Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Oliveira, Analú Barros de; Ferrisse, Túlio Morandin; Marques, Raquel Souza; Annunzio, Sarah Raquel de; Brighenti, Fernanda Lourenção; Fontana, Carla Raquel

doi:10.3390/ijms20143585

Cited by 68 publications

(31 citation statements)

References 78 publications

(168 reference statements)

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“… 25–29 It is noteworthy that PDT is currently also used to treat some autoimmune 30 and infectious diseases. 31 32 Very recently, cetuximab saratolacan was approved by the Japanese government for the treatment of locally advanced or recurrent head and neck cancer. 33 This is the first PS conjugated to an antibody; it consists of the water-soluble silicon-phthalocyanine derivative, IRDye700DX (IR700), conjugated to cetuximab.…”

Section: Main Principles Of Pdtmentioning

confidence: 99%

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Alzeibak

Mishchenko

Shilyagina

et al. 2021

J Immunother Cancer

303

213

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The past decade has witnessed major breakthroughs in cancer immunotherapy. This development has been largely motivated by cancer cell evasion of immunological control and consequent tumor resistance to conventional therapies. Immunogenic cell death (ICD) is considered one of the most promising ways to achieve total tumor cell elimination. It activates the T-cell adaptive immune response and results in the formation of long-term immunological memory. ICD can be triggered by many anticancer treatment modalities, including photodynamic therapy (PDT). In this review, we first discuss the role of PDT based on several classes of photosensitizers, including porphyrins and non-porphyrins, and critically evaluate their potential role in ICD induction. We emphasize the emerging trend of ICD induction by PDT in combination with nanotechnology, which represents third-generation photosensitizers and involves targeted induction of ICD by PDT. However, PDT also has some limitations, including the reduced efficiency of ICD induction in the hypoxic tumor microenvironment. Therefore, we critically evaluate strategies for overcoming this limitation, which is essential for increasing PDT efficiency. In the final part, we suggest several areas for future research for personalized cancer immunotherapy, including strategies based on oxygen-boosted PDT and nanoparticles. In conclusion, the insights from the last several years increasingly support the idea that PDT is a powerful strategy for inducing ICD in experimental cancer therapy. However, most studies have focused on mouse models, but it is necessary to validate this strategy in clinical settings, which will be a challenging research area in the future.

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Section: Main Principles Of Pdtmentioning

confidence: 99%

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Alzeibak

Mishchenko

Shilyagina

et al. 2021

J Immunother Cancer

303

213

View full text Add to dashboard Cite

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“…(2) chemical [56][57][58]; (3) physical [59,60]; (4) physicochemical [61][62][63]; (5) physical in combination with natural [64], and (6) natural in combination with chemical [65]. A summary of the bacterial biofilm inhibition/control methods described in the past two years is shown in Figure 1.…”

Section: Biofilm Control Methodsmentioning

confidence: 99%

“…In order not to exclude search results that could be significant for the investigation, a general search term (keyword) "biofilm" was used. According to the scientific articles found in the PubMed database regarding biofilm inhibition and control, all methods, based on their nature, can be divided into six groups: (1) natural (biological) [53][54][55]; (2) chemical [56][57][58]; (3) physical [59,60]; (4) physicochemical [61][62][63]; (5) physical in combination with natural [64], and (6) natural in combination with chemical [65]. A summary of the bacterial biofilm inhibition/control methods described in the past two years is shown in Figure 1.…”

Section: Biofilm Control Methodsmentioning

confidence: 99%

Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft

Buchovec

Gricajeva

Kalėdienė

et al. 2020

IJMS

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A spacecraft is a confined system that is inhabited by a changing microbial consortium, mostly originating from life-supporting devices, equipment collected in pre-flight conditions, and crewmembers. Continuous monitoring of the spacecraft’s bioburden employing culture-based and molecular methods has shown the prevalence of various taxa, with human skin-associated microorganisms making a substantial contribution to the spacecraft microbiome. Microorganisms in spacecraft can prosper not only in planktonic growth mode but can also form more resilient biofilms that pose a higher risk to crewmembers’ health and the material integrity of the spacecraft’s equipment. Moreover, bacterial biofilms in space conditions are characterized by faster formation and acquisition of resistance to chemical and physical effects than under the same conditions on Earth, making most decontamination methods unsafe. There is currently no reported method available to combat biofilm formation in space effectively and safely. However, antibacterial photodynamic inactivation based on natural photosensitizers, which is reviewed in this work, seems to be a promising method.

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“…PDT that targets bacteria in particular is called antimicrobial photodynamic therapy (a-PDT). These therapies are beginning to be used to eliminate bacterial infections in periodontal disease [3][4][5][6], infected root canal treatment [7][8][9][10], and caries treatment [11][12][13][14]. There are three elements required for a-PDT: a photosensitizer, an excitation light, and oxygen.…”

Section: Introductionmentioning

confidence: 99%

Effects of Antimicrobial Photodynamic Therapy on Organic Solution and Root Surface In Vitro

et al. 2021

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Antimicrobial photodynamic therapy (a-PDT) is attracting attention as a new form of dental treatment. While it is primarily applied to produce an antibacterial effect, it decreases lipopolysaccharide (LPS) and protease activity. Here, we evaluated differences in the antibacterial activity of a-PDT on three types of bacteria and the effects on the organic substances (i.e., albumin and LPS). Furthermore, we investigated the effects of a-PDT on root surfaces. A FotoSan630® and toluidine blue were used to perform a-PDT in this study. We measured its antimicrobial activity against Porphyromonas gingivalis, Streptococcus mutans, and Enterococcus faecalis. Antimicrobial testing revealed strong antimicrobial action and P. gingivalis, E. faecalis, and S. mutans were almost undetectable after 50, 120, and 100 s, respectively. In organic resolution tests, albumin was significantly decreased from 1 min after a-PDT application onward, while LPS significantly decreased at 5 min after the application. The root surfaces after a-PDT were confirmed to be cleaner than the controls without suffering any damage. Depending on the bacterial species, a-PDT exhibited antimicrobial activity against various types of bacteria and sensitivity differed. Moreover, we reported that a-PDT resolves protein and LPS, enabling the formation of a healthy root surface without any damage.

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Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

Cited by 68 publications

References 78 publications

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future

Antimicrobial Photoinactivation Approach Based on Natural Agents for Control of Bacteria Biofilms in Spacecraft

Effects of Antimicrobial Photodynamic Therapy on Organic Solution and Root Surface In Vitro

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