The Effects of Sodium Cromoglycate on Histamine Aerosol‐induced Reflex Bronchoconstriction in the Anaesthetized Dog

Jackson, D.M.; Richards, Ivan M.

doi:10.1111/j.1476-5381.1977.tb08413.x

Cited by 51 publications

(32 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histamine, one of the main mediators liberated at an antigen-antibody reaction in guineapigs, is thought to trigger a bronchoconstriction through an 'irritant' receptor, parasympathetic reflex mechanism (for references see Boushey, Holtzman, Sheller & Nadel, 1980). Jackson & Richards (1977), using dogs, demonstrated that SCG inhibits a bronchospasm induced by histamine aerosol but not one induced by electrical stimulation of the vagus nerve. They suggest that SCG reduces the reactivity of the afferent vagal pathway probably by action on the 'irritant' receptors.…”

Section: Discussionmentioning

confidence: 99%

Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Effect of Long‐term Treatment With Sodium Cromoglycate and Aminophylline

Andersson

Bergstrand

1981

British J Pharmacology

View full text Add to dashboard Cite

The effects of long‐term treatment with sodium cromoglycate (SCG) and aminophylline on antigen‐induced bronchoconstriction have been studied in guinea‐pigs actively sensitized according to two different regimens (one producing IgE‐ and IgG‐like antibodies and the other producing exclusively IgG‐like antibodies). Treatment for three weeks with SCG (10 mg/kg) and aminophylline (10,30 or 60 mg/kg) led to a decreased bronchial response capacity which persisted even three days after treatment ceased. In this respect SCG was effective only in guinea‐pigs sensitized to produce at least partly IgE‐like antibodies; aminophylline was effective in guinea‐pigs sensitized to produce both IgE and/or IgG antibodies. The results in vivo with SCG were reflected in vitro by a reduced capacity of chopped lung tissue to release histamine at antigen challenge; lungs from animals treated with aminophylline did not show reduced histamine releasing capacity. Acute treatment with atropine was shown to reduce significantly the antigen‐induced bronchial contraction in guinea‐pigs sensitized to produce both IgE‐ and IgG‐antibodies. No effect of atropine was seen on an IgG‐mediated anaphylaxis. Increased reactivity to methacholine but not to histamine was seen in guinea‐pigs sensitized to produce both IgG‐ and IgE‐antibodies. Long‐term treatment with SCG did not affect this hyperreactivity to methacholine. Decreased reactivity to isoprenaline was found in isolated tracheae taken from guinea‐pigs sensitized to produce both IgE‐ and IgG‐like antibodies compared to unsensitized guinea‐pigs. Long‐term treatment with SCG, but not with aminophylline, reversed this decreased reactivity.

show abstract

Section: Discussionmentioning

confidence: 99%

Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Effect of Long‐term Treatment With Sodium Cromoglycate and Aminophylline

Andersson

Bergstrand

1981

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…) (Amdur & Mead, 1958). The respiratory computer described by Carney, Pugh & Sheard (1972) Jackson & Richards, 1977). Aerosols were generated on inspiration only, using a Vaponefrin inhalajet nebuliser modified to deliver an aerosol containing mainly large particles (12.8 jm).…”

Section: Methods Measurement Of Latencies To Injections Of Sodium Crmentioning

confidence: 99%

“…Cox, Beach, Blair, Clarke, King, Lee, Loveday, Moss, Orr, Ritchie & Sheard (1970) and Jackson & Richards (1977) have also reported that sodium cromoglycate, given intravenously in bolus doses, to the anaesthetized dog produces a reflex hypotension and bradycardia which is mediated via the vagus nerves. The purpose of this study was to elucidate these responses by investigating the nervous receptors involved.…”

Section: Introductionmentioning

confidence: 97%

“…Sodium cromoglycate, a drug used in the treatment of asthma, can reverse reflex bronchoconstriction in the anaesthetized dog, and it has been suggested that this reversal is the result of an action on lung irritant receptors (Jackson & Richards, 1977). Cox, Beach, Blair, Clarke, King, Lee, Loveday, Moss, Orr, Ritchie & Sheard (1970) and Jackson & Richards (1977) have also reported that sodium cromoglycate, given intravenously in bolus doses, to the anaesthetized dog produces a reflex hypotension and bradycardia which is mediated via the vagus nerves.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effects of Sodium Cromoglycate on Lung Irritant Receptors and Left Ventricular Cardiac Receptors in the Anaesthetized Dog

Dixon¹,

Jackson²,

Richards³

1979

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

I The time from the injection of sodium cromoglycate 10 to 50 gg/kg into a saphenous vein, the cervical carotid arteries, the left ventricle and the aortic arch, to the onset of reflex hypotension has been measured in anaesthetized dogs. The shortest latency was 16.9 s on injection of sodium cromoglycate into the left ventricle.2 Instillation of 2% lignocaine into the pericardium of an anaesthetized dog blocked the reflex hypotensive response to sodium cromoglycate (10 to 50 pg/kg i.v.), and also prevented sodium cromoglycate (100 pg/kg) from reversing reflex bronchoconstriction induced by inhalation of an aerosol of histamine.3 The effect of sodium cromoglycate (100 gg/kg i.v.) on resting discharge and histamine-induced discharge (20 pg/kg i.v.) of five lung irritant receptors in five anaesthetized dogs has been studied. Sodium cromoglycate (100 pg/kg i.v.) did not affect the resting discharge of these receptors or their ability to respond to histamine.4 Sodium cromoglycate (100 pg/kg i.v.) increased the rate of discharge of three receptors found in the endocardium of the left ventricle of the canine heart. A solution of sodium cromoglycate (0.1%) was applied topically to one receptor and its rate of discharge was increased. 5 It is suggested that in the dog, sodium cromoglycate produces reflex hypotension and reverses histamine-induced reflex bronchoconstriction by activating receptors in the left ventricle of the heart.

show abstract

“…Both drugs inhibit bronchoconstriction caused by challenges not thought to act by an IgE-dependent release of mast cell mediators, such as exercise (Shaw & Kay, 1985), fog (Robuschi et al, 1986), cold air (Breslin et al, 1980) and sulphur dioxide (SO2) (Harries et al, 1981;Allistone et al, 1985;Dixon et al, 1987). The inhibitory effects of sodium cromoglycate and nedocromil sodium against S02-induced bronchoconstriction suggest that there may be an effect on sensory nerves in the airway and such an effect has been demonstrated experimentally in dogs (Jackson & Richards, 1977).…”

Section: Introductionmentioning

confidence: 99%

Bradykinin‐induced bronchoconstriction: inhibition by nedocromil sodium and sodium cromoglycate.

Dixon

Barnes

1989

Brit J Clinical Pharma

View full text Add to dashboard Cite

1 The effects of inhaled nedocromil sodium and sodium cromoglycate on bradykinininduced bronchoconstriction have been studied in a double-blind, placebo controlled study, in eight mild asthmatic subjects. 2 The subjects attended on four occasions. Fifteen minutes after drug pre-treatment a bradykinin challenge was performed. Increasing concentrations were inhaled until a greater than 40% fall in expiratory flow at 30% of vital capacity from a partial flow volume manoeuvre (Vp30) was demonstrated.3 Inhaled bradykinin (0.06-8.0 mg ml-1) caused dose-related bronchoconstriction with the geometric mean cumulative dose causing a 40% fall in Vp3o (PD40) of 0.035 (95% CI: 0.02-0.07) ,umol, after placebo inhalation, which was similar to that measured before the trial (0.04: 0.02-0.09 ,umol). 4 Both nedocromil sodium (4 mg) and sodium cromoglycate (10 mg) gave significant protection (P < 0.05) against bradykinin-induced bronchoconstriction (PD40 0.37: 0.19-0.72 p,mol after nedocromil sodium and 0.22: 0.11-0.49 after sodium cromoglycate). 5 Since bradykinin-induced bronchoconstriction is probably neurally mediated we conclude that both nedocromil sodium and sodium cromoglycate have an action on neural pathways which may be useful in the control of asthma symptoms.

show abstract

The Effects of Sodium Cromoglycate on Histamine Aerosol‐induced Reflex Bronchoconstriction in the Anaesthetized Dog

Cited by 51 publications

References 11 publications

Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Effect of Long‐term Treatment With Sodium Cromoglycate and Aminophylline

Antigen‐induced Bronchial Anaphylaxis in Actively Sensitized Guinea‐pigs: Effect of Long‐term Treatment With Sodium Cromoglycate and Aminophylline

The Effects of Sodium Cromoglycate on Lung Irritant Receptors and Left Ventricular Cardiac Receptors in the Anaesthetized Dog

Bradykinin‐induced bronchoconstriction: inhibition by nedocromil sodium and sodium cromoglycate.

Contact Info

Product

Resources

About