Roles of Drinking Pattern and Type of Alcohol Consumed in Coronary Heart Disease in Men

Mukamal, Kenneth J.; Conigrave, Katherine M.; Mittleman, Murray A.; Camargo, Carlos A.; Stampfer, Meir J.; Willett, Walter C.; Rimm, Eric B.

doi:10.1056/nejmoa022095

Cited by 689 publications

(398 citation statements)

References 32 publications

Supporting

Mentioning

351

Contrasting

Unclassified

Order By: Relevance

“…Average and total alcohol consumption cannot distinguish the contribution of drinking days from that of nondrinking days. Previous epidemiological studies have reported that drinking patterns combining the weekly frequency of alcohol consumption and the quantity per drinking day were associated with the risk of diabetes, stroke, coronary heart disease, and cancer [12,13,14,15,16,17]. However, no studies have focused on drinking patterns in relation to the risk of CKD.…”

Section: Introductionmentioning

confidence: 99%

Drinking Pattern and Risk of Chronic Kidney Disease: The Kansai Healthcare Study

et al. 2014

View full text Add to dashboard Cite

Background/Aims: The association between alcohol consumption and the risk of chronic kidney disease (CKD) has been reported. What is not known is whether drinking pattern combined with the weekly frequency of alcohol consumption and the quantity per drinking day is associated with the risk of CKD. Methods: We enrolled 9,112 Japanese nondiabetic men aged 40 to 55 years with absence of proteinuria, an estimated glomerular filtration rate (eGFR) of 60 ml/min/1.73 m² or higher, and not on antihypertensive medications at baseline. CKD was defined if eGFR was <60 ml/min/1.73 m². The weekly frequency classification was nondrinkers, 1-3 drinking days/week, or 4-7 drinking days/week. The quantity consumed per drinking day was classified as 0.1-23.0 g ethanol/drinking day, 23.1-46.0 g ethanol/drinking day, 46.1-69.0 g ethanol/drinking day, and ≥69.1 g ethanol/drinking day. Results: During the 79,099 person-years, 1,253 subjects developed CKD. Compared to nondrinkers, those who consumed 23.1-46.0 or 46.1-69.0 g ethanol/drinking day on 4-7 drinking days/week had a decreased risk of CKD (multiple-adjusted hazard ratio (HR) 0.62 (0.52-0.74) and 0.76 (0.59-0.97), respectively). The association between the quantity per drinking day and the incidence of CKD was U-shaped among each category of the weekly frequency. HRs within similar categories of quantity per drinking day were lower in the 4-7 drinking days/week group than in the 1-3 drinking days/week group. Conclusion: Among middle-aged Japanese men, the people who drank middle-range quantity, specifically who drank 4-7 days/week, had lower risk of CKD than nondrinkers.

show abstract

Section: Introductionmentioning

confidence: 99%

Drinking Pattern and Risk of Chronic Kidney Disease: The Kansai Healthcare Study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Moreover, some studies have demonstrated a lower incidence of cardiovascular disease in people who drink red wine, compared to both drinkers of other alcoholic beverages and teetotalers [5,6,7]. The term ‘French paradox’ was coined after studies had shown that the French population who customarily consume red wine, despite having a high-fat diet and high frequency of smoking, had a much lower incidence of cardiovascular disease compared to the North American population [8].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol, a Polyphenolic Phytostilbene, Inhibits Endothelial Monocyte Chemotactic Protein-1 Synthesis and Secretion

Cullen

Morrow²,

Jin³

et al. 2006

J Vasc Res

View full text Add to dashboard Cite

Background/Aims: Resveratrol is a naturally occurring polyphenol phytoestrogen and one of several constituents of red wine thought to be cardioprotective. We investigated the effect of resveratrol on the expression of the atherogenic chemokine, monocyte chemotactic protein-1 (MCP-1). Methods: Human umbilical vein endothelial cells were stimulated with interleukin-1β (IL-1β) in the absence or presence of resveratrol. MCP-1 levels were determined by ELISA and MCP-1 mRNA was measured. Results: Resveratrol (1–100 µM) dose-dependently inhibited IL-1β-stimulated MCP-1 secretion, with ∼45% inhibition at 50 µM resveratrol. This was a Gi-protein- and NO-dependent effect. Resveratrol also significantly inhibited MCP-1 gene expression in a Gi-protein-dependent but NO-independent manner. While resveratrol had no effect on MCP-1 mRNA degradation, it inhibited MCP-1 promoter activity and reduced nuclear factor ĸB and activator protein-1 binding activity induced by IL-1β. Moreover, while hemoxygenase-1 (HO-1) expression was induced by resveratrol in human umbilical vein endothelial cells, neither treatment with the HO-1 inhibitor tin-protoporphyrin IX nor siRNA-directed knockdown of HO-1 had any effect on the inhibition of MCP-1 mRNA or protein secretion by resveratrol. Conclusion: These data demonstrate an inhibitory effect of resveratrol on MCP-1 synthesis and secretion, mediated via distinct signaling pathways. The inhibition of MCP-1 may represent a novel cardioprotective mechanism of resveratrol.

show abstract

“…It should be stressed that of the addictions analyzed in the study, drinking wine appeared to have a significant and positive effect on premature deaths. Much research states that drinking in moderation has reduced a number of deaths, especially due to heart diseases [95][96][97]. Some studies point out the influence of a diet and analyze effects of obesity [98][99][100][101].…”

Section: Resultsmentioning

confidence: 99%

Determinants of premature mortality in a city population: An eight-year observational study concerning subjects aged 18–64

Maniecka-Bryła¹,

Dziankowska-Zaborszczyk²,

Bryła³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

View full text Add to dashboard Cite

Background: Premature deaths constitute 31.1% of all deaths in Łódź. Analysis of the causes of premature deaths may be helpful in the evaluation of health risk factors. Moreover, findings of this study may enhance prophylactic measures. Material and Methods: In 2001, 1857 randomly selected citizens, aged 18-64, were included in the Countrywide Integrated Noncommunicable Diseases Intervention (CINDI) Programme. In 2009, a follow-up study was conducted and information on the subjects of the study was collected concerning their health status and if they continued to live in Łódź. The Cox proportional hazards model was used for evaluation of hazard coefficients. We adjusted our calculations for age and sex. The analysis revealed statistically significant associations between the number of premature deaths of the citizens of Łódź and the following variables: a negative self-evaluation of health -HR = 3.096 (95% CI: 1.729-5.543), poor financial situation -HR = 2.811 (95% CI: 1.183-6.672), occurring in the year preceding the study: coronary pain -HR = 2.754 (95% CI: 1.167-6.494), depression -HR = 2.001 (95% CI: 1.222-3.277) and insomnia -HR = 1.660 (95% CI: 1.029-2.678). Our research study also found a negative influence of smoking on the health status -HR = 2.782 (95% CI: 1.581-4.891). Moreover, we conducted survival analyses according to sex and age with Kaplan-Meier curves. Conclusions: The risk factors leading to premature deaths were found to be highly significant but possible to reduce by modifying lifestyle-related health behaviours. The confirmed determinants of premature mortality indicate a need to spread and intensify prophylactic activities in Poland, which is a post-communist country, in particular, in the field of cardiovascular diseases. Attempts to find reasons of deaths in the first decade of the 21st century may lead to a detailed and long-term research which would focus on determining a wide spectrum of factors contributing to the mortality of Łódź citizens. This in turn, may lead to implementation of a multidimensional prophylaxis which would contribute to improving the state of health of the inhabitants of Łódź as well as other cities and industrial populations, where the population of Łódź may act as a representative. THE AIM OF THE STUDYThe study aimed at listing factors which determine premature mortality of the citizens of Łódź, basing on the results of empirical data the sources of which are multidirectional epidemiological studies. Researchers attempt to identify factors influencing the phenomenon of premature deaths.

show abstract

Roles of Drinking Pattern and Type of Alcohol Consumed in Coronary Heart Disease in Men

Cited by 689 publications

References 32 publications

Drinking Pattern and Risk of Chronic Kidney Disease: The Kansai Healthcare Study

Drinking Pattern and Risk of Chronic Kidney Disease: The Kansai Healthcare Study

Resveratrol, a Polyphenolic Phytostilbene, Inhibits Endothelial Monocyte Chemotactic Protein-1 Synthesis and Secretion

Determinants of premature mortality in a city population: An eight-year observational study concerning subjects aged 18–64

Contact Info

Product

Resources

About