Conditioned Place Preference as a Preclinical Model for Screening Pharmacotherapies for Drug Abuse

Bardo, Michael T.; Horton, David B.; Yates, Justin R.

doi:10.1016/b978-0-12-420172-9.00007-2

Cited by 4 publications

(3 citation statements)

References 203 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development and persistence of OUD involves the formation and stability of learned associations between opioids and the context in which they are experienced, and the CPP paradigm offers a useful tool for specifically studying drug-context associations and the variables that modulate their strength and stability (Bardo & Bevins, 2000; Bardo et al ., 2015). As females have been largely omitted from the literature, here we examined the extent to which these factors, including individual context elements, morphine dose, and locomotor effects of morphine, interact to affect morphine-context associations in both sexes.…”

Section: Discussionmentioning

confidence: 99%

Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner

Hámor,

Hartmann,

Garcia

et al. 2023

Preprint

View full text Add to dashboard Cite

Sex differences in opioid use, development of opioid used disorder, and relapse behaviors indicate potential variations in opioid effects between men and women. The locomotor and interoceptive effects of opioids play essential roles in opioid addiction, and uncovering the neural mechanisms underlying these effects remain crucial for developing effective treatments. In this study, we examined the dose-dependent effects of morphine on locomotor sensitization and the strength and stability of morphine-context associations in the conditioned place preference (CPP) paradigm in male and female mice, as well as the relationships between these measures. We observed that while CPP is similar between sexes, the locomotor effects of repeated morphine administration and withdrawal differentially contributed to the strength and stability of morphine-context associations. Specifically, females exhibited higher morphine-induced hyperlocomotion than males regardless of the context in which morphine was experienced. Greater locomotor sensitization to morphine in females than males emerged in a dose-dependent manner only when there was sufficient context information for CPP to be established. Additionally, the relationships between the locomotor effects of morphine and the strength and stability of CPP were different in males and females. In females, positive acute and sensitizing locomotor effects of morphine were correlated with a higher CPP score, while the opposite direction of this relationship was found in males. These results suggest that different aspects of the subjective experience of morphine intoxication and withdrawal are important for morphine abuse-related behaviors and highlight the importance of sex-specific responses in the context of opioid addiction.

show abstract

Section: Discussionmentioning

confidence: 99%

Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner

Hámor,

Hartmann,

Garcia

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…CPP is widely used to study the neurobiological bases of reward ( Tzschentke, 2007 ) and is used to screen potential pharmacotherapies for SUDs ( Bardo et al, 2015 ). Entering the terms “conditioned place preference” OR “place preference” in PubMed, the number of studies published using CPP has increased from one in 1980 ( Phillips and LePiane, 1980 ) to over 250 per year since 2011.…”

Section: Discussionmentioning

confidence: 99%

“…Conditioned place preference (CPP) is used to measure the conditioned rewarding effects of a stimulus, including drugs (see Bardo and Bevins, 2000 ; Tzschentke, 2007 ; Bardo et al, 2015 ; McKendrick and Graziane, 2020 ), social interaction ( Calcagnetti and Schechter, 1992 ; Ma et al, 2006 ; Trezza et al, 2009 ; Yates et al, 2013 ; Pinheiro et al, 2016 ; Cann et al, 2020 ), food ( Duarte et al, 2003 ; Ma et al, 2006 ; Nesbit et al, 2017 ; Jamali et al, 2021 ; Huerta et al, 2022 ), and copulation ( Meerts and Clark, 2007 ; Ismail et al, 2010 ; Guterl et al, 2015 ; Quintana et al, 2019 ). CPP experiments are primarily conducted in an apparatus composed of either two or three compartments that can vary in one or more ways.…”

Section: Introductionmentioning

confidence: 99%

Quantifying conditioned place preference: a review of current analyses and a proposal for a novel approach

Yates

2023

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Conditioned place preference (CPP) is used to measure the conditioned rewarding effects of a stimulus, including food, drugs, and social interaction. Because various analytic approaches can be used to quantify CPP, this can make direct comparisons across studies difficult. Common methods for analyzing CPP involve comparing the time spent in the CS+ compartment (e.g., compartment paired with drug) at posttest to the time spent in the CS+ compartment at pretest or to the CS– compartment (e.g., compartment paired with saline) at posttest. Researchers can analyze the time spent in the compartment(s), or they can calculate a difference score [(CS+post – CS+pre) or (CS+post – CS–post)] or a preference ratio (e.g., CS+post/(CS+post + CS–post)). While each analysis yields results that are, overall, highly correlated, there are situations in which different analyses can lead to discrepant interpretations. The current paper discusses some of the limitations associated with current analytic approaches and proposes a novel method for quantifying CPP, the adjusted CPP score, which can help resolve the limitations associated with current approaches. The adjusted CPP score is applied to both hypothetical and previously published data. Another major topic covered in this paper is methodologies for determining if individual subjects have met criteria for CPP. The paper concludes by highlighting ways in which researchers can increase transparency and replicability in CPP studies.

show abstract

Expression of stable and reliable preference and aversion phenotypes following place conditioning with psychostimulants

et al. 2022

View full text Add to dashboard Cite

Conditioned Place Preference as a Preclinical Model for Screening Pharmacotherapies for Drug Abuse

Cited by 4 publications

References 203 publications

Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner

Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner

Quantifying conditioned place preference: a review of current analyses and a proposal for a novel approach

Expression of stable and reliable preference and aversion phenotypes following place conditioning with psychostimulants

Contact Info

Product

Resources

About