In the present investigation, we report simple, robust and eco-friendly synthesis of silver nanoparticles (AgNPs) using leaf extract of Flemingia wightiana. The leaf extract of F. wightiana acts as reducing agent which reduces the silver ions into FW-AgNPs, as well as stabilizing agent by capping around them. Biosynthesized FW-AgNPs were characterized by different spectroscopic techniques. UV-Vis spectrum showed the characteristic SPR peak between 380 and 460 nm. EDX analysis revealed the presence of metallic silver at 3 keV. XRD analysis clearly revealed that FW-AgNPs are crystalline in nature with FCC structure. TEM analysis depicted the spherical morphology with 20-40 nm in size. DLS analysis showed that average hydrodynamic size and PDI value of FW-AgNPs were found to be 47.6 nm and 4.5 respectively. Biosynthesized FW-AgNPs showed high negative zeta potential value of − 25.3 mV. FTIR analysis revealed the participation of polyphenols and proteins in the bioreduction and stabilization of FW-AgNPs. FW-AgNPs showed strong DPPH and H 2 O 2 scavenging activity with IC50 values of 71.96 and 80.59 µg/mL respectively. Further FW-AgNPs also showed effective cytotoxicity against cancer cells including SKOV3 and COLO205 with maximum inhibition of 83.2% and 75.9% respectively.
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