Assessment of acute and subacute toxic effects of the Saudi folk herb Retama raetam in rats

Algandaby, Mardi M.

doi:10.1016/j.jcma.2015.06.011

Cited by 14 publications

(4 citation statements)

References 30 publications

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“…In this regard, previous pharmacological studies confirmed the lethal effect of the pulp extract of C. colocynthis received by rabbits [42] and also its toxicity on liver cells which may engender hepatocyte necrosis and liver fibrosis [43]. Likewise, the findings of Algandaby [44] revealed that the repeated administration of excessive doses of methanolic extract of R. raetam in rats could exhibit hepatotoxic, nephrotoxic, and mutagenic effects.…”

Section: Toxicity Of Used Plantsmentioning

confidence: 78%

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Karous

Jilani

Ghrabi-Gammar

2021

Plants

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Thanks to its geographic location between two bioclimatic belts (arid and Saharan) and the ancestral nomadic roots of its inhabitants, the sector of Ouled Dabbeb (Southern Tunisia) represents a rich source of plant biodiversity and wide ranging of ethnobotanical knowledge. This work aims to (1) explore and compile the unique diversity of floristic and ethnobotanical information on different folk use of plants in this sector and (2) provide a novel insight into the degree of knowledge transmission between the current population and their semi-nomadic forefathers. Ethnobotanical interviews and vegetation inventories were undertaken during 2014–2019. Thirty informants aged from 27 to 84 were interviewed. The ethnobotanical study revealed that the local community of Ouled Dabbeb perceived the use of 70 plant species belonging to 59 genera from 31 families for therapeutic (83%), food (49%), domestic (15%), ethnoveterinary (12%), cosmetic (5%), and ritual purposes (3%). Moreover, they were knowledgeable about the toxicity of eight taxa. Nearly 73% of reported ethnospecies were freely gathered from the wild. The most commonly used plant parts were leaves (41%) followed by flowers and inflorescence (16%). We reported the use and collection of non-renewable parts (underground storage organs and roots) for 20 ethnospecies. Interestingly, a comparison with the available literature in Tunisia and neighboring countries reveals 13 new useful plants as well as 17 plants with new uses and demonstrates an important reservoir of traditional ethnobotanical heritage that is still sustained by respondents stemming from the semi-nomadic lifestyle of their ancestors (74% of cited taxa). These data could set a basis for further phytochemical and pharmacological research and conservative approach of the most relevant plant species including endemic overused and endangered taxa.

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Section: Toxicity Of Used Plantsmentioning

confidence: 78%

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Karous

Jilani

Ghrabi-Gammar

2021

Plants

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“…This finding contrasts with the results reported by Naik and Sellappan (2019), who observed the absence of phenolics and flavonoids in the root, leaf, bark, and rind of A. muricata extracted with ether by maceration. Algandaby (2015) and Azwinda (2015) highlighted that the presence or absence of phytochemicals depends on various factors, including the test method, solvent, particle size, moisture content, solvent-to-sample ratio, pH, temperature, length of extraction, extraction method, plant part, and origin/ environment. This investigation reports an appreciable level of steroids (+++), resins (+++), and terpenoids (+++) in the extract obtained from A. muricata seeds.…”

Section: Preliminary Screening Of the Phytochemical Constituents Of P...mentioning

confidence: 99%

Storage and time course effects on the quality of oil extracted from Phyllanthus amarus Schumach and Annona muricata Linn and their antidiabetic potentials

Ogunjinmi,

Oriyomi,

Olaogun

et al. 2024

bta

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With the advent of modern technology, advancements in processing and storage techniques, and increasing medical knowledge, people are becoming aware of deterioration in the quality of medicinal products due to storage methods and time. In most cases, herbal products are not consumed immediately after production; as such, improper storage can result in physical, chemical, and microbiological changes. The study evaluated the effect of storage methods and time on the quality of oil extracted from Phyllanthus amarus Schumach and Annona muricata Linn and assessed their antidiabetic and antioxidative effects. Plants were air-dried, pulverized, and then subjected to Soxhlet extraction in petroleum ether. The oil was evaluated for phytochemical constituents and the effects of time and storage methods on its physicochemical properties. Characterization of the oil was done by spectroscopic techniques. Oils from both plants contained tannins, flavonoids, alkaloids, steroids, glycosides, terpenoids, phlobotannins, resins, reducing sugar, phenols, and saponins in different proportions. The oil from A. muricata had higher phenolic (3.11 ± 0.31 mg GAE/g), flavonoid (11.82 ± 0.08 mg QUE/g), alkaloid (16.37 ± 0.56 mg APE/g), and tannin (7.13 ± 0.47 mg CE/g) contents than the oil from P. amarus , which had 0.54 ± 0.08 mg GAE/g, 7.83 ± 0.13 mg QUE/g, 9.87 ± 0.15 mg APE, and 3.16 ± 0.12 mg CE/g for total phenolic, flavonoids, alkaloids, and tannins, respectively. Initial acid, iodine, peroxide, and saponification values recorded for P. amarus were 5.63 ± 0.82 mg KOH/g, 97.17 ±0.53 Wijis, 9.31 ± 0.15 mEq/kg, and 116.11 ± 0.74 mg KOH/g, respectively, significantly different from those of A. muricata , which had values of 1.17 ± 0.08 mg KOH, 76.23 ± 0.03 Wijis, 6.75 ± 0.47 mEq/kg, and 193.31 ± 0.52 mg KOH/g, respectively. FT-IR characterization of the oils revealed the presence of carboxylic acid, alkyl, alkene, alkane, haloalkane, aldehyde, aromatic amine, α-unsaturated and β-unsaturated esters, and phenol functional groups. P. amarus oil inhibited α-amylase (IC 50 0.17 ± 0.03 mg/ml), α-glucosidase (IC 50 0.64 ± 0.03 mg/ml), and xanthine oxidase (0.70 ± 0.01 mg/ml) to a greater extent than A. muricata oil, with IC 50 values of 0.43 ± 0.05 mg/ml (α-amylase), 2.25 ± 0.31 mg/ml (α-glucosidase), and 0.78 ± 0.07 mg/ml (xanthine oxidase). This study showed that oils from the tested plants have low rancidity with a moderate shelf life. The extracts contained essential phytoconstituents that significantly inhibited α-glucosidase and xanthine oxidase. These effects of the oil indicate their potential to prevent diabetes, gout, and oxidative stress. Consequently, the supply of P. amarus and A. muricata in homemade diets is strongly encouraged fo...

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“…Essential oils from flowers indicated antifungal, antibacterial (Edziri et al, 2010;Al-Sharari et al, 2020), antimicrobial and antiseptic activities (Awen et al, 2011;Al-Sharari et al, 2020). Flavonoids α-glucosidase showed inhibitory effect (Ghani et al, 2019;Al-Sharari et al, 2020); antidiabetic activities (Algandaby et al, 2010;Al-Sharari et al, 2020) and minimal nephrotoxic toxicity (Algandaby, 2015;Al-Sharari et al, 2020).…”

Section: Pharmacological Activities Of Retama Sppmentioning

confidence: 99%

A Spotlight on Retama spp., The Mediterranean Evergreen Stem-assimilating Xerophyte

Youssef,

Amer,

Ghaly

et al. 2024

Egypt. J. Bot.

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G ENUS Retama L. (Leguminosae, Tribe Genisteae), is a Mediterranean genus, it naturalized in the new world recently. It includes four (Retama dasycarpa, R. monosperma, R. raetam and R. sphaerocarpa) xeromorphic, stem assimilating species. The associated species to the Retama spp. are variable and controlled by the spatial distribution and geographic location of each species. The pollen grain of Retama spp. is monad, trizono-colporate, some Retama spp. flowers are lacking nectar, others are nectar-producing species and insect pollinated. Retama spp. utilize a combination of defense mechanisms, acclimatization and adaptation strategies including the stress response genes, physiological and microbiological adaptations to both drought and salinity stresses. Soil and endophytic microbes play an important role in improving establishment of Retama species under environmental stresses. Genus Retama is eutetraploid with homogeneous karyologic chromosomes, the genome size is an adaptive trait correlated to environmental situations. This review covered the taxonomy of Retama species and their potentialities in arid lands particularly for their role in soil protection, stability, fertility, and desert rehabilitation. The phytochemistry of Retama species including flavonoids, essential oil, alkaloids, terpenes, steroids, fatty acids, polysaccharides, and mineral composition was elaborated. In addition to its multipurpose uses as fodder, ethnobotanical uses, and pharmacological activities its active compound possess anticancer, antioxidant, hypoglycemic, anti-inflammatory, analgesic, antileukemic, antiarrhythmic, antibacterial, antifungal activities, and others. This study aimed to highlight the potentialities of the C3 shrubby-leguminous species and its adaptive strategies to the arid-desert stresses, to offer interesting trends to improve the economic crops.

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Assessment of acute and subacute toxic effects of the Saudi folk herb Retama raetam in rats

Abstract: Repeated administration of methanolic extract of RR (250 mg/kg) has a low nephrotoxic subacute toxicity potential, while it might have hepatotoxic, nephrotoxic, and mutagenic effects at higher doses.

Cited by 14 publications

References 30 publications

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Storage and time course effects on the quality of oil extracted from Phyllanthus amarus Schumach and Annona muricata Linn and their antidiabetic potentials

A Spotlight on Retama spp., The Mediterranean Evergreen Stem-assimilating Xerophyte

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