Rosette-Forming Glioneuronal Tumor

Abstract

These are tumors of young adulthood (range, 12-59 yr) usually in or close to the fourth ventricle. Histologically, they are low-grade, although multiple foci or local extension may prevent total excision and account for some recurrences. On imaging, they are cystic, solid, or both, with minimal perilesional edema or mass effect. They are composed of neurocytic and glial elements, probably arising from a common progenitor in the subependymal plate, and need to be differentiated from a variety of glioneuronal tumors.

Rosette-Forming Glioneuronal Tumor of the Fourth Ventricle -Case Report-

“…These enlarging tumors had the typical histological features of RGNT, and low Ki-67 labeling index. 7,11,14) The histological differentiation between growing and indolent lesions is still unclear, so more investigation is necessary.…”

“…11) Only 19 further cases have been reported since the first series. 1,2,[7][8][9][10][11][12]14,15,17,18) We describe a case of RGNT and discuss the clinical features of this entity.…”

Rosette-forming glioneuronal tumour of the fourth ventricle: case report and review of the literature

“…Diplopia, ptosis [13], dysarthria [13,19], blurred vision [19], seizure [19,35], dizziness [25], vertigo [14,34], vomiting [21,34), clumsy walking [21,23] and neck pain and rigidity [2,19] are the other signs and symptoms of this tumour. Lethargy [13], somnolence, loss of conscious [35] and anisocoria [23] due to increased intracranial pressure may also be seen in these patients as in the presented case.…”

Rosette-forming glioneuronal tumor originating in the hypothalamus

“…However, several reports have shown poor prognosis accompanied by possible anaplastic features. Li et al and Pimentel et al reported cases of RGNTs with mild nuclear pleomorphism and intratumoral hemorrhage, and one of those cases showed obstructive hydrocephalus [20,37]. Microvascular proliferation was described in a case of recurrent RGNT 9 months after subtotal removal and in another such case 10 years after GTR, and also in a case of disseminated RGNT requiring chemoradiation after the surgery [19,21,28].…”