Role of vitamin D receptor (VDR) genetic polymorphism in onset of type 2 diabetes mellitus: A Review

Sattar, Naila Abdul; Hussain, Fatma; Gillespie, Kathleen M.; Sajid, Siraj Udin; Shaheen, Sumera; Shafiq, Nusrat; Aleem, Sobia; Aslam, Sadia

doi:10.31248/jbbd2018.077

Cited by 2 publications

(7 citation statements)

References 72 publications

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“…The vitamin D genomic action begins when 1,25(OH)2D3 binds to VDR, which then interacts with the retinoid X receptor (RXR) to form a VDR/RXR heterodimer binding to vitamin D-responsive elements (VDRE). 6,26,27 This process initiates several gene expressions in various types of cells and synthesizes proteins in different cellular processes. 2,4,26 VDR is found in the nucleus of cells involved in calcium and phosphate metabolism.…”

Section: Vitamin D -Mechanism Of Actionmentioning

confidence: 99%

“…6,26,27 This process initiates several gene expressions in various types of cells and synthesizes proteins in different cellular processes. 2,4,26 VDR is found in the nucleus of cells involved in calcium and phosphate metabolism. 26 These cells include keratinocytes, hepatocytes, pancreatic and immune system cells such as macrophages, and monocytes.…”

Section: Vitamin D -Mechanism Of Actionmentioning

confidence: 99%

“…2,4,26 VDR is found in the nucleus of cells involved in calcium and phosphate metabolism. 26 These cells include keratinocytes, hepatocytes, pancreatic and immune system cells such as macrophages, and monocytes. 10,26 Vitamin D activity is also determined by VDREs found in several human genes involved in cell proliferation, differentiation, and apoptosis.…”

Section: Vitamin D -Mechanism Of Actionmentioning

confidence: 99%

“…One example is peroxisome proliferator-activated receptor gamma (PPAR-γ), which plays a role in glucose homeostasis, lipid metabolism, and adipokine regulation, affecting insulin sensitivity. 26 The number of cellular components is influenced by VDRE, which underlies vitamin D involvement in various disease pathogenesis, including cancer, autoimmune diseases, cardiovascular disease, and infections. 4,26 Vitamin D also controls the oxidative stress level in the body, which affects the aging process and degenerative diseases such as diabetes mellitus, heart disease, and dementia.…”

Section: Vitamin D -Mechanism Of Actionmentioning

confidence: 99%

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Vitamin D and Its Role in Modulating Immune System: A Narrative Literature Review

Rizkia

2023

OAIJMR

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Vitamin D is recognized for its pivotal role in maintaining calcium-phosphorus homeostasis and regulating bone metabolism. The beneficial effects of vitamin D on the protective function of the immune system are seen in the innate immune system. It increases the production of defensin β2 and cathelicidin by macrophages, monocytes, and keratinocytes in response to infection. Cathelicidin is produced by neutrophils, macrophages, and cells lining epithelial surfaces such as skin, respiratory, and digestive tracts. Recent research showed that vitamin D exerts potent immunomodulatory effects by modulating the innate and adaptive immune systems. This led to the recognition of various disease conditions associated with vitamin D deficiency. This narrative review aimed to describe the molecular mechanisms for the vitamin D immunomodulatory effect.

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Section: Vitamin D -Mechanism Of Actionmentioning

confidence: 99%

Section: Vitamin D -Mechanism Of Actionmentioning

confidence: 99%

Section: Vitamin D -Mechanism Of Actionmentioning

confidence: 99%

Section: Vitamin D -Mechanism Of Actionmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin D and Its Role in Modulating Immune System: A Narrative Literature Review

Rizkia

2023

OAIJMR

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“…Vitamin D, known as the sunshine vitamin, has been understood as an important key for controlling inflammation of endothelial cells, through Vitamin D receptors (VDRs). Hypo vitamin D and VDR polymorphisms are strongly associated with diabetes and cardiovascular diseases [6], [7], [8], [9]. The genetic role of Vitamin D in T2DM has been well-demonstrated, and different variants of VDR gene FokI are associated with T2DM [10], [11], [12], [13].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Receptor Gene Polymorphism FokI and 25-Hydroxy Vitamin D Levels among Indonesian Diabetic Foot Patients

Raflis

Yuwono

Yanwirasti

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: Vitamin D and VDRs FokI has been reported to be strongly associated with type 2 diabetes mellitus (T2DM) through controlling inflammation of endothelial cells in diabetic foot cases. AIM: This study aimed to detect Vitamin D receptor FokI polymorphisms and to determine the Vitamin D levels among diabetic foot patients in sunlight-rich areas. MATERIALS AND METHODS: A cross sectional study was conducted among diabetic foot patients who were treated as T2DM, from November 2016 to June 2018 in Padang city, Indonesia. There are an inclusion and exclusion criteria listed below. A questionnaire for symptoms-based screening, ankle brachial index (ABI) examination, fasting glucose, and HbA1c were measured. Electroimmunoassay (ECLIA) was used to determine Vitamin D levels as sufficiency, insufficiency, and deficiency. Polymerase chain reaction assay was addressed for VDR FokI genetic polymorphisms. Data were analyzed to evaluate the differences of explanatory variables (age, gender, duration of T2DM, fasting blood sugar, body mass index [BMI], HbA1c, and Vitamin D levels) across different genotypes of VDR FokI for three groups based on the absent T allele (ff: wild type homozygous, Ff: mutant heterozygous, and FF: mutant homozygous). RESULTS: Among 36 eligible subjects, 52.8% were females, 61.1% were <50 years old, 63.9% had normal BMI, and 86.1% had normal ABI. Vitamin D deficiency, insufficiency, and sufficiency were shown in 19.4%, 33.3%, and 47.2% of the subjects, respectively. The majority of VDR FokI gene polymorphisms were mutant heterozygous Ff (44.4%), wild type homozygous ff (13.9%), and mutant homozygous FF (41.7%). Results of one-way ANOVA showed that there were no differences of BMI, ABI, fasting blood glucose, Vitamin D levels, and Hb1AC status with the VDR FokI gene polymorphisms. Based on Vitamin D levels, most of the Vitamin D deficiency subjects had 31.2% VDR FokI Ff allele, 13.3% had FF allele, and none of them had ff allele. CONCLUSION: This study concluded that most of the individuals with diabetic foot in a sunlight-rich area tended to have mutant VDR FokI polymorphisms and Vitamin D insufficiency.

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Role of vitamin D receptor (VDR) genetic polymorphism in onset of type 2 diabetes mellitus: A Review

Cited by 2 publications

References 72 publications

Vitamin D and Its Role in Modulating Immune System: A Narrative Literature Review

Vitamin D and Its Role in Modulating Immune System: A Narrative Literature Review

Vitamin D Receptor Gene Polymorphism FokI and 25-Hydroxy Vitamin D Levels among Indonesian Diabetic Foot Patients

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