Role of silver nanoparticles (AgNPs) on the cardiovascular system

González, Carmen; Rosas-Hernández, Héctor; Ramirez-Lee, Manuel Alejandro; Salazar-García, Samuel; Ali, Syed F.

doi:10.1007/s00204-014-1447-8

Cited by 59 publications

(39 citation statements)

References 87 publications

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“…AgNPs have been employed in the treatment of cardiovascular diseases, neurodegenerative diseases, brain inflammation, neurotoxicity and diabetes etc. [3][4][5]. AgNPs have been widely used as antifilarial, antiinsecticidal, antilarvicidal, antiprotozoal and anticandidal agents [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Eco-friendly synthesis of silver nanoparticles using leaf extract of Flemingia wightiana: spectral characterization, antioxidant and anticancer activity studies

et al. 2020

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In the present investigation, we report simple, robust and eco-friendly synthesis of silver nanoparticles (AgNPs) using leaf extract of Flemingia wightiana. The leaf extract of F. wightiana acts as reducing agent which reduces the silver ions into FW-AgNPs, as well as stabilizing agent by capping around them. Biosynthesized FW-AgNPs were characterized by different spectroscopic techniques. UV-Vis spectrum showed the characteristic SPR peak between 380 and 460 nm. EDX analysis revealed the presence of metallic silver at 3 keV. XRD analysis clearly revealed that FW-AgNPs are crystalline in nature with FCC structure. TEM analysis depicted the spherical morphology with 20-40 nm in size. DLS analysis showed that average hydrodynamic size and PDI value of FW-AgNPs were found to be 47.6 nm and 4.5 respectively. Biosynthesized FW-AgNPs showed high negative zeta potential value of − 25.3 mV. FTIR analysis revealed the participation of polyphenols and proteins in the bioreduction and stabilization of FW-AgNPs. FW-AgNPs showed strong DPPH and H 2 O 2 scavenging activity with IC50 values of 71.96 and 80.59 µg/mL respectively. Further FW-AgNPs also showed effective cytotoxicity against cancer cells including SKOV3 and COLO205 with maximum inhibition of 83.2% and 75.9% respectively.

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Section: Introductionmentioning

confidence: 99%

“…2 Biology and Toxicology Division, CSIR-IICT, Hyderabad, Telangana, India. 3 Department of Chemistry, Yogivemana University, Kadapa, Andhra Pradesh, India. 4 DST-PURSE Center, Sri Venkateswara University, Tirupati, Andhra Pradesh, India.…”

Section: Introductionmentioning

confidence: 99%

Eco-friendly synthesis of silver nanoparticles using leaf extract of Flemingia wightiana: spectral characterization, antioxidant and anticancer activity studies

et al. 2020

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“…The ENMs can enter the body through various ways, e.g., inhalation, ingestion, skin uptake, injection, implantation, and direct penetration in cells and tissues ( Figure 1) [17]. Among these, inhalation and injection are the most common ways of exposure.…”

Section: The Exposure Routes Of Enms and Their Distribution In The Kimentioning

confidence: 99%

Mechanistic Understanding of the Engineered Nanomaterial-Induced Toxicity on Kidney

Zhao

Zhan

et al. 2019

Journal of Nanomaterials

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With the rapid development of nanotechnology, engineered nanomaterials (ENMs) have been applied in many fields, such as food industry, biomedicine, and so on. However, the study on the health and safety implications of ENMs is still insufficient. Previous studies have shown that nanoparticles under acute or chronic exposure could be transported and accumulated in various organs and tissues, resulting in adverse effects or systemic toxicity. Among these, the kidney is one of the main organs that exposed ENMs will target through different routes. One of the important functions of the kidney is to discharge metabolic wastes and exogenous substances from the blood circulation of the whole body. During ENM exposure, the kidney may become vulnerable to toxicity. Studies have suggested that nanoparticles exposed to the kidney could provoke glomerular swelling, basilar membrane thickening, degeneration, and necrosis of renal tubular cells. These adverse effects of nanoparticles on the kidney may be related to their induced oxidative stress, inflammation, autophagy, DNA damage, and ER stress. This review aims to examine current studies on ENM-induced nephrotoxicity, with the focus on elucidating the potential molecular mechanisms of nanoparticle-induced toxicity on the kidney, which will further facilitate the safer design of ENMs and their applications.

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“…The adverse effects of Ag NPs on the cardiovascular system are still debated [106][107][108]. It is also possible to use different exposure routes to investigate the nano-toxic potentials of Ag NPs on the cardiovascular system [109]. Tang et al (2009) reported that Ag NPs could transit directly to the cardiovascular system and cause adverse effects by accumulating in various organs [110].…”

Section: In Vivo Toxicological Information and Experiments About Silvmentioning

confidence: 99%

Assessment of Nano-toxicity and Safety Profiles of Silver Nanoparticles

Budama‐Kilinc¹,

Çakır-Koç²,

Zorlu³

et al. 2018

Silver Nanoparticles - Fabrication, Characterization and Applications

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Nanotoxicology, which is related with toxic potentials of nanoparticles (NPs) and their adverse effects on living organisms and environment, is a sub-branch of toxicology discipline. Nano-toxicity of NPs depends on their doses, unique chemical, and physical properties. Nowadays, silver (Ag) NPs are used in many consumer and scientific applications such as antimicrobial and pharmaceutical applications, water purification systems, textile industry, and food packaging processes. However, the information that about their nano-toxic potentials is still not complete, and it is considered that several parameters of Ag NPs such as size, shape, surface, and stability affect the toxic potential in different ways. Nano-toxic potentials of Ag NPs were mentioned as in vivo, in vitro, and in silico the studies. In this chapter, it was evaluated the common unique properties of NPs are related with nanotoxicology such as size, surface area and modifications, shape, agglomeration status, and dose. : in vivo, in vitro, in silico, nanoparticles, nano-toxicity, silver within organism, and the mechanisms of the actions. At the same time, this concept involves the isolation of the poisons, the analysis of toxic materials as quantitative and qualitative besides that risk analyses, optimization processes, and treatments of poisons [1]. Keywords

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Role of silver nanoparticles (AgNPs) on the cardiovascular system

Cited by 59 publications

References 87 publications

Eco-friendly synthesis of silver nanoparticles using leaf extract of Flemingia wightiana: spectral characterization, antioxidant and anticancer activity studies

Eco-friendly synthesis of silver nanoparticles using leaf extract of Flemingia wightiana: spectral characterization, antioxidant and anticancer activity studies

Mechanistic Understanding of the Engineered Nanomaterial-Induced Toxicity on Kidney

Assessment of Nano-toxicity and Safety Profiles of Silver Nanoparticles

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