“…These include (however are not restricted to): The notoriously known multidrug-resistant (MDRSA) and methicillin-resistant (MRSA) Staphylococcus aureus strains [ 6 ]; Staphylococcus epidermidis —for long thought to be a mere opportunistic microorganism, but recently shown to be implicated in medical device-related infections, keratitis, and bacteremia [ 7 ]; Clostridium difficile, which is considered one of the most frequent causes of hospital-acquired gastrointestinal tract infections [ 8 , 9 ]; different enterococci, some of which (e.g., Enterococcus faecalis and E. faecium ) can be responsible for bacteremia and endocarditis in addition to urinary tract, intra-abdominal, pelvic, and soft tissue infections [ 10 ]. Whereas some other (non-nosocomial) relevant Gram-positive pathogens worth a mention are Streptococcus mutans —associated with oral diseases and infective endocarditis [ 11 , 12 ]; Streptococcus pneumoniae —capable of causing pneumonia, meningitis, sepsis, bacteremia, and otitis [ 13 ]; Listeria monocytogenes —a significant cause of foodborne listeriosis outbreaks with a fatality rate of up to 30% [ 14 , 15 ]; causative agent of zoonotic anthrax— Bacillus anthracis , for which antibiotic resistance may not yet be an urgent matter, but potentially relevant [ 16 , 17 ].…”