Role of tachykininergic and cholinergic pathways in modulating canine gastric tone and compliance in vivo

Crema, Francesca; Moro, Elisabetta; Nardelli, G.; Ponti, Fabrizio De; Frigo, Gianmario; Crema, A.

doi:10.1006/phrs.2002.0953

Cited by 14 publications

(10 citation statements)

References 46 publications

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“…testinal transit evoked by evisceration and gut manipulation in a dose-dependent manner. These results are consistent with data showing that NK 1-3 antagonists do not affect peristalsis in guinea pig and dog under normal conditions [14,15], whereas they exert a protective action against the inhibition of gastrointestinal motility invoked by colorectal distension or intestinal manipulation [9,16,17]. In contrast, Herrscher showed that the administered combination of NK 1 receptor and CGRP antagonists abolish the protective activity of each agent given separately to prevent the postoperative gastric motility inhibition [18].…”

Section: Discussionsupporting

confidence: 87%

Salutary Effects of Tachykinin Receptor Antagonists in a Rat Model of Postoperative Ileus

Ciechanownicz

Anand

Chodorowski

et al. 2006

Journal of Surgical Research

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Section: Discussionsupporting

confidence: 87%

Salutary Effects of Tachykinin Receptor Antagonists in a Rat Model of Postoperative Ileus

Ciechanownicz

Anand

Chodorowski

et al. 2006

Journal of Surgical Research

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“…Several observations suggest that there is a tonic cholinergic input to the proximal stomach under normal physiological conditions. For instance, in both dogs and humans, atropine reduced the proximal gastric tone during both fasting and gastric balloon distension [1,26,27]. However, Bruley des Varannes et al [28] did not find any significant effect on fasting or postprandial gastric tone in humans treated with atropine, which is similar to the present result in SD rats.…”

Section: Discussionsupporting

confidence: 81%

Wistar Kyoto rats have impaired gastric accommodation compared to Sprague Dawley rats due to increased gastric vagal cholinergic tone

Nielsen

Bayati

Mattsson

2006

Scandinavian Journal of Gastroenterology

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“…The control of proximal gastric tone is mainly mediated by cholinergic and nitrergic efferent nerves through vagovagal pathways and is based on a balance between the cholinergic contractile and the nitrergic relaxant drive (22)(23)(24). Atropine, as a cholinergic pathway blocker, inhibits the effects of vagal impulses, relaxes the proximal stomach, and reduces fasting proximal gastric tone (25,26). The mechanisms via which rectal distension affects gastric tone are unclear.…”

Section: Discussionmentioning

confidence: 99%

Rectal Distension Modulates Canine Gastric Tone and Accommodation

Lei¹,

Zhu²,

Xing³

et al. 2005

Dig Dis Sci

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Rectal distension affects upper GI myoelectrical activity and motility. The aim of this experiment was to investigate the effect of rectal distension on gastric tone, accommodation, and the underlying mechanism. Seven healthy dogs were surgically prepared and studied. Gastric tone and accommodation were assessed with a barostat. In Experiment 1, the effect of rectal distension on gastric tone and accommodation was evaluated; in Experiment 2, rectal distensions with various volumes were randomly applied and its effects on gastric tone were evaluated; and in Experiment 3, the role of the cholinergic pathway in distension-induced gastric relaxation was assessed. The results showed the following. (1) Rectal distension exerted an inhibitory effect on gastric tone, and this response was distension volume-dependent. (2) Postprandial gastric volume was similar in the control (468.6 +/- 24.7 ml) and the distension study (463.2 +/- 17.5 ml). However, rectal distension increased the preprandial gastric volume, and subsequently decreased the extent of gastric accommodation (139.3 +/- 34.7 ml), which was significantly lower than that of the control (383.2 +/- 26.3 ml; P < 0.001). (3) An intravenous bolus of atropine increased the astric volume from the baseline of 89.4 +/- 12.6 ml to 161.5 +/- 9.8 ml (P < 0.01), and subsequent rectal distension further increased this volume, but the overall change was comparable between the control (297.6 +/- 18.7 ml) and the atropine study (312.1 +/- 21.9 ml; P > 0.05). In conclusion, rectal distension inhibits gastric tone in a volume-dependent manner and impairs gastric accommodation. Atropine dose not block the effect of rectal distension on proximal gastric tone, suggesting that the observed effect may not be mediated by cholinergic pathway.

show abstract

Role of tachykininergic and cholinergic pathways in modulating canine gastric tone and compliance in vivo

Cited by 14 publications

References 46 publications

Salutary Effects of Tachykinin Receptor Antagonists in a Rat Model of Postoperative Ileus

Salutary Effects of Tachykinin Receptor Antagonists in a Rat Model of Postoperative Ileus

Wistar Kyoto rats have impaired gastric accommodation compared to Sprague Dawley rats due to increased gastric vagal cholinergic tone

Rectal Distension Modulates Canine Gastric Tone and Accommodation

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