Effects of the Anthocyanin Hirsutidin on Gastric Ulcers: Improved Healing through Antioxidant Mechanisms

Abstract

The goal of this study was to determine the effect of hirsutidin on ethanol-induced stomach ulcers in rats. Rats (n = 24 rats/group) were separated at random into the following groups: normal saline-treated (normal control), ethanol-treated (ethanol control), 10 mg/kg hirsutidin + ethanol-treated (hirsutidin 10), and 20 mg/kg hirsutidin + ethanol-treated (hirsutidin 20). All the groups received the respective treatment orally for 7 days. On day 7, i.e., after 24 h of fasting, except for the normal control group, all the groups orally received 5 mL/kg of ethanol. Four hours later, rats were anaesthetized, serum was isolated from the blood, and biochemical tests were performed. The stomach tissue was utilized for ulcer grading, histology, and biochemical analysis. The rats developed stomach acidity and ulcers after being given ethanol based on increased ulcer score, disturbed cellular architecture, increased oxidative stress, myeloperoxidase and decreased endogenous antioxidants, and nitric oxide and prostaglandin E2 concentration. Ethanol-treated rats also displayed increased tumor necrosis factor-α, aspartate aminotransferase, alanine transaminase, alkaline phosphatase, and inflammatory cytokines. The treatment with hirsutidin protected and significantly restored all serum parameters in ethanol-induced stomach ulcers and may have antiulcer activity.

Efficacy and safety of Piwei Peiyuan Prescription in the treatment of chronic atrophic gastritis: A multicenter, double-blind, double-simulated, randomized, controlled clinical trial

“…[ 10 ] An animal study reported that anthocyanin polyphyllin mitigated gastric ulcers and elevated the concentration of PGE2 in serum. [ 48 ] The expression of these 3 indicators was statistically markedly increased in both groups after treatment. Considering the mechanism of these 3 indicators, it can be concluded that Piwei Peiyuan Prescription improves symptoms and boosts gastrointestinal motility and mucosal repair.…”

Albizzia chinensis (Osbeck) Merr extract YS ameliorates ethanol‐induced acute gastric ulcer injury in rats by regulating NRF2 signaling pathway

“…5,[9][10][11] Oxidative stress is implicated in gastrointestinal mucosal injury. 12,13 Controlling oxidative stress is essential for the treatment of this pathology. NRF2 is a crucial regulator of antioxidant factors and activation of NRF2 results in anti-ulcer effects.…”

Protective Effect of Hirsutidin against Rotenone-Induced Parkinsonism via Inhibition of Caspase-3/Interleukins-6 and 1β

“…Another study showed the hepatoprotective properties of hirsutidin by attenuating alcohol-induced oxidative stress in rodents and the antiulcer consequence of hirsutidin against ethanol-induced ulcers in rats via regulation of antioxidant mechanisms . There is no clear mechanistic role of hirsutidin but due to its strong antioxidant property, it may be essentially used in treating the disorders.…”

“…17 It is believed that this skill serves as a protection against variability of illnesses brought on by ROS. 17 According to studies, dietary foods high in anthocyanins have positive impacts on several health issues, including cardiovascular health, 18,19 diabetes, 20 obesity, 20,21 bacterial infection, 22 cancer, 23 eye health, 24 and neurotoxicity. 25 A member of the chemical family known as anthocyanins, hirsutidin is an O-methylated anthocyanidin.…”

“…Another study showed the hepatoprotective properties of hirsutidin by attenuating alcohol-induced oxidative stress in rodents 26 and the antiulcer consequence of hirsutidin against ethanol-induced ulcers in rats via regulation of antioxidant mechanisms. 20 There is no clear mechanistic role of hirsutidin but due to its strong antioxidant property, it may be essentially used in treating the disorders. Current orthodox treatments for PD are inadequate, presenting some demerits, hence it is necessary to identify potential components from the natural origin for the treatment of neurodegenerative diseases, such as PD.…”