ROS-mediated cytotoxic activity of ZnO and CeO2 nanoparticles synthesized using the Rubia cordifolia L. leaf extract on MG-63 human osteosarcoma cell lines

Natarajan, S.; Ramkumar, Vijayan Sri; Pugazhendhi, Arivalagan; Karthikeyan, Chandrasekaran; Karuppusamy, Indira; Gopinath, Kasi; Hameed, A.S. Haja; Basha, Mohamed Hussain Ghouse

doi:10.1007/s11356-017-0003-5

Cited by 122 publications

(44 citation statements)

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“…The compound adsorption capacities of NPs could be further improved by functionalization [ 217 ]. For instance, adsorption capacity of SiO 2 NPs towards quercetin was higher upon TiO 2 functionalization in comparison to non-functionalized and decyl group functionalized SiO 2 NPs due to possible binding of quercetin to the metal oxide [ 208 ]. This adsorption capacity increased linearly with surface coverage of TiO 2 , emphasizing the correlation between functional surface and quercetin adsorption.…”

Section: Potential Applications Of Green-synthesized Npsmentioning

confidence: 99%

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Marslin¹,

et al. 2018

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The ability of organisms and organic compounds to reduce metal ions and stabilize them into nanoparticles (NPs) forms the basis of green synthesis. To date, synthesis of NPs from various metal ions using a diverse array of plant extracts has been reported. However, a clear understanding of the mechanism of green synthesis of NPs is lacking. Although most studies have neglected to analyze the green-synthesized NPs (GNPs) for the presence of compounds derived from the extract, several studies have demonstrated the conjugation of sugars, secondary metabolites, and proteins in these biogenic NPs. Despite several reports on the bioactivities (antimicrobial, antioxidant, cytotoxic, catalytic, etc.) of GNPs, only a handful of studies have compared these activities with their chemically synthesized counterparts. These comparisons have demonstrated that GNPs possess better bioactivities than NPs synthesized by other methods, which might be attributed to the presence of plant-derived compounds in these NPs. The ability of NPs to bind with organic compounds to form a stable complex has huge potential in the harvesting of precious molecules and for drug discovery, if harnessed meticulously. A thorough understanding of the mechanisms of green synthesis and high-throughput screening of stabilizing/capping agents on the physico-chemical properties of GNPs is warranted to realize the full potential of green nanotechnology.

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Section: Potential Applications Of Green-synthesized Npsmentioning

confidence: 99%

Secondary Metabolites in the Green Synthesis of Metallic Nanoparticles

Marslin¹,

et al. 2018

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“…The study suggested increased ROS production as a mechanism of CeO 2 NPs cytotoxicity [27]. This observation was confirmed in another study which proved that zinc oxide nanoparticles (ZnONPs) could be harmful to MG63 as they triggered ROS production [28].…”

Section: Nanoparticles Cytotoxicity To Osteosarcoma Cellsmentioning

confidence: 61%

Modified Nanoparticles as Potential Agents in Bone Diseases: Cancer and Implant-Related Complications

Steckiewicz

Inkielewicz‐Stępniak

2020

Nanomaterials

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Materials sized 1–100 nm are the nanotechnology’s field of interest. Because of the unique properties such as the ability to penetrate biological barriers and a high surface to volume ratio, nanoparticles (NPs) are a powerful tool to be used in medicine and industry. This review discusses the role of nanotechnology in bone-related issues: osteosarcoma (bone cancer), the biocompatibility of the implants and implant-related infections. In cancer therapy, NPs can be used as (I) cytotoxic agents, (II) drug delivery platforms and (III) in thermotherapy. In implant-related issues, NPs can be used as (I) antimicrobial agents and (II) adjuvants to increase the biocompatibility of implant surface. Properties of NPs depend on (I) the type of NPs, (II) their size, (III) shape, (IV) concentration, (V) incubation time, (VI) functionalization and (VII) capping agent type.

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“…Several in vivo studies are carried out with plant crops like rice [79] , wheat, sunflower, pumpkin [80] , alfalfa, corn, tomato [81] , kidney bean [82] , radish [83] , [84] , cucumber [85] , Rubia cordifolia [86] to study the uptake of nanoceria. Results have shown the highest uptake in roots as compared to other parts of plants like leaves shoots etc.…”

Section: Antioxidant Activitymentioning

confidence: 99%