Rosette-forming glioneuronal tumour of the fourth ventricle: case report and review of the literature

Abstract

A b s t r a c t Rosette-forming glioneuronal tumour (RGNT) of the fourth ventricle is

Rosette-forming glioneuronal tumour of the fourth ventricle. Not always a foreseeable development

“…Until recently only about 47 cases were reported in the literature with only short follow-up [2, 7]. A review of the literature published by Hakan [9] in 2016 reported only four cases of recurrence. We observed a recurrence in our patient four years after total resection.…”

“…Initially it was described as dysembryoplastic neuroepithelial tumour of the cerebellum arising in relation to the wall of the fourth ventricle, typically in a midline location [6] with possible extension into surrounding structures. Cases involving other sites of the central nervous system including cerebellum, brainstem, pineal region, optic chiasm, hypothalamus, and cervical spinal cord have been reported [1, 2, 6–9]. In the latest 2016 WHO classification it is recognised as a neural and mixed neuronal glial tumour [10].…”

Uncommon low-grade brain tumors

“…These were originally described in the fourth ventricle but have been reported in the chiasm, suprasellar region, pineal gland, and spinal cord. 28 Commoner in females, mean age at diagnosis is 29 years. 28 The commonest presentation is headache followed by ataxia and nystagmus.…”

“…28 Commoner in females, mean age at diagnosis is 29 years. 28 The commonest presentation is headache followed by ataxia and nystagmus. Due to the long-standing nature of the tumor, hydrocephalus may be chronic.…”

“…In a review of 58 cases, there were 4 recurrences; time to recurrence was 10 years in 2 cases and 9 and 4 years in another 2. 28 Regular long-term follow-up is necessary. The role of adjuvant treatment is unknown.…”