The Prognostic Role of miR-195 in Head and Neck Squamous Cell Carcinoma: Systematic Review with Meta-Analysis and Trial Sequential Analysis

Abstract

Head and neck squamous cell carcinoma (HNSCC) represent a heterogeneous group of neoplasms whose histological derivation comes from the lining epithelium of the mucous membranes: the oral cavity, the larynx, the hypopharynx, the nasopharynx and the oropharyx The etiopathogenetic mechanisms involving tumor genesis, including alteration of cell proliferation, apoptosis, invasion, migration and death, may involve alterations in the expression of MICRORNA. To date there are no systematic reviews with meta-analyzes conducted specifically on the role of miR-195 in HNSCC, our hypothesis is that with the presence in the literature of recent studies conducted on miR-195 it is possible to clearly determine, by aggregating the results, if the aberrant expression of miR-195 in HNSCC tissues may represent a prognostic biomarker of survival through Hazard Ratio (HR) and RR analysis. The systematic review was reported following the indications of the PRISMA and 3 electronic databases were used, such as PubMed, Scopus and Chocrane central Trial and the gray literature and a combination of keywords was used, such as miR-195 AND HNSCC, microRNA AND HNSCC and miR − 195. The meta-analysis and Trial sequential analysis were performed using RevMan 5.41 software and TSA software (Cochrane Collaboration, Copenhagen, Denmark). This search identified 1592 articles, at the end of the selection process 3 articles were included. The results of the meta-analysis report an aggregate risk ratio (RR) for overall survival (OS), between the expression of miR-195 highest and lowest, of 0.36, 6 95% CI: [0.25, 0.51] heterogeneity was evaluated through Chi² = 0.05 df = 2 (P = 0.98) and the Higgins index I² = 0% ; The test for the overall effect is Z = 5.77 (P < 0.00001). the forest plot is in favor of higher OS in patients with high miR-195 expression.

The association of ethnicity and oncologic outcomes for oral cavity squamous cell carcinoma (OSCC)

“…Upregulation of miRNAs is thought to contribute to OSCC resistance to chemoradiation and recurrence (41). Our centre is involved in banking the tumors of all consecutive OSCC patients and intends to explore the potential molecular basis of poor OSCC outcomes in the SA population.…”