Rose Bengal incorporated to α-cyclodextrin microparticles for photodynamic therapy against the cariogenic microorganism Streptococcus mutans

Alexandrino, Francisca Jamila Ricarte; Bezerra, Eveline M.; Costa, Roner F. da; Cavalcante, Letícia Régia Lima; Sales, Francisco Adilson Matos; Francisco, Telmo; Rodrigues, Lidiany Karla Azevedo; Brito, Débora Hellen Almeida de; Ricardo, Nágila Maria Pontes Silva; Costa, Stefane N.; Lima‐Neto, Pedro de; Caetano, E. W. S.; Freire, V. N.

doi:10.1016/j.pdpdt.2018.11.016

Cited by 18 publications

(12 citation statements)

References 48 publications

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“…The systematic review showed that among the cariogenic microorganisms listed in the selected studies, the most studied microorganism was Streptococcus mutans (82%) [12,14,15,16,17,18,19,20,21,23,24,25,26,27,28,29,31,32,33,34,35,37,39,40,41,42,43,45].…”

Section: Resultsmentioning

confidence: 99%

“…The most commonly used control group was a negative control with no intervention. In addition, few studies have reported whether the biofilm inhibitory capacity of this treatment modality was tested [27,35,41,45].…”

Section: Resultsmentioning

confidence: 99%

“…For a substance to be considered as a bactericide, it is necessary for a total inhibition of microorganism growth or ≤99.9% decrease in the initial inoculum (3-log 10 reduction in colony forming units [cfu]/mL) in the subculture [68]. From the 34 articles analyzed, only 11 presented a reduction greater than or equal to 99.9% [14,16,18,23,24,29,34,39,41,43,45]. This fact proves that eliminating these microorganisms is a great challenge, especially when they are in the biofilm.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Oliveira

Ferrisse

Marques

et al. 2019

IJMS

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The aim of this study was to perform a systematic review of the literature followed by a meta-analysis about the efficacy of photodynamic therapy (PDT) on the microorganisms responsible for dental caries. The research question and the keywords were constructed according to the PICO strategy. The article search was done in Embase, Lilacs, Scielo, Medline, Scopus, Cochrane Library, Web of Science, Science Direct, and Pubmed databases. Randomized clinical trials and in vitro studies were selected in the review. The study was conducted according the PRISMA guideline for systematic review. A total of 34 articles were included in the qualitative analysis and four articles were divided into two subgroups to perform the meta-analysis. Few studies have achieved an effective microbial reduction in microorganisms associated with the pathogenesis of dental caries. The results highlight that there is no consensus about the study protocols for PDT against cariogenic microorganisms, although the results showed the PDT could be a good alternative for the treatment of dental caries.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Oliveira

Ferrisse

Marques

et al. 2019

IJMS

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“…In the¯eld of antibiotics, studies have shown that bacteria do not produce photodynamic e®ects after repeated use of PDT. 6,7 so it is considered as a promising alternative way to kill antibiotic-resistant bacteria. Most of the photosensitizers commonly used in medical¯eld fall into the following two categories: (1) organic dyes and aromatic hydrocarbons; (2) porphyrin, phthalocyanine and related macrocyclins.…”

Section: Introductionmentioning

confidence: 99%

Effect of antibacterial photodynamic therapy on Streptococcus mutans plaque biofilm in vitro

Liang

Zou

et al. 2020

J. Innov. Opt. Health Sci.

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The main objective of this study is to evaluate the antibacterial effect of antibacterial photodynamic therapy (aPDT) on Streptococcus mutans (S. mutans) biofilm model in vitro. The selection of photosensitizers is the key step for the efficacy of photodynamic therapy (PDT). However, no studies have been conducted in the oral field to compare the functional characteristics and application effects of PDT mediated by various photosensitizers. In this research, the antibacterial effect of Methylene blue (MB)/650[Formula: see text]nm laser and Hematoporphyrin monomethyl ether (HMME)/532[Formula: see text]nm laser on S. mutans biofilm was compared under different energy densities to provide experimental reference for the clinical application of the two PDT. The yield of lactic acid was analyzed by Colony forming unit (CFU) and spectrophotometry, and the complete biofilm activity was measured by Confocal Laser Scanning Microscopy (CLSM) to evaluate the bactericidal effect on each group. Based on the results of CFU, the bacterial colonies formed by 30.4[Formula: see text]J/cm2 532[Formula: see text]nm MB-aPDT group and 30.4[Formula: see text]J/cm2 532[Formula: see text]nm HMME-aPDT group were significantly less than those in other groups, and the bacterial colonies in HMME-aPDT group were less than those in HMME-aPDT group. Lactic acid production in all treatment groups except the photosensitizer group was statistically lower than that in the normal saline control group. The activity of bacterial plaque biofilm was significantly decreased in the two groups treated with 30.4[Formula: see text]J/cm2 aPDT. Therefore, aPDT suitable for energy measurement can kill S. mutans plaque biofilm, and MB-aPDT is better than HMME-aPDT.

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“…The technique led to photoinactivation of the biofilm and reduced colony count and metabolic activity [44]. Similar effects were obtained using hypericin-glucamine [45], Rose Bengal in α-cyclodextrin [46], curcumin [44,[47][48][49][50], methylene blue [52], toluidine blue O [51], erythrosine with green light [55], or Photodithazine ® obtained from the cyanobacterium Spirulina platensis [53,54]. Another study conducted by Soria-Lozano et al [80], using Rose Bengal, methylene blue, and curcumin with white light, showed positive effects against the S. mutans and S. sanguis strains.…”

Section: Chemical Compounds With Activity Against Streptococcus Mutanmentioning

confidence: 66%

Management of Streptococcus mutans-Candida spp. Oral Biofilms’ Infections: Paving the Way for Effective Clinical Interventions

Salehi

Kręgiel

Mahady

et al. 2020

JCM

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Oral diseases are considered the most common noncommunicable diseases and are related to serious local and systemic disorders. Oral pathogens can grow and spread in the oral mucosae and frequently in biomaterials (e.g., dentures or prostheses) under polymicrobial biofilms, leading to several disorders such as dental caries and periodontal disease. Biofilms harbor a complex array of interacting microbes, increasingly unapproachable to antimicrobials and with dynamic processes key to disease pathogenicity, which partially explain the gradual loss of response towards conventional therapeutic regimens. New drugs (synthesized and natural) and other therapies that have revealed promising results for the treatment or control of these mixed biofilms are presented and discussed here. A structured search of bibliographic databases was applied to include recent research. There are several promising new approaches in the treatment of Candida spp.–Streptococcus mutans oral mixed biofilms that could be clinically applied in the near future. These findings confirm the importance of developing effective therapies for oral Candida–bacterial infections.

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Rose Bengal incorporated to α-cyclodextrin microparticles for photodynamic therapy against the cariogenic microorganism Streptococcus mutans

Cited by 18 publications

References 48 publications

Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Effect of antibacterial photodynamic therapy on Streptococcus mutans plaque biofilm in vitro

Management of Streptococcus mutans-Candida spp. Oral Biofilms’ Infections: Paving the Way for Effective Clinical Interventions

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