Roles of ultrasonography and computed tomography in the surgical management of cervical lymph node metastases in papillary thyroid carcinoma

Lee, D.W.; Ji, Yong Bae; Sung, Eui Suk; Park, J.S.; Lee, Y.J.; Park, D.W.; Tae, Kyung

doi:10.1016/j.ejso.2012.07.119

Cited by 120 publications

(106 citation statements)

References 27 publications

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“…Central nodes are usually non-palpable [19], and many previous studies have described US as virtually insensitive for detection of central compartment lymph node metastases with sensitivity ranging between 10% and 23% only [5,8,19]. In our study, US had a sensitivity of 62% for detection of nodal metastases in the central compartment, which is higher than many previous studies.…”

Section: Discussioncontrasting

confidence: 52%

“…Other studies with high specificity (97-99%) demonstrated very low sensitivity (11-23%) [5,8,19]. The US morphologic criteria of central lymph nodes in our study such as calcifications, cystic degeneration and abnormal vascularity were only seen with metastatic nodes and hence highly specific, but they were seen in a small proportion of lymph nodes, so that their sensitivity was very low, Table 1.…”

Section: Discussionmentioning

confidence: 65%

“…Firstly, the technical difficulty; where metastatic nodes may be masked by the enlarged thyroid gland and the multifocal nodules and the presence of many surrounding structures with poor acoustic transmission [19,20,22], figure 3. Secondly, it should be noted that the experience of radiologists in US imaging of the central neck compartment is lower than that in the lateral neck.…”

Section: Discussionmentioning

confidence: 99%

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Ultrasound Imaging of Nodal Metastases in the Central Compartment in Thyroid Cancer: is it Possible to Increase Sensitivity

Hafez¹

2015

Thyroid Disorders Ther

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Background and Purpose: Ultrasound imaging criteria for cervical lymph nodes were set mainly to increase sensitivity. However, unlike the lateral neck compartment, the challenge in the central compartment is the low sensitivity of Ultrasonography. We performed this study to evaluate whether the sensitivity of Ultrasonography could be increased by considering any detected lymph node in the central compartment as malignant.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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Ultrasound Imaging of Nodal Metastases in the Central Compartment in Thyroid Cancer: is it Possible to Increase Sensitivity

Hafez¹

2015

Thyroid Disorders Ther

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“…Roh et al [20] showed US specificity over 85% in all regions and levels of the neck. Lee et al [21] showed poor sensitivity of US and CT in central compartment, but proved these methods as useful in evaluation of lateral compartment LNs. However, lateral microscopic metastases can easily be overlooked by imaging methods [15,22,23].…”

Section: Resultsmentioning

confidence: 99%

Lymphatic drainage, regional metastases and surgical management of papillary thyroid carcinoma arising in pyramidal lobe – a single institution experience

et al. 2014

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“…When US was combined with CT to overcome these problems, sensitivity still remained low. Lee et al (14) studied 252 patients with PTC to detect cervical and lateral LNM, using a combined method of US and CT. In the central compartment, the sensitivity, specificity, and diagnostic accuracy were 46%, 88%, and 74%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of PET/MR for Evaluating Central Lymph Node Status in Patients with Papillary Thyroid Carcinoma

et al. 2017

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Purpose: Ultrasonography and computed tomography of the neck are commonly used for preoperative evaluation of neck lymph node (LN) status in papillary thyroid carcinoma (PTC). This study evaluated the accuracy of preoperative positron emission tomography/magnetic resonance (PET/MR) imaging of cervical LN status in PTC. F-fluorodeoxyglucose uptake and preoperative morphologic abnormalities of nodal shape, cortical thickness, and the fatty hilum of neck nodes were analyzed using PET/MR imaging. Results: Total thyroidectomy and lobectomy were conducted in 78.2% (223/285) and 21.8% (62/285) of cases, respectively. The status of central neck LN were evaluated in all patients during surgery and additional evaluation of lateral neck LN were conducted in 11.9% (34/285) of patients through selective sampling or modified radical neck dissection. In total, 36.1% (103/285) of patients had pathologic neck LN metastasis (LNM). PET/MR imaging showed an accuracy of 68.8%, sensitivity of 32.7%, and specificity of 88.6% for the detection of central neck LNM; moreover, an accuracy of 95.1%, sensitivity 68.4%, and specificity of 97.0% for lateral neck LNM. PET/MR imaging showed higher accuracy for detecting neck LNM in the 164 patients who did not have suspected clinical thyroiditis than others. Conclusion: PET/MR has a high specificity for detecting central LNM, especially for patients diagnosed with PTC without pathologic thyroiditis.

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Roles of ultrasonography and computed tomography in the surgical management of cervical lymph node metastases in papillary thyroid carcinoma

Cited by 120 publications

References 27 publications

Ultrasound Imaging of Nodal Metastases in the Central Compartment in Thyroid Cancer: is it Possible to Increase Sensitivity

Ultrasound Imaging of Nodal Metastases in the Central Compartment in Thyroid Cancer: is it Possible to Increase Sensitivity

Lymphatic drainage, regional metastases and surgical management of papillary thyroid carcinoma arising in pyramidal lobe – a single institution experience

Diagnostic Accuracy of PET/MR for Evaluating Central Lymph Node Status in Patients with Papillary Thyroid Carcinoma

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