A Case of Primary Pulmonary Diffuse Large B-Cell Lymphoma Diagnosed by Transbronchial Biopsy

Yoshino, Naoyuki; Hirata, Tomomi; Takeuchi, Chie; Usuda, Jitsuo; Hosone, Masaru

doi:10.5761/atcs.cr.14-00298

Cited by 11 publications

(15 citation statements)

References 9 publications

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“…Primary pulmonary lymphoma is defined as lymphoma with involvement of the lung, lobar, or primary bronchus, with or without mediastinal involvement, and no evidence of extrathoracic lymphoma at the time of diagnosis or for 3 months thereafter [4]. It is an extremely rare neoplasm, accounting for 0.5% of all primary pulmonary malignancies [5], 3–4% of extranodal non-Hodgkin lymphoma, and less than 1% of non-Hodgkin’s lymphoma [6].…”

Section: Discussionmentioning

confidence: 99%

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report

Ding

Makino

Koezuka

et al. 2017

J Cardiothorac Surg

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BackgroundPrimary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is a low-grade B cell lymphoma that is a type of non-Hodgkin lymphoma and a type of primary pulmonary malignant lymphoma. MALT lymphomas affecting the lung show various findings on chest computed tomography, which range from typical nodules or areas of consolidation to findings that are extremely rare in pulmonary MALT lymphomas, such as pure ground-glass opacities throughout the lung.Case presentationA 35-year-old woman was found to have a few shadows with ground glass opacities on chest computed tomography (CT) in 2012. A shadow in right S10 that was initially very small increased in size over time, and was 14 × 8 mm in 2015. Other shadows also appeared. Because lung adenocarcinoma was suspected, the patient underwent video-assisted thoracoscopic surgery with a right wedge resection of the lower lobe that included the largest nodule in S10 and other nodules. Histopathological examination of the right S10 and other lesions revealed small- or medium-sized lymphocyte-like cells that were located in the alveolar interseptal spaces. The alveolar walls remained intact. Immunohistochemical staining showed that tumor cells were positive for CD20, CD79a, and BCL2 expression. The lesions were diagnosed as extranodal marginal zone B-cell lymphoma of MALT.ConclusionsWe think that the ground glass opacities on CT were accounted for by MALT lesions that contained intact alveolar air spaces. The patient has remained well during 12 months of follow up after surgery. Although she did not receive chemotherapy because the MALT lymphoma lesions have been stable without progression, the patient is kept under close observation because of potential progression of the disease.

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Section: Discussionmentioning

confidence: 99%

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report

Ding

Makino

Koezuka

et al. 2017

J Cardiothorac Surg

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“…Primary pulmonary lymphomas are extremely rare and represent <1% of primary malignant lung tumors, <1% of lymphomas, and only 3%-4% of extranodal lymphomas [6] PPL is defi ned as clonal lymphoid proliferation affecting one or both lungs [7], lobes or primary bronchus, with or without mediastinal involvement, and no evidence of extrathoracic lymphoma at the time of diagnosis or for 3 months thereafter. is a localized alveolar opacity [6], less than 5 cm-diameter and blurred or well-defi ned contours (according to the series); PPL is associated in nearly 50% of cases with an air bronchogram [6], peribronchial disease with a halo of ground-glass shadowing and proximal bronchiectasis.…”

Section: Discussionmentioning

confidence: 99%

“…PPL has low FDG involvement, so the benefi t of FDG-PET in the clinical assessment of this kind of lymphoma is still unclear [6].…”

Section: Discussionmentioning

confidence: 99%

“…Although there is no consensus on the treatment of PPL, surgical resection is generally performed in cases of localized tumors. Because the rate of local recurrence after complete resection is reported to be high, chemotherapy or radiation therapy should be considered for non-indolent lymphomas [6].…”

Section: The Positive Value Of Open Thoracotomy Biopsy Is High Butmentioning

confidence: 99%

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Follicular B-Cell Lymphoma Embedded in a Pulmonary Chondroid Hamartoma: A Case Report

Kovalchuk¹,

Puccini²,

Benelli³

et al. 2017

Arch Hematol Case Rep Rev

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Background: Here we report a rare case of concomitant pulmonary chondroid hamartoma and follicular non Hodgkin lymphoma in a 65-year-old woman with a history of 4-month nonspecifi c symptoms like fever, sweating and weight loss. Methods: Chest CT scan revealed a 12-mm nodule with relatively regular margins in the right middle lung fi eld, adhering to the chest wall, with no involvement of hilar or mediastinal lymph nodes. The patient underwent thoracoscopy and resection of the lesion. Following histological exam and immunohistochemical staining, the patient was diagnosed as having follicular b-cell lymphoma embedded in a pulmonary chondroid hamartoma. FISH analysis was performed and showed the presence of typical follicular lymphoma chromosomal translocation t (14;18) (q32;q21). Conclusions: Following the fi nal diagnosis, we decided not to refer the patient to chemotherapy and she enter watch and wait regimen with imaging control every 6 months. After 18 months, the chest X-ray and abdominal ultrasound are still negative with no evidence of recurrence.

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“…Bu hastalardan 5 tanesine interstisyel akciğer hastalığı ön tanısı konularak kesin tanı amaçlı 3 lob biyopsi, bir tanesine de kosta lateral duvarında 3-4. kaburga hizasında tümöral lezyonun eksizyonu ile histopatolojik tanı konulmuştur.Hastalığın altın standard tedavi modalitesi kemoterapidir. Hastaların uzun süreli takibe alınması gereklidir çünkü yıllar sonra bile nüks olabilmektedir(6). Çalışmamızdaki hastanın biri 8 diğeri ise 5 kür R-CHOP rejimini içeren kemoterapi aldı.…”

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Akciğerin Nadir Tümörleri; 74 Olgu

Keskin¹,

Ergin²,

Dertsiz³

et al. 2018

Akd Med J

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Bu çalışmada, akciğerin nadir görülen tümörlerinin birlikte değerlendirilmesi amaçlandı. Böylelikle olgu sunumları şeklinde literatürde yer alan bu olgular tek bir yazı altında toplanmaya çalışıldı. Gereç ve Yöntemler: Bu geriye dönük çalışmaya kliniğimizde Ocak 2010 ile Aralık 2017 tarihleri arasında opere edilen 6879 hasta dahil edildi. Histolojik sınıflamada, görülme sıklığı %5ʼden az olan tümörler nadir tümör olarak kabul edildi. Akciğerin nadir tümörü tanısı alan 74 olgu alt gruplara ayrılarak incelendi. Bulgular: Çalışmadaki 74 hastanın yaş ortalaması 54,5'dir. Hastaların 12 tanesi kadın 62 tanesi erkekti. Tümörlet tanısı alan olguların, %83,3'ü kadın iken büyük hücreli nöroendokrin tümör tanısı alan olguların %100'ü erkekti. Araştırmaya dâhil edilen 74 hastanın 18 tanesi eksitus olurken, 56 tanesinin takip ve tedavileri devam etmektedir. Sonuç: Akciğerin nadir tümörleri literatürde genellikle olgu sunumları şeklinde bulunmaktadır ve kesinleşmiş bir tedavi protokolleri yoktur. Bu tümörlerin daha iyi anlaşılabilmesi için geniş hasta serilerine ihtiyaç vardır.

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A Case of Primary Pulmonary Diffuse Large B-Cell Lymphoma Diagnosed by Transbronchial Biopsy

Cited by 11 publications

References 9 publications

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report

Primary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with multiple pure ground-glass opacities: a case report

Follicular B-Cell Lymphoma Embedded in a Pulmonary Chondroid Hamartoma: A Case Report

Akciğerin Nadir Tümörleri; 74 Olgu

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