Drinking Pattern and Risk of Chronic Kidney Disease: The Kansai Healthcare Study

Satō, Kyoko; Hayashi, Tomoshige; Uehara, Shinichiro; Kinuhata, Shigeki; Oue, Keiko; Endo, Ginji; Kambe, Hiroshi; Fukuda, Kanji

doi:10.1159/000370051

Cited by 27 publications

(39 citation statements)

References 24 publications

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“…24 We found that subjects who had an alcohol consumption of 23.1–46.0 or 46.1–69.0 g ethanol/drinking day on 4–7 days per week showed a significantly lower risk of developing CKD compared with non-drinkers. However, alcohol consumption of ≥69.1 g ethanol/drinking day was not associated with risk of CKD, regardless of the number of drinking days per week.…”

Section: Discussionmentioning

confidence: 71%

Relationship Between Alcohol Drinking Pattern and Risk of Proteinuria: The Kansai Healthcare Study

Uehara

Hayashi

Satō

et al. 2016

Journal of Epidemiology

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BackgroundModerate alcohol consumption has been reported to be associated with a decreased risk of cardiometabolic diseases. Whether drinking pattern is associated with the risk of proteinuria is unknown.MethodsStudy subjects were 9154 non-diabetic Japanese men aged 40–55 years, with an estimated glomerular filtration rate ≥60 mL/min/1.73 m2, no proteinuria, and no use of antihypertensive medications at entry. Data on alcohol consumption were obtained by questionnaire. We defined “consecutive proteinuria” as proteinuria detected twice consecutively as 1+ or higher on urine dipstick at annual examinations.ResultsDuring the 81 147 person-years follow-up period, 385 subjects developed consecutive proteinuria. For subjects who reported drinking 4–7 days per week, alcohol consumption of 0.1–23.0 g ethanol/drinking day was significantly associated with a decreased risk of consecutive proteinuria (hazard ratio [HR] 0.54; 95% confidence interval [CI], 0.36–0.80) compared with non-drinkers. However, alcohol consumption of ≥69.1 g ethanol/drinking day was significantly associated with an increased risk of consecutive proteinuria (HR 1.78; 95% CI, 1.01–3.14). For subjects who reported drinking 1–3 days per week, alcohol consumption of 0.1–23.0 g ethanol/drinking day was associated with a decreased risk of consecutive proteinuria (HR 0.76; 95% CI, 0.51–1.12), and alcohol consumption of ≥69.1 g ethanol/drinking day was associated with an increased risk of consecutive proteinuria (HR 1.58; 95% CI, 0.72–3.46), but these associations did not reach statistical significance.ConclusionsMen with frequent alcohol consumption of 0.1–23.0 g ethanol/drinking day had the lowest risk of consecutive proteinuria, while those with frequent alcohol consumption of ≥69.1 g ethanol/drinking day had an increased risk of consecutive proteinuria.

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Section: Discussionmentioning

confidence: 71%

Relationship Between Alcohol Drinking Pattern and Risk of Proteinuria: The Kansai Healthcare Study

Uehara

Hayashi

Satō

et al. 2016

Journal of Epidemiology

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“…33 On the other hand, alcohol consumption has been inversely associated with the risk of CKD. [25][26][27][35][36][37] A prospective cohort study of 11 023 initially healthy male physicians in the United States reported a significantly lower risk of renal dysfunction (defined as serum creatinine ⩾ 1.5 mg/dl and eGFR ⩽ 55 ml/min) in those who consumed at least 7 drinks weekly. 37 A prospective cohort study in China reported a significant inverse relationship between alcohol consumption and risk of ESRD in men and a stronger relationship in those who had more than 21 drinks weekly.…”

Section: Discussionmentioning

confidence: 99%

The association of alcohol and smoking with CKD in a Japanese nationwide cross-sectional survey

et al. 2017

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Chronic kidney disease (CKD) is characterized by a reduced glomerular filtration rate (GFR) and proteinuria. Modifiable lifestyle factors such as smoking and alcohol contribute to CKD. Recent cohort studies have shown that moderate alcohol consumption attenuates the decline of the GFR and smoking has been previously shown to be associated with CKD. However, the association of smoking and alcohol consumption on CKD is not entirely clear. To examine whether there is evidence to assume that smoking is an effective modifier of the association between CKD and alcohol consumption, we conducted a cross-sectional study of a population of people who presented for a health checkup under a program that targets the insured population aged ≧ 40 years using data from the Specific Health Check and Guidance in Japan between April 2008 and March 2009. Of the 506 807 participants aged ⩾ 40 years, 292 013 (57.6%) were included in the present analysis. Outcomes were kidney dysfunction, as an eGFR of o60 ml/min/1.73 m 2 , and proteinuria. In nonsmokers, drinking a small amount was associated with a lower prevalence of proteinuria, but in smokers, the association between alcohol and proteinuria was not observed. The analysis regarding eGFR o60 ml/min/1.73 m 2 revealed that in both smokers and nonsmokers, alcohol consumption was inversely associated with the risk of CKD. Mild to moderate alcohol consumption might be associated with a lower risk of CKD (proteinuria and eGFR), especially among nonsmokers, because smoking might have modified the potential benefits of alcohol to prevent CKD.

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“…In contrast, several previous epidemiological studies have showed that moderate alcohol consumption was associated with a decreased risk of CKD [17][18][19]29], although the serum uric acid levels increase with increasing alcohol consumption [6][7][8][9][10]. Therefore, an adjustment for alcohol consumption is necessary for a more accurate assessment of the effect of serum uric acid level on the incident CKD.…”

Section: Discussionmentioning

confidence: 91%

Habitual Alcohol Intake Modifies Relationship of Uric Acid to Incident Chronic Kidney Disease

et al. 2019

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Background: Previous studies showed that higher serum uric acid levels increased the risk of chronic kidney disease (CKD), but moderate alcohol consumption decreased it. The comparative importance of serum uric acid levels and habitual alcohol consumption as risk factors for CKD remain undefined. We therefore evaluated the relationship of baseline serum uric acid level in combination with daily alcohol consumption to the incidence of CKD. Methods: A prospective cohort study of 9,116 middle-aged nondiabetic Japanese men without CKD nor proteinuria who were not taking antihypertensive medications nor urate-lowering medications at entry. CKD was defined as estimated glomerular filtration rate <60 mL/min/1.73 m². We investigated the relationship of baseline serum uric acid level in combination with daily alcohol consumption to the incidence of CKD during an 11-year observation period. Daily alcohol consumption was classified into 4 groups: nondrinkers, light drinkers (0.1–23.0 g ethanol/day), moderate drinkers (23.1–46.0 g ethanol/day), and heavy drinkers (≥46.1 g ethanol/day). Cox proportional hazards models were used in multivariate analysis. Results: During the 79,361 person-years follow-up period, a total of 1,230 subjects developed CKD. In multivariate models, higher serum uric acid levels increased risk of CKD; and moderate daily alcohol consumption decreased the risk. Multiple-adjusted hazard ratios of CKD were 1.38 (95% CI 1.11–1.70), 1.58 (95% CI 1.28–1.95), 2.27 (95% CI 1.86–2.77), and 3.12 (95% CI 2.56–3.81) for quintile 2, quintile 3, quintile 4, and quintile 5 of serum uric acid levels, respectively, compared with quintile 1, and that for moderate drinkers was 0.55 (95% CI 0.46–0.66) compared with nondrinkers. In the joint analysis of alcohol consumption and serum uric acid, moderate drinkers with the lowest tertile of serum uric acid levels had the lowest risk of CKD, but nondrinkers with the highest tertile of serum uric acid levels had the highest risk of CKD. Conclusions: Serum uric acid level and daily alcohol consumption were independently associated with the risk of CKD. Nondrinkers with the highest serum uric acid level had the highest risk of CKD.

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Drinking Pattern and Risk of Chronic Kidney Disease: The Kansai Healthcare Study

Cited by 27 publications

References 24 publications

Relationship Between Alcohol Drinking Pattern and Risk of Proteinuria: The Kansai Healthcare Study

Relationship Between Alcohol Drinking Pattern and Risk of Proteinuria: The Kansai Healthcare Study

The association of alcohol and smoking with CKD in a Japanese nationwide cross-sectional survey

Habitual Alcohol Intake Modifies Relationship of Uric Acid to Incident Chronic Kidney Disease

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