Rose Essential Oil Delayed Alzheimer’s Disease-Like Symptoms by SKN-1 Pathway in C. elegans

Abstract

There are no effective medications for delaying the progress of Alzheimer's disease (AD), the most common neurodegenerative disease in the world. In this study, our results with C. elegans showed that rose essential oil (REO) significantly inhibited AD-like symptoms of worm paralysis and hypersensivity to exogenous 5-HT in a dose-dependent manner. Its main components of β-citronellol and geraniol acted less effectively than the oil itself. REO significantly suppressed Aβ deposits and reduced the Aβ oligomers to alleviate the toxicity induced by Aβ overexpression. Additionally, the inhibitory effects of REO on worm paralysis phenotype were abrogated only after skn-1 RNAi but not daf-16 and hsf-1 RNAi. REO markedly activated the expression of gst-4 gene, which further supported SKN-1 signaling pathway was involved in the therapeutic effect of REO on AD C. elegans. Our results provided direct evidence on REO for treating AD on an organism level and relative theoretical foundation for reshaping medicinal products of REO in the future.

Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans

“…We observed that the methanol extract affected GST-4 expression and stress resistance in C. elegans via the SKN-1 signaling pathway. These effects are similar to some natural products including peptides from sesame and rose essential oils [31, 32]. Although the AO hexane extract did not affect SKN-1 nuclear localization, it induced GST-4 expression.…”

Antiaging, Stress Resistance, and Neuroprotective Efficacies ofCleistocalyx nervosumvar.panialaFruit Extracts UsingCaenorhabditis elegansModel

“…The activation of SKN-1 by C. nervosum could have played a major role in extending lifespan and healthspan along with improving stress resistance and neuroprotection [80]. Recent reports suggest that plant extracts and its derivatives such as Paullinia cupana [34], rose essential oils [81], and Cratoxylum formosum [82] were able to elicit neuroprotection which is mediated via SKN-1-regulated antioxidant response. However, further in-depth molecular studies are required to validate that these effects showed by C. nervosum extracts were dependent on SKN-1.…”

Potential of Caenorhabditis elegans as an antiaging evaluation model for dietary phytochemicals: A review

“…Treatment with chicoric acid upregulated the mRNA expression of aak‐2 and promoted SKN‐1 translocation from the cytoplasm to the nuclei in C. elegans (Peng et al., 2019). Rose essential oil ameliorated the toxicity of AD symptoms by suppressing Aβ deposits and reducing Aβ oligomers in nematodes, which was dependent on SKN‐1 but not on the DAF‐16 or HSF‐1 (Zhu et al., 2017). In addition, the function effect might not be attributable to the main components of the oil complex.…”

“…In addition, the function effect might not be attributable to the main components of the oil complex. β‐citronellol and geraniol were found to comprise 54.01 and 15.02% of rose essential oil, respectively; however, both exerted no therapeutic effects (Zhu et al., 2017). Panax notoginseng saponins were found to be major active ingredients of Radix notoginseng , which also exerted therapeutic effects on the AD C. elegans ( CL4176 ) involved with SKN‐1 signaling pathway (Zhou, Huang, Chen, & Wang, 2019).…”