Primary pulmonary lymphoma: About five cases and literature review

Majid, Noura; Kamal, El Bakraoui; Oncology, Boukir; Aassab, Rachid; Hassan, Inrhaoun Hannane Errihani

doi:10.4103/0970-2113.125909

Cited by 15 publications

(9 citation statements)

References 11 publications

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“…Consistent with previous studies, 10,11,19,19,20 pulmonary MALToma had a favorable prognosis with a 5‐year estimated overall survival rate of 100.0%. In addition, 23 patients who underwent serial CT examinations had no change of extent of parenchymal lesions during follow‐up before pathological diagnosis, which indicated an indolent nature of pulmonary MALToma.…”

Section: Discussionsupporting

confidence: 89%

“…Unlike other primary pulmonary lymphoma subtypes, pulmonary MALToma is often incidentally discovered in approximately half of the patients utilizing radiography and shows an indolent clinical course for a long time 4–7 . In addition, pulmonary MALToma has been described to have a favorable prognosis with a 5‐year survival rate of >80% in previous studies 8–10 . Consequently, differentiating pulmonary MALToma from other pulmonary lesions is essential for the treatment of patients.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary mucosa‐associated lymphoid tissue lymphoma: CT findings and pathological basis

Zhao

et al. 2021

Journal of Surgical Oncology

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Background Pulmonary mucosa‐associated lymphoid tissue lymphoma (MALToma) is the most frequent subset of primary pulmonary lymphoma. This study aimed to identify radiologic characteristics of pulmonary MALToma based on computed tomography (CT) observations and pathologic features, and further investigate its prognosis. Methods Sixty‐six patients (55.4 ± 10.9 years; 51.5% male) diagnosed as pulmonary MALToma by pathology were retrospectively enrolled. According to distributions and features of lesions shown on CT, patients were divided into three patterns, including single nodular/mass, multiple nodular/mass, and pneumonia‐like consolidative. Results Variety of the location and extent of the lymphomatous infiltration accounted for different characteristics demonstrated at CT. The pneumonia‐like consolidative pattern was the most frequent pattern observed in 42 patients (63.6%), followed by single nodular/mass (21.2%) and multiple nodular/mass (15.2%). CT features included air bronchogram (72.7%), well‐marginated halo sign (53.0%), coarse spiculate with different lengths (72.7%), angiogram sign (77.1% of 35 patients), peribronchovascular thickening (48.5%), irregular cavitation (16.7%) and pulmonary cyst (7.6%). The estimated 5‐year cumulative overall survival rate of pulmonary MALToma was 100.0%. Conclusions Pulmonary MALToma demonstrates several characteristics at CT. Identification of the significant pulmonary abnormalities of this indolent disease entity might be helpful for early diagnosis and optimal treatment.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Pulmonary mucosa‐associated lymphoid tissue lymphoma: CT findings and pathological basis

Zhao

et al. 2021

Journal of Surgical Oncology

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“…To our knowledge, CT is a very convenient and sensitive method for diagnosing lung lesions. However, PPL manifests itself in many different ways (21,(27)(28)(29)(30)(31), which makes it difficult to be distinguished from lung cancer, pneumonia, tuberculosis, diffuse interstitial lung disease, in our study, especially from lung cancer. In the DLBCL group, 6 out of the 7 cases are mass type, and they were misdiagnosed as lung cancer until pathologically confirmed.…”

Section: Discussionmentioning

confidence: 74%

A retrospective study on the clinical characteristics and radiological features of primary pulmonary lymphoma

Xie¹,

Zhang²,

Wu³

et al. 2020

Transl Cancer Res TCR

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Background: The retrospective study was mainly performed to determine the clinical symptoms and radiological characteristics of primary pulmonary lymphoma (PPL) to improve the recognition and diagnosis of the disease.Methods: Between June 2007 and June 2019, the clinical data and radiological images of the 16 patients with PPL confirmed by pathology were retrospectively analyzed.Results: Among the 16 patients with PPL (6 males and 10 females, aged 32 to 72 years, with a median age of 55.13 years), 9 patients were mucosa-associated lymphoid tissue lymphoma (MALT) and 7 patients were diffuse large B-cell lymphoma (DLBCL); all of the patients did not suffer from autoimmune disease [such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or Sjogren's syndrome (SSS)]; and 11 patients had a long-term smoking history from 10 to 40 years. The common clinical symptoms were as follows: chest discomfort (n=8), cough (n=10), chest pain (n=7), fever (n=6), apnea (n=1), fatigue (n=4) and weight loss (n=3), however, 6 cases did not show clear symptoms at the time of diagnosis. Blood tests revealed anemia (n=6), thrombocytopenia (n=2), lactate dehydrogenase (LDH) level (n=7), C-reactive protein (CRP) (n=9), erythrocyte sedimentation rate (ESR) (n=8) and no tumor-related indexes were detected abnormal.The chest radiological images showed a total of 8 cases with multiple masses, 2 cases with different types of nodes, 4 cases with patchy infiltration or consolidation shadow, with or without an air bronchogram, and 2 cases with a mixed manifestation. All the lesions were only involved in unilateral lung (13 right, 3 left), none of them located on bilateral lung fields. At the time of admission, the patients were misdiagnosed as lung cancer (n=9), pneumonia (n=5), tuberculosis (n=1), and diffuse interstitial lung disease (n=1). Then final pathological diagnosis was confirmed by surgery (n=9), percutaneous lung biopsy (n=5), and bronchoscopic biopsy (n=2).Conclusions: PPL is a rare disease, though clinical symptoms and radiological characteristics are not typical, they serve as significant clues for the diagnosis and differential diagnosis. Accurate diagnosis mainly depends on histopathological examination, however, conducting a retrospectively study could improve and enrich our knowledge to the disease and reduce inappropriate treatments.

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“…Primary lung lymphoma (PLL) is a rare unilateral or bilateral lung disorder defined as clonal lymphoid proliferation affecting one or both lungs (parenchyma and/or bronchi) in a patient with no detectable extrapulmonary involvement at diagnosis or during the subsequent 3 months [4]. PLL is most frequently a MALT lymphoma: a type of extranodal low-grade B-cell lymphoma characterized by proliferation of clonal marginal zone lymphocytes, which is most traditionally associated with Helicobacter Pylori found in the gastrointestinal tract, specifically the stomach [5].…”

Section: Discussionmentioning

confidence: 99%

Primary Pulmonary MALT Lymphoma Presenting as Non-Resolving Pneumonia

Iftikhar

Magh

Cheema

et al. 2017

Advances in Respiratory Medicine

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Primary lung lymphoma (PLL) is a rare unilateral or bilateral lung disorder that is challenging to diagnose solely based on clinical and radiological presentation. PLL may be misdiagnosed as pneumonia or a lung tumor due to non-specific findings. PLL is most frequently a mucosa-associated lymphoid tissue (MALT) lymphoma, a type of extranodal low-grade B-cell lymphoma most commonly discovered in the gastrointestinal tract. PLL should be considered in the differential diagnosis of non-resolving pneumonias. Herein we present a case of an 84-year-old patient discovered to have a primary pulmonary MALT lymphoma presenting as a non-resolving pneumonia causing a clinical challenge.

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Primary pulmonary lymphoma: About five cases and literature review

Cited by 15 publications

References 11 publications

Pulmonary mucosa‐associated lymphoid tissue lymphoma: CT findings and pathological basis

Pulmonary mucosa‐associated lymphoid tissue lymphoma: CT findings and pathological basis

A retrospective study on the clinical characteristics and radiological features of primary pulmonary lymphoma

Primary Pulmonary MALT Lymphoma Presenting as Non-Resolving Pneumonia

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