical [1,2] or magnetic [3,4] properties alone as well as due to a combination of their optical and magnetic properties [5][6][7][8][9]. Nanostructured surfaces and nanoparticles are also employed in electronics, photovoltaics and sensing applications due to their specific physical properties [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Nanostructures and Nanopocket Particles Fabricated by Nanoimprint Lithography

et al. 2019

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Nanostructured surfaces and nanoparticles are already widely employed in many different fields of research, and there is an ever-growing demand for reliable, reproducible and scalable nanofabrication methods. This is especially valid for multifunctional nanomaterials with physical properties that are tailored for specific applications. Here, we report on the fabrication of two types of nanomaterials. Specifically, we present surfaces comprising a highly uniform array of elliptical pillars as well as nanoparticles with the shape of nanopockets, possessing nano-cavities. The structures are fabricated by nanoimprint lithography, physical and wet-chemical etching and sputter deposition of thin films of various materials to achieve a multifunctional nanomaterial with defined optical and magnetic properties. We show that the nanopockets can be transferred to solution, yielding a nanoparticle dispersion. All fabrication steps are carefully characterized by microscopic and optical methods. Additionally, we show optical simulation results that are in good agreement with the experimentally obtained data. Thus, this versatile method allows to fabricate nanomaterials with specific tailor-made physical properties that can be designed by modelling prior to the actual fabrication process. Finally, we discuss possible application areas of these nanomaterials, which range from biology and medicine to electronics, photovoltaics and photocatalysis.

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“…Most biological or chemical samples are composed of a mixture of several kinds of reagents, and thus on-chip mixing is an essential step in many applications [2]. With the help of external resources, such as electric signals [3], magnetic fields [4], acoustic energy [5], or light sources [6], microfluids can be mixed efficiently. In fact, the ability to generate stable linear [7] or nonlinear spatial chemical gradient profiles within microfluidics has been adapted extensively for analysis [8].…”

Section: Introductionmentioning

confidence: 99%

A Microfluidic Concentration Gradient Maker with Tunable Concentration Profiles by Changing Feed Flow Rate Ratios

Zhang

Meng

et al. 2020

Micromachines

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Microfluidic chips—in which chemical or biological fluid samples are mixed into linear or nonlinear concentration distribution profiles—have generated enormous enthusiasm of their ability to develop patterns for drug release and their potential toxicology applications. These microfluidic devices have untapped potential for varying concentration patterns by the use of one single device or by easy-to-operate procedures. To address this challenge, we developed a soft-lithography-fabricated microfluidic platform that enabled one single device to be used as a concentration maker, which could generate linear, bell-type, or even S-type concentration profiles by tuning the feed flow rate ratios of each independent inlet. Here, we present an FFRR (feed flow rate ratio) adjustment approach to generate tens of types of concentration gradient profiles with one single device. To demonstrate the advantages of this approach, we used a Christmas-tree-like microfluidic chip as the demo. Its performance was analyzed using numerical simulation models and experimental investigations, and it showed an excellent time response (~10 s). With on-demand flow rate ratios, the FFRR microfluidic device could be used for many lab-on-a-chip applications where flexible concentration profiles are required for analysis.

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Rotating magnetic particles for lab-on-chip applications – a comprehensive review

Cited by 50 publications

References 132 publications

Magnetic Particles for Advanced Molecular Diagnosis

Magnetic Particles for Advanced Molecular Diagnosis

Multifunctional Nanostructures and Nanopocket Particles Fabricated by Nanoimprint Lithography

A Microfluidic Concentration Gradient Maker with Tunable Concentration Profiles by Changing Feed Flow Rate Ratios

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