“…Given that the low dose of risperidone had no effects, our results suggest that the higher dose acted by blocking DA D 2 receptors, although blockade of 5-HT 2 receptors could also have contributed to the effects observed. A recent study in our laboratory has demonstrated that DA D 2 receptors are involved in the rewarding effects of MDMA, since raclopride and haloperidol blocked the development of CPP (Vidal-Infer et al, 2012). Furthermore, a study using mice without 5-HT 2B receptors highlighted the role of said receptors in the rewarding effects induced by low (but not high) doses of MDMA, since 30 (but not 10) mg/kg induced CPP (Doly et al, 2009).…”