Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways

Altharawi, Ali; Alharthy, Khalid M.; Althurwi, Hassan N.; Albaqami, Faisal F.; Alzarea, Sami I.; Al‐Abbasi, Fahad A.; Nadeem, Muhammad Shahid; Kazmi, Imran

doi:10.3390/molecules27217159

Cited by 10 publications

(10 citation statements)

References 58 publications

(54 reference statements)

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“…15 The flavonoid europinidin, which is generated from the metal europium, has been demonstrated to have positive effects on liver health. 16,17 Previously, europinidin published rotenone-activated Parkinson's disease by inhibited inflammation and lipid peroxidation, 18 effectiveness in preventing streptozotocin-induced memory impairment, 19 and ulcer protective activity in rats. 20 The cause of the current appraisal was to analyze the consequences of europinidin on EtOH-induced liver damage in rats.…”

Section: Introductionmentioning

confidence: 99%

“…Europinidin is a compound, found in the plants Plumbago Europea and Ceratostigma plumbaginoides, that belongs to the Plumbaginaceae family, and it is an o-methylated derivative of delphinidin. , Potent anti-inflammatory and antioxidant effects have been demonstrated in Europium, a naturally occurring metal . The flavonoid europinidin, which is generated from the metal europium, has been demonstrated to have positive effects on liver health. , …”

Section: Introductionmentioning

confidence: 99%

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Effect of Europinidin against Alcohol-Induced Liver Damage in Rats by Inhibiting the TNF-α/TGF-β/IFN-γ/NF-kB/Caspase-3 Signaling Pathway

et al. 2023

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Background: The effect of europinidin on alcoholic liver damage in rats was examined in this research. Methods: A total of 24 Wistar rats were grouped in the same way into four groups: normal control (normal), ethanol control (EtOH), europinidin low dose (10 mg/kg), and europinidin higher dose (20 mg/kg). The test group rats were orally treated with europinidin-10 and europinidin-20 for 4 weeks, whereas 5 mL/kg distilled water was administered to control rats. In addition, 1 h after the last dose of the above-mentioned oral treatment, 5 mL/kg (i.p.) EtOH was injected to induce liver injury. After 5 h of EtOH treatment, samples of blood were withdrawn for biochemical estimations. Results: Administration of europinidin at both doses restored all of the estimated serum, i.e., liver function tests (ALT, AST, ALP), biochemical test (Creatinine, albumin, BUN, direct bilirubin, and LDH), lipid assessment (TC and TG), endogenous antioxidants (GSH-Px, SOD, and CAT), malondialdehyde (MDA), nitric oxide (NO), cytokines (TGF-β, TNF-α, IL-1β, IL-6, IFN-γ, and IL-12), caspase-3, and nuclear factor kappa B (NF-κB) associated with the EtOH group. Conclusion: The results of the investigation showed that europinidin had favorable effects in rats given EtOH and may have hepatoprotective potential property.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Europinidin against Alcohol-Induced Liver Damage in Rats by Inhibiting the TNF-α/TGF-β/IFN-γ/NF-kB/Caspase-3 Signaling Pathway

et al. 2023

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“…To assess the passing of time and compare each rat’s performance, the sessions were videotaped. Each rat had a predetermined cutoff time of 3 min. − …”

Section: Methodsmentioning

confidence: 99%

“…The rat was allowed to measure a distance, no rearing was done, time was recorded by starting location, and the numeral of admissions was counted in the center square. Total movement was calculated …”

Section: Methodsmentioning

confidence: 99%

Protective Effect of Hirsutidin against Rotenone-Induced Parkinsonism via Inhibition of Caspase-3/Interleukins-6 and 1β

et al. 2023

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A participant of the chemical family recognized as anthocyanins, hirsutidin is an O-methylated anthocyanidin. It is a natural substance, i.e., existing in Catharanthus roseus (Madagascar periwinkle), the predominant component in petals, as well as callus cultures. The literature review indicated a lack of scientifically verified findings on hirsutidin's biological activities, particularly its anti-Parkinson's capabilities. Using the information from the previous section as a reference, a present study has been assessed to evaluate the anti-Parkinson properties of hirsutidin against rotenone-activated Parkinson's in experimental animals. For 28 days, rats received hirsutidin at a dose of 10 mg/kg and rotenone at a dose of 0.5 mg/kg s.c. to test the neuroprotective effects. The hirsutidin was given 1 h before the rotenone. Behavioral tests, including the rotarod test, catalepsy, Kondziela's inverted screen activity, and open-field analysis, were performed. The levels of neurotransmitters (5-HT, DOPAC, 5-HIAA, dopamine, and HVA), neuroinflammatory markers (TNF-α, IL-6, IL-1β, caspase-3), an endogenous antioxidant, nitrite content, and acetylcholine were measured in all the rats on the 29th day. Hirsutidin exhibited substantial behavioral improvement in the rotarod test, catalepsy, Kondziela's inverted screen activity, and open-field test. Furthermore, hirsutidin restored neuroinflammatory markers, cholinergic function, nitrite content, neurotransmitters, and endogenous antioxidant levels. According to the study, hirsutidin has anti-inflammatory and antioxidant characteristics. As a result, it implies that hirsutidin may have anti-Parkinsonian effects in rats.

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“…Lipid peroxidation seriously damages lipoproteins and the membranes of cells and organelles. Acroléin, isoprostanes, 4hydroxynonenal (HNE), malondialdehyde (MDA), and conjugated dienes are byproducts of this process that harm neuronal cells [14]. As oxidative stress advances, it causes chromatin condensation, DNA breakage, and the activation of cysteine-proteases and caspases.…”

Section: Introductionmentioning

confidence: 99%

Spatial memory impairment is associated with oxidative stress, neurodegeneration and abnormalities neuromorphology in the hippocampus of rotenone-induced Parkinson’s mouse model: neuroprotective role of a specialized Bacopa monnieri extract (CDRI-08)

Gupta,

Prasad

2024

Preprint

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Parkinson's disease (PD), a neurodegenerative disorder linked with ageing, is associated with both motor and non-motor problems. Memory loss is a common non-motor symptom of PD, particularly as the disease progresses, and it can lead to cognitive impairment.The objective of this study was to investigate the underlying biochemical, molecular, and neuroanatomical pathways that contribute to learning and memory impairment in PD. The study investigates the potential neuroprotective and neurotherapeutic effects of the Bacopa monnieriextract (CDRI-08), a natural nootropic medication, on memory deterioration associated with PD. To comprehend the information provided, we developed a PD mouse model by administering rotenone subcutaneously at a dose of 2mg/kg BW. Spatial working memory and the expression of α-Synuclein in the hippocampus was examined. Additionally, evaluation of the oxidative stress parameters, neuronal cell density, apoptosis in subregions of the hippocampus, and dendritic arborization and dendritic spine density in CA1 pyramidal neurons of the hippocampus. Results showed that PD exhibited a decline in their ability to remember spatial information, which can be correlated with high oxidative stress characterized by increased reactive oxygen species and lipid peroxidation levels whereas decreased activity of SOD and catalase. This oxidative stress resulted in a drop in the density of neurons due to increased cell death characterized by increased caspase-3 expression and TUNEL-positive cells, leading to a loss of dendritic length, branching, and dendritic spine density. Administering BME (CDRI-08) orally effectively alleviates the illness and additionally improves neuroprotection by strengthening and nourishing neurons by increasing the activity of antioxidant enzymes and decreasing the expression of pro-apoptotic factor caspase-3. Collectively, these findings indicate that Bacopa monnieri extract can be utilized as a herbal remedy to treat memory impairment induced by PD.

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Europinidin Inhibits Rotenone-Activated Parkinson’s Disease in Rodents by Decreasing Lipid Peroxidation and Inflammatory Cytokines Pathways

Cited by 10 publications

References 58 publications

Effect of Europinidin against Alcohol-Induced Liver Damage in Rats by Inhibiting the TNF-α/TGF-β/IFN-γ/NF-kB/Caspase-3 Signaling Pathway

Effect of Europinidin against Alcohol-Induced Liver Damage in Rats by Inhibiting the TNF-α/TGF-β/IFN-γ/NF-kB/Caspase-3 Signaling Pathway

Protective Effect of Hirsutidin against Rotenone-Induced Parkinsonism via Inhibition of Caspase-3/Interleukins-6 and 1β

Spatial memory impairment is associated with oxidative stress, neurodegeneration and abnormalities neuromorphology in the hippocampus of rotenone-induced Parkinson’s mouse model: neuroprotective role of a specialized Bacopa monnieri extract (CDRI-08)

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