Role of some Egyptian medicinal plants against liver and kidney toxicity induced by cadmium chloride

Abstract

The present study was designed to evaluate the protective effect of some local medicinal plants against liver and kidney toxicity induced by cadmium chloride. Methanolic extracts of Acacia nilotica and Retama raetam were used in this study. Furthermore, histopathological and histochemical investigations were done. Cadmium chloride caused a significant increase in serum AST, ALT, ALP, bilirubin, urea, and creatinine, cholesterol, LDL, triglycerides, and HDL levels Administration of Acacia nilotica and Retama raetma significantly inhibit that increase. Cadmium chloride induced a significant decrease in serum total protein, albumin, globulin levels, albumin/globulin ratio, blood SOD, and GPx, while Acacia nilotica and Retama raetam increase. Cadmium chloride caused a significant increase in MDA and NO, while a significant decrease in MDA and NO after Acacia nilotica and Retama raetam administration. These results suggested a beneficial effect of these plant extracts against experimentally-induced hepato- and nephro-toxicity of cadmium, and the possible mechanism of the protective effects may be partly due to the antioxidant activity of these plants.

Assessment of acute and subacute toxic effects of the Saudi folk herb Retama raetam in rats

“…These findings suggest that subacute ingestion of RR-methanolic extract at relatively high doses is nephrotoxic in rats. This is in contrast with previous studies that suggested the ability of the methanolic extract of the powder of the dried seeds of RR to protect against gentamicin-induced nephrotoxicity 34 and cadmium chloride-induced hepato-and nephrotoxicities 15 in rats. The apparent differences can be explained on the basis of the differences in method of extraction, the dosing regimen, as well as the differences in the part used, and environment of RR which might affect the presence and/or concentration of the active constituents.…”

Capillary electrophoretic separation of serum proteins of workers occupationally exposed to heavy metals

“…According to Bossuyt et al [37], an additional peak in the α 2 -globulins fraction may be the result of an excessive concentration of triglycerides in the serum. Koriem et al [38] observed a significant increase in the concentration of cholesterol, low-density lipoproteins and triglycerides in the blood serum of rats exposed to Cd. In these studies, changes identified in the α 2 -globulins fraction may result from the effect of Cd on the protein profile.…”

„Azon orvosságok kezdete, melyeket a májra adnak”

“…Mivel a kadmium legfőképpen a májban és a vesében akkumulálódik, ezért fontos szemügyre venni a receptekben szereplő Acacia nilotica L., nílusi akácia (Mimosaceae) pozitív hatásait a kadmiummérgezés tüneteinek enyhítésében. A nílusi akáciában található egyes flavonoidok (kromonszármazékok) képesek arra, hogy két vagy három vegyér-tékű fémionokkal (Cd 2+ ) fémkomplexet képezzenek, így mérsékeljék az akkumulálódott fémek szabadgyökös reakcióit [19]. Ez a jelenség is indokolja, hogy az akácia helyet kapjon a májjal kapcsolatos receptekben.…”