Role of vagus nerves in experimental asthma in allergic dogs.

Gold, Warren M.; Kessler, G; Yu, D. Y. C.

doi:10.1152/jappl.1972.33.6.719

Cited by 244 publications

(90 citation statements)

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“…It has been suggested that vagal reflexes are partly responsible for anaphylactic bronchoconstriction in guinea-pigs (Mills & Widdicombe, 1970), dogs (Gold, Kessler & Yu, 1972) and rabbits (Karczewski & Widdicombe, 1969). In our experiments, vagotomy did not modify PLA in the rat.…”

Section: Discussionsupporting

confidence: 45%

Mediators of Passive Lung Anaphylaxis in the Rat

Farmer¹,

Richards²,

Sheard³

et al. 1975

British J Pharmacology

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1 Passive lung anaphylaxis (PLA) was investigated in rats sensitized by the intravenous injection of high titre reaginic antiserum prepared in rats. 2 The effect of various pharmacological antagonists on anaphylactic bronchoconstriction in vivo were examined. An antihistamine (mepyramine), a kallikrein inactivator (aprotinin) or a prostaglandin synthesis inhibitor (aspirin) did not inhibit PLA, whereas an anti-5-hydroxytryptamine agent (methysergide) and an anti-slow reacting substance-A agent (FPL, 55712) significantly reduced the response. 3 Isolated perfused lungs taken from sensitized rats released, on challenge with the sensitizing antigen, histamine, 5-hydroxytryptamine, slow reacting substance of anaphylaxis (SRS-A) and prostaglandins, but no rabbit aorta contracting substance (RCS). 4 Disodium cromoglycate inhibited both anaphylactic bronchoconstriction in vivo and the anaphylactic release of mediators in vitro. Inhibition in vivo was dose-related. 5 Mediators from the intestine, the primary shock organ of anaphylaxis in the rat, did not contribute to the lung response. 6 Vagal reflex pathways were found not to be important in PLA in vivo. 7 The relationship between the mediators released following antigen challenge of passively sensitized rat lung in vitro and passive lung anaphylaxis in vivo is discussed.

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Section: Discussionsupporting

confidence: 45%

Mediators of Passive Lung Anaphylaxis in the Rat

Farmer¹,

Richards²,

Sheard³

et al. 1975

British J Pharmacology

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“…It is likely, therefore, that SCG reduced the reflex bronchoconstriction to histamine by an action on the afferent arm of the reflex. Mills, Sellick & Widdicombe (1969), Gold, Kessler & Yu (1972) and Sampson & Vidruk (1975) There has been some controversy over the role of the vagus nerves in allergic bronchoconstriction (Gold, 1973). Widdicombe and his colleagues have studied the role of vagally mediated reflexes in the response to systemically administered antigen in guinea-pigs and rabbits.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Sodium Cromoglycate on Histamine Aerosol‐induced Reflex Bronchoconstriction in the Anaesthetized Dog

Jackson¹,

Richards²

1977

British J Pharmacology

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1The effects have been studied of sodium cromoglycate (SCG), given by aerosol or intravenously, on reflex bronchoconstriction induced by histamine aerosol in the anaesthetized dog. 2 Four breaths of an aerosol generated from a 2% solution of SCG significantly inhibited the vagally mediated increase in total lung resistance (RL) produced by histamine. 3 SCG given intravenously as bolus injections (5-500 jg/kg) produced a dose-dependent reversal of a sustained reflex bronchoconstriction induced by histamine aerosol. Propranolol (500 gg/kg) did not prevent this reversal. 4 SCG did not inhibit the increase in RL produced by supramaximal electrical stimulation of a vagus nerve. SThe possibility is discussed that SCG may reduce the activity of lung irritant receptors in the anaesthetized dog.

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“…Gold, et al (13) found that the increase in airflow resistance by Ascaris extract in dogs was blocked by atropine or bilateral cervical vagotomy. We also confirmed the critical importance of the parasympathetic nervous system in antigen-induced bronchoconstriction in sensitized dogs, by the fact that pretreatment of atropine or hexamethonium markedly inhibited the increase in airway resistance produced by Asc-Ag.…”

mentioning

confidence: 99%