Role of Surgery in the Treatment of Primary Pulmonary B-Cell Lymphoma

Primary pulmonary lymphoma is a very rare neoplasm that represents only 3-4% of extranodal non-Hodgkin lymphoma (NHL), less than 1% of NHL and only 0.5-1% of primary pulmonary malignancies. Primary pulmonary NHL is most commonly represented by marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma). The clinical characteristics, methods of treatment, and outcomes are not well-elucidated. We, therefore, reviewed the medical records of five Moroccan patients who were pathologically and clinically diagnosed as primary pulmonary lymphoma and treated in our institute of oncology.

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“…But in the absence of comparative series, the efficacy of these treatments cannot be analyzed. [789]…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary lymphoma: About five cases and literature review

et al. 2014

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“…Differentiation between Waldenstrom’s macroglobulinaemia and BALT lymphoma can be difficult as there are several similarities. In up to one quarter of patients with non-gastrointestinal primary sites of MALT lymphomas, disseminated disease is present in the form of infiltration into non-mucosal sites such as bone marrow or multiple mucosal sites 8. A third of the patients with MALT/marginal zone B cell lymphoma demonstrate plasma cell differentiation and a serum M protein band.…”

Section: Discussionmentioning

confidence: 99%

Bronchial associated lymphoid tissue (BALT) lymphoma presenting as chronic lung sepsis

et al. 2009

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A 58-year-old woman was referred from her general practitioner to the respiratory clinic with a 2 year history of recurrent pulmonary infections, mucus hypersecretion and right lobe consolidation following a severe pneumonic illness in 2006. She had no significant risk factors for respiratory disease. Chest computed tomography showed an air bronchogram and right lower lobe consolidation. On initial routine investigation IgA and IgG were normal; however, a discrete IgM paraprotein band in the mid gamma region was seen on serum electrophoresis. She was referred for haematological investigations. Bone marrow biopsy was positive for monoclonal lymphoplasmocytoid B cells and the patient was diagnosed with Waldenström's macroglobulinaemia. Due to recurrent infections and an unclear diagnosis of the lung process, a right lower lobectomy and wedge resection of the middle lobe was performed. This showed bronchial associated lymphoid tissue lymphoma arising in the marginal zone. She has been well since surgery with no further respiratory infections.

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“…3) A commonly used set of criteria for PPL proposed by L'Hoste and associates is lymphoma with involvement of the lung, lober, or primary bronchus, with or without mediastinal involvement, and no evidence of extrathoracic lymphoma at the time of diagnosis or for 3 months thereafter. 4,5) The most common PPL type is mucosa-associated lymphoid tissue (MALT) lymphoma, an extranodal marginal zone lymphoma that accounts for 80%-90% of PPL cases. DLBCL is the second most common type of PPL, and both MALT lymphoma and DLBCL are non-Hodgkin lymphomas.…”

Section: Discussionmentioning

confidence: 99%