Roles and mechanisms of miR-195–5p in human solid cancers

Xu, Qi; Chen, Wenquan; Xu, Wen‐Xiu; Song, Yuxin; Tang, Wenjuan; Xu, Di; Jiang, Meng-Ping; Tang, Jinhai

doi:10.1016/j.biopha.2022.112885

Cited by 21 publications

(16 citation statements)

References 113 publications

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“…Several studies have confirmed that miR-195 is downregulated in carcinoma tissues, for example, the most recent studies of Li et al [ 33 ], found that it was downregulated in squamous cell carcinoma of the esophagus, while a recent review of the literature conducted by Xu et al [ 34 ], they found that it downregulated in very many solid tumors, indicating that its overexpression is generally associated with a tumor growth inhibition effect.…”

Section: Discussionmentioning

confidence: 97%

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Is the Non-Coding RNA miR-195 a Biodynamic Marker in the Pathogenesis of Head and Neck Squamous Cell Carcinoma? A Prognostic Meta-Analysis

Dioguardi

Spirito

Caloro

et al. 2023

JPM

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Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of neoplasms whose histological derivation comes from the mucous membranes lining the epithelium: the oral cavity, the larynx, the hypopharynx, the nasopharynx, and the oropharynx. The etiopathogenetic mechanisms involving tumor genesis including the alteration of cell proliferation, apoptosis, invasion, migration, and death may involve alterations in the expression of microRNA (miR). To date there have been no systematic reviews with meta-analysis conducted specifically on the role of miR-195 in HNSCC; therefore, our hypothesis was to evaluate if the aberrant expression of miR-195 in HNSCC tissues may represent a prognostic biomarker of survival through the hazard ratio (HR) and relative risk (RR) analysis. The systematic review was designed according to the PRISMA indications; in total, three electronic databases were consulted (PubMed, Scopus, Cochrane Central Trial) including Google Scholar and the gray literature, and a combination of keywords was used such as miR-195 AND HNSCC, microRNA AND HNSCC and miR-195. The meta-analysis and trial sequential analysis were performed using RevMan 5.41 software and TSA software (Cochrane Collaboration, Copenhagen, Denmark). This search identified 1592 articles and, at the end of the selection process, three articles were included. The results of the meta-analysis reported an aggregated risk ratio for overall survival (OS) between the expression of miR-195 at the highest and lowest of 0.36 and 6, respectively, 95% CI: [0.25, 0.51]. Heterogeneity was evaluated through Chi2 = 0.05 df = 2 (p = 0.98) and the Higgins index I2 = 0%. The test for the overall effect was Z = 5.77 (p < 0.00001). The forest plot was in favor of higher OS in patients with high miR-195 expression.

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Section: Discussionmentioning

confidence: 97%

“…For head and neck HNSCCs, Ding and Qi [ 34 ], reported that miRNA-195 expression was downregulated in LSCC tissue, and that low miRNA-195 expression may be related to laryngeal cancer invasion and metastasis, a poor prognosis indicator [ 31 ]. Even for LSCC, there exists unfavorable prognosis data, according to Shuang et al [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Is the Non-Coding RNA miR-195 a Biodynamic Marker in the Pathogenesis of Head and Neck Squamous Cell Carcinoma? A Prognostic Meta-Analysis

Dioguardi

Spirito

Caloro

et al. 2023

JPM

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“…In terms of the classification of miRNAs into oncogenic and tumor-suppressive groups, all three miRNAs included in the most effective mixture predominantly possess tumor-suppressive activity. For instance, according to the literature, miR-195–5p is a promising biomarker and a potential therapeutic target for the development of anticancer drugs . By blocking PI3K/AKT, MAPK, TNF, Hippo, Wnt/β-catenin, JAK–STAT, and Notch signaling pathways, miR-195–5p represses the proliferation, migration, and invasiveness of tumor cells in cancers of various organs. − This miRNA has been reported to regulate the proliferation, invasiveness, and apoptosis of cells of thyroid cancer and melanoma through an impact on the expression of the TERT gene.…”

Section: Discussionmentioning

confidence: 99%

Prevention of Metastasis by Suppression of Stemness Genes Using a Combination of microRNAs

Nevskaya,

Pershina,

Hmelevskaya

et al. 2024

J. Med. Chem.

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We propose an original strategy for metastasis prevention using a combination of three microRNAs that blocks the dedifferentiation of cancer cells in a metastatic niche owing to the downregulation of stemness genes. Transcriptome microarray analysis was applied to identify the effects of a mixture of microRNAs on the pattern of differentially expressed genes in human breast cancer cell lines. Treatment of differentiated CD44– cancer cells with the microRNA mixture inhibited their ability to form mammospheres in vitro. The combination of these three microRNAs encapsulated into lipid nanoparticles prevented lung metastasis in a mouse model of spontaneous metastasis. The mixture of three microRNAs (miR-195–5p/miR-520a/miR-630) holds promise for the development of an antimetastatic therapeutic that blocks tumor cell dedifferentiation, which occurs at secondary tumor sites and determines the transition of micrometastases to macrometastases.

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“…Many studies con rm that miR-195 is downregulated in carcinoma tissues (29), for example citing the most recent studies, Li et al nds it downregulated in squamous cell carcinoma of the esophagus (29), while a recent review of the literature conducted by Xu et al nds it downregulated in very many solid tumors indicating that its overexpression is generally associated with a tumor growth inhibition effect (30).…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Role of miR-195 in Head and Neck Squamous Cell Carcinoma: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Dioguardi

Spirito

Sovereto

et al. 2022

Preprint

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Head and neck squamous cell carcinoma (HNSCC) represent a heterogeneous group of neoplasms whose histological derivation comes from the lining epithelium of the mucous membranes: the oral cavity, the larynx, the hypopharynx, the nasopharynx and the oropharyx The etiopathogenetic mechanisms involving tumor genesis, including alteration of cell proliferation, apoptosis, invasion, migration and death, may involve alterations in the expression of MICRORNA. To date there are no systematic reviews with meta-analyzes conducted specifically on the role of miR-195 in HNSCC, our hypothesis is that with the presence in the literature of recent studies conducted on miR-195 it is possible to clearly determine, by aggregating the results, if the aberrant expression of miR-195 in HNSCC tissues may represent a prognostic biomarker of survival through Hazard Ratio (HR) and RR analysis. The systematic review was reported following the indications of the PRISMA and 3 electronic databases were used, such as PubMed, Scopus and Chocrane central Trial and the gray literature and a combination of keywords was used, such as miR-195 AND HNSCC, microRNA AND HNSCC and miR − 195. The meta-analysis and Trial sequential analysis were performed using RevMan 5.41 software and TSA software (Cochrane Collaboration, Copenhagen, Denmark). This search identified 1592 articles, at the end of the selection process 3 articles were included. The results of the meta-analysis report an aggregate risk ratio (RR) for overall survival (OS), between the expression of miR-195 highest and lowest, of 0.36, 6 95% CI: [0.25, 0.51] heterogeneity was evaluated through Chi² = 0.05 df = 2 (P = 0.98) and the Higgins index I² = 0% ; The test for the overall effect is Z = 5.77 (P < 0.00001). the forest plot is in favor of higher OS in patients with high miR-195 expression.

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Roles and mechanisms of miR-195–5p in human solid cancers

Cited by 21 publications

References 113 publications

Is the Non-Coding RNA miR-195 a Biodynamic Marker in the Pathogenesis of Head and Neck Squamous Cell Carcinoma? A Prognostic Meta-Analysis

Is the Non-Coding RNA miR-195 a Biodynamic Marker in the Pathogenesis of Head and Neck Squamous Cell Carcinoma? A Prognostic Meta-Analysis

Prevention of Metastasis by Suppression of Stemness Genes Using a Combination of microRNAs

The Prognostic Role of miR-195 in Head and Neck Squamous Cell Carcinoma: Systematic Review with Meta-Analysis and Trial Sequential Analysis

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