Uncommon low-grade brain tumors

Ajithkumar, TV; Imbulgoda, Naduni; Rees, Elliott; Harris, Frances; Horan, Gail; Burke, Amos; Jefferies, Sarah; Price, Stephen J.; Cross, Justin; Allinson, Kieren

doi:10.1093/neuonc/noy151

Cited by 10 publications

(6 citation statements)

References 78 publications

(98 reference statements)

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“…The mechanism underlying the association between preNLR and severe peritumoral edema is complex and needs to be elucidated. Peritumoral edema has been described as a risk factor for early recurrence or progression and was the consequence of a disruption of the blood-brain barrier [ 27 , 28 ]. The reasons for preNLR value in predicting the occurrence and development of brain edema could be explained by neutrophil-induced neurotoxicity, increased capillary permeability, destruction of the BBB (Blood Brain Barrier), and cell swelling [29] , [30] , [31] .…”

Section: Discussionmentioning

confidence: 99%

Preoperative neutrophil-to-lymphocyte ratio (preNLR) for the assessment of tumor characteristics in lung adenocarcinoma patients with brain metastasis

Cui

Yang

Feng

et al. 2022

Translational Oncology

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Section: Discussionmentioning

confidence: 99%

Preoperative neutrophil-to-lymphocyte ratio (preNLR) for the assessment of tumor characteristics in lung adenocarcinoma patients with brain metastasis

Cui

Yang

Feng

et al. 2022

Translational Oncology

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“…Eosinophilic granular bodies and perivascular inflammation are often present. Typically, gangliogliomas align with a WHO grade 1 classification in the CNS [ 53 , 54 ].…”

Section: Gangliogliomamentioning

confidence: 99%

Imaging of supratentorial intraventricular masses in children: a pictorial review—part 2

Goncalves,

Mahecha-Carvajal,

Desa

et al. 2023

Neuroradiology

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Purpose This article is the second in a two-part series aimed at exploring the spectrum of supratentorial intraventricular masses in children. In particular, this part delves into masses originating from cells of the ventricular lining, those within the septum pellucidum, and brain parenchyma cells extending into the ventricles. The aim of this series is to offer a comprehensive understanding of these supratentorial intraventricular masses, encompassing their primary clinical findings and histological definitions. Methods We conducted a review and analysis of relevant epidemiological data, the current genetics/molecular classifications as per the fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (WHO CNS5), and imaging findings. Each supratentorial intraventricular mass was individually evaluated, with a detailed discussion on its clinical and histological features. Results This article covers a range of supratentorial intraventricular masses observed in children. These include colloid cysts, subependymal giant cell astrocytomas, ependymomas, gangliogliomas, myxoid glioneuronal tumors, central neurocytomas, high-grade gliomas, pilocytic astrocytomas, cavernous malformations, and other embryonal tumors. Each mass type is characterized both clinically and histologically, offering an in-depth review of their individual imaging characteristics. Conclusion The WHO CNS5 introduces notable changes, emphasizing the vital importance of molecular diagnostics in classifying pediatric central nervous system tumors. These foundational shifts have significant potential to impact management strategies and, as a result, the outcomes of intraventricular masses in children.

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“…Ganglioglioma are benign (WHO grade I) [1] and rare well-differentiated and typically slow-growing mixed glioneuronal tumors composed of dysplastic mature ganglion cells and neoplastic glial cells with the highest incidence rates being in children and young adults, but they can occur at any age and anywhere in the central nervous system [2][3][4]. They are mainly characterized by a space-occupying lesion in the temporal and frontal lobes and are usually associated with chronic drug-resistant epilepsy [3][4][5]. The standard treatment is complete surgical resection [4,6], but even then ganglioglioma can develop a malignant transformation into anaplastic ganglioglioma (AGGL) classified as a grade III tumor [1,7].…”

Section: Introductionmentioning

confidence: 99%

Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence

Fabris

Karmelić

Muharemović

et al. 2021

IJMS

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Gangliosides serve as antitumor therapy targets and aberrations in their composition strongly correlate with tumor growth and invasiveness. Anaplastic ganglioglioma is a rare, poorly characterized, malignant neuronal–glial tumor type. We present the first comparative characterization of ganglioside composition in anaplastic ganglioglioma vs. peritumoral and healthy brain tissues by combining mass spectrometry and thin-layer chromatography. Anaplastic ganglioglioma ganglioside composition was highly distinguishable from both peritumoral and healthy tissue despite having five to six times lower total content. Ten out of twelve MS-identified ganglioside classes, defined by unique glycan residues, were represented by a large number and considerable abundance of individual species with different fatty acid residues (C16–C24) in ceramide portions. The major structurally identified class was tumor-associated GD3 (>50%) with 11 species; GD3 (d18:1/24:0) being the most abundant. The dominant sphingoid base residue in ganglioside ceramides was sphingosine (d18:1), followed by eicosasphingosine (d20:1). The peritumoral tissue ganglioside composition was estimated as normal. Specific ganglioside composition and large variability of ganglioside ceramide structures determined in anaplastic ganglioglioma demonstrate realistic ganglioside expression patterns and correspond to the profile of high-grade malignancy brain tumors.

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Uncommon low-grade brain tumors

Cited by 10 publications

References 78 publications

Preoperative neutrophil-to-lymphocyte ratio (preNLR) for the assessment of tumor characteristics in lung adenocarcinoma patients with brain metastasis

Preoperative neutrophil-to-lymphocyte ratio (preNLR) for the assessment of tumor characteristics in lung adenocarcinoma patients with brain metastasis

Imaging of supratentorial intraventricular masses in children: a pictorial review—part 2

Ganglioside Composition Distinguishes Anaplastic Ganglioglioma Tumor Tissue from Peritumoral Brain Tissue: Complementary Mass Spectrometry and Thin-Layer Chromatography Evidence

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