Ultrasound Imaging of Nodal Metastases in the Central Compartment in Thyroid Cancer: is it Possible to Increase Sensitivity

Hafez, Mohamed T.

doi:10.4172/2167-7948.1000193

Cited by 2 publications

(2 citation statements)

References 22 publications

(34 reference statements)

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“…However, there is controversy regarding the value of preoperative US for the diagnosis of LNM. Some studies have obtained optimistic results, showing that the sensitivity and specificity of preoperative US in detecting central LNM were 62-95% and 75-90%, respectively (16,17). However, more studies have shown that the sensitivity of US in detecting central LNM was unsatisfactory (18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Thyroid Parenchyma Microcalcifications on Ultrasound for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Multicenter Study in China

Liu

Jia

et al. 2021

Front. Oncol.

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Objective: Cervical lymph node metastasis (LNM) was found to be clinically significant prognostic factors of patients with papillary thyroid carcinomas (PTC). Ultrasound (US) characteristics of thyroid nodules and thyroid parenchyma may be used to predict LNM. To investigate the value of nodular US features as well as thyroid parenchymal microcalcifications on US in predicting LNM in patients with PTC.Methods: This prospective study was approved by the Institutional Review Board. From January 2018 to June 2019, 971 consecutive patients with solitary PTC who underwent preoperative neck US evaluation were included from six hospitals in China. The US features of thyroid nodules as well as thyroid parenchyma microcalcifications were carefully evaluated based on the static images and dynamic clips. Univariate and multivariate analyses were performed to determine independent predictors of LNM.Results: Of the 971 patients, 760 were female, 211 were male. According to the pathological examination, 241(24.82%) patients were found with cervical LNM (LNM positive group), while 730 (75.18%) patients were not (LNM negative group). Multiple logistic regression analysis showed that young age (<55 years old) (OR = 1.522, P = 0.047), large size (>10 mm) (OR = 1.814, P < 0.001), intratumoral microcalcifications (OR = 1.782, P = 0.002) and thyroid parenchyma microcalcifications (OR = 1.635, P = 0.046) were independent risk factors for LNM of PTC.Conclusions: Young age, large nodule size, intratumoral microcalcifications, as well as thyroid parenchyma microcalcifications on US are independent predictors of cervical LNM for patients with PTC.

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Section: Introductionmentioning

confidence: 99%

Thyroid Parenchyma Microcalcifications on Ultrasound for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Multicenter Study in China

Liu

Jia

et al. 2021

Front. Oncol.

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“…However, lateral neck dissection is only done therapeutically in cases where there is confirmed nodal metastasis in the lateral compartment. Meanwhile, central compartment lymph node dissection (LND) is routinely performed in many institutions as a prophylactic measure to improve staging accuracy, reduce nodal recurrence risk, reduce thyroglobulin level postoperatively, and consequently avoid re-operation in the central neck 13 . Prophylactic neck dissection is limited only to the central compartment, and, on the other hand, therapeutic neck dissection is only performed when there is proof of metastatic lateral LNs involvement either radiologically or histopathologically 14 .…”

Section: Introductionmentioning

confidence: 99%

Skip Metastasis in Papillary Thyroid Cancer: Is it Predictable?

Hafez

Ahmed²,

Bahy³

et al. 2022

Kasr-Al-Aini J.of Clin. Onc. and Nuc. Med.

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Background: Cervical lymph node metastasis is a prognostic factor in papillary thyroid carcinoma (PTC). Metastasizing PTC to cervical lymph nodes is very common and occurs in 30-80% of patients. Aim: To investigate the risk factors of skip lateral lymph node metastasis in PTC patients. Methods: This retrospective study was conducted at a single institution and included PTC patients treated in the period between 2018 and 2021. All patients with PTC who underwent total thyroidectomy with central and lateral block neck dissection were reviewed for skip metastases which was confirmed by histopathologic examination. Results: During the study period, 267 patients with PTC underwent total thyroidectomy with central and/or lateral block neck dissection. Among them, only 64 patients matched the study inclusion criteria and their pathology was reviewed for skip metastases. Thirteen (20.3%) patients showed skip metastases. Their mean (±SD) age was 50.1 (±16.7) years and 8 (61.5%) were females. Only age ≥40 years and tumor size ≤0.5 cm differed significantly between patients with skip metastasis and those without. Conclusions: The results support the conduction of a prospective multi-centric study with a larger sample size to better understand the risk factors for developing skip metastasis in PTC. This would help in selecting patients with a risk for skip metastasis.

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Ultrasound Imaging of Nodal Metastases in the Central Compartment in Thyroid Cancer: is it Possible to Increase Sensitivity

Cited by 2 publications

References 22 publications

Thyroid Parenchyma Microcalcifications on Ultrasound for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Multicenter Study in China

Thyroid Parenchyma Microcalcifications on Ultrasound for Predicting Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Prospective Multicenter Study in China

Skip Metastasis in Papillary Thyroid Cancer: Is it Predictable?

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