Rosinidin Protects against Cisplatin-Induced Nephrotoxicity via Subsiding Proinflammatory and Oxidative Stress Biomarkers in Rats

Abstract

Background: Rosinidin is a flavonoid anthocyanin pigmentation found in shrub flowers such as Catharanthus roseus and Primula rosea. The molecular docking studies predicted that rosinidin has adequate structural competency, making it a viable medicinal candidate for the treatment of a wide range of disorders. The current study intends to assess rosinidin nephroprotective efficacy against nephrotoxicity induced by cisplatin in rats. Materials and Methods: Oral acute toxicity tests of rosinidin were conducted to assess potential toxicity in animals, and it was shown to be safe. The nephroprotective effect of rosinidin 10, and 20 mg/kg were tested in rats for 25 days with concurrent administration of cisplatin. Several biochemical parameters were measured to support enzymatic and non-enzymatic oxidative stress such as superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GSH). Likewise, changes in several non-protein-nitrogenous components and blood chemistry parameters were made to support the theory linked with the pathogenesis of chemical-induced nephrotoxicity. Results: Cisplatin caused significant changes in biochemical, enzymatic, and blood chemistry, which rosinidin efficiently controlled. Conclusions: The present investigation linked rosinidin with nephroprotective efficacy in experimental models.

Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways

“…The rats were also examined for any clinical signs, including changes in behaviour and body weight [ 18 ]. Europinidin was given orally in rats as per the previously published toxicity studies [ 19 , 20 , 21 ].…”

Effects of the Anthocyanin Hirsutidin on Gastric Ulcers: Improved Healing through Antioxidant Mechanisms

“…Hirsutidin was tested for acute oral toxicity (LD 50 ) using the Organisation for Economic Co-operation and Development’s ANNEX-423 criteria. It was diluted in a solution of sodium carboxymethyl cellulose (SCMC, 0.5% w/v) and given to mice orally. , …”

“…It was diluted in a solution of sodium carboxymethyl cellulose (SCMC, 0.5% w/v) and given to mice orally. 25,26 Experiment. Wistar rats (n = 24) were divided into four groups at random: normal saline-treated (normal control), ethanol-treated (ethanol control), 10 mg/kg hirsutidin + ethanol-treated (hirsutidin 10), and 20 mg/kg hirsutidin + ethanol-treated (hirsutidin 20).…”

Hirsutidin Prevents Cisplatin-Evoked Renal Toxicity by Reducing Oxidative Stress/Inflammation and Restoring the Endogenous Enzymatic and Non-Enzymatic Level

“…The primary clinical characteristics of chronic kidney disease (CKD) are the sequential loss of vital functionalities, which, finally, results in chronic renal failure and requirement of kidney dialysis or transplants to preserve quality of life [ 6 ]. Acute kidney disease (AKD) is linked to a high prevalence of CKD, and people whose CKD is made worse by AKD have a higher death risk, according to earlier research [ 7 ]. A previous study indicates that a significant factor in about 60% of AKD cases in healthcare settings is drug-induced nephrotoxicity [ 8 ].…”

“…Numerous factors, including oxidative stress, inflammation, apoptosis, and dysfunctionality of mitochondria are symptomatic of cisplatin-induced nephropathy. However, the exact cause of the dysfunction is not fully understood [ 7 ].…”