Effects of risperidone on the acquisition and reinstatement of the conditioned place preference induced by MDMA

Roger-Sánchez, C.; Rodrı́guez-Arias, Marta; Miñarro, José; Aguilar, M.A.

doi:10.1016/j.brainresbull.2013.07.009

Cited by 8 publications

(2 citation statements)

References 46 publications

(55 reference statements)

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“…In accordance with our previous studies, MDMA induced CPP and reinstatement after extinction (Daza-Losada et al, 2007;Rodríguez-Arias et al, 2010;Vidal-Infer et al, 2012;Roger-Sánchez et al, 2013a, 2013b, 2013c, indicating that this drug produces long-term alterations that increase the vulnerability of subjects to relapse after abstinence, as occurs with other drugs of abuse. Conversely, memantine did not induce motivational effects, which is also in line with previous studies (Maldonado et al, 2003(Maldonado et al, , 2007Ribeiro Do Couto et al, 2004, 2005Olive et al, 2012).…”

Section: Discussionsupporting

confidence: 89%

“…As these effects seem to depend on the activation of DA and 5-HT receptors (Schenk et al, 2011;Vidal-Infer et al, 2012;Roger-Sánchez et al, 2013b, 2013c, it is possible that memantine decreases the levels of these neurotransmitters. Activation of NMDARs stimulates DA release in rat striatal slices, and memantine inhibits this effect (Nankai et al, 1995).…”

Section: Discussionmentioning

confidence: 97%

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Involvement of NMDA glutamate receptors in the acquisition and reinstatement of the conditioned place preference induced by MDMA

García-Pardo

Escobar-Valero

Rodrı́guez-Arias

et al. 2015

Behavioural Pharmacology

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Some 3,4-methylenedioxymethamphetamine (MDMA) users become dependent as a result of chronic consumption. A greater understanding of the neurobiological basis of the rewarding effects of MDMA could contribute to developing effective pharmacotherapies for MDMA-related problems. The present study evaluated the role of N-methyl-D-aspartate (NMDA) glutamate receptors (NMDARs) in the acquisition and reinstatement of conditioned place preference (CPP) induced by MDMA. Adolescent male mice were conditioned with 1 or 10 mg/kg MDMA and pretreated with 5 or 10 mg/kg of the NMDAR antagonist memantine during acquisition of conditioning (experiment 1), or before a reinstatement test (experiment 2). In addition, the effects of memantine on acquisition of chocolate-induced CPP and the effects of memantine and MDMA on a passive avoidance task were evaluated. Memantine did not exert any motivational effects, but blocked the acquisition of MDMA-induced CPP. Moreover, following acquisition and extinction of MDMA-induced CPP, memantine did not induce reinstatement but blocked reinstatement of the CPP induced by priming with MDMA. Memantine did not block the CPP induced by chocolate, and it partially reversed the impairing effects of MDMA on memory. Our results demonstrate that NMDARs are involved in acquisition of the conditioned rewarding effects of MDMA and in priming-induced reinstatement of CPP following extinction. Moreover, they suggest the validity of memantine for the treatment of MDMA abuse.

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