Role of Serotoninergic System in the Development of Gastrointestinal Diseases

Lychkova, A. E.

doi:10.1007/s10517-009-0471-9

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…First, consistent with prior research, we found a subset of patients with both depressive and gastrointestinal disorders [28][29][30][31]. The autonomic nervous system and serotonergic systems are implicated in gastrointestinal functions: gastric smooth muscle cells express 5-HT1 and 5-HT2 receptors where serotonin induces contractions in the gastric fundus and activity at 5-HT3 receptors caused gastric relaxation and accelerated intestinal transit [32,33]. The common gastrointestinal side effects associated with SSRI antidepressants are illustrative of this relationship, however, so too are reports that ondansetron, a 5-HT3 receptor antagonist, improves depressive symptoms [32,34].…”

Section: Discussionsupporting

confidence: 88%

Associations Between Depression, Anxiety, and Multiple Disease Outcomes: A Phenotype x Phenome-Wide Association Study in Electronic Health Records

Gao

Coombes

Ryu

et al. 2022

Preprint

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Unstructured AbstractAnxiety and depression are frequently comorbid yet phenotypically distinct. This study identifies differences in the clinically observable phenome across a wide variety of physical and mental disorders comparing patients with diagnoses of isolated depression, isolated anxiety, or both. Using electronic health records for 14,994 participants with depression and/or anxiety in the Mayo Clinic Biobank, a phenotype x phenome-wide association study (Phe2WAS) was performed to test for differences between these groups. Additional Phe2WAS were performed restricting analyses to diagnoses occurring before or after a diagnosis of depression or anxiety to determine the temporal sequencing of diagnoses. Compared to isolated anxiety, isolated depression was more strongly associated with obesity (OR=1.61; p=3e-22), sleep apnea (OR=1.71; p=1e-22), type II diabetes (OR=1.74; p=9e-18), and neurological disorders (OR=1.54; p=6e-10); these differences were most pronounced for medical diagnoses made after first depression or anxiety diagnosis. In relation to isolated depression, isolated anxiety was more strongly related to palpitations (OR=1.91; p=2e-25), skin neoplasms (OR=1.61; p=2e-17), cardiac dysrhythmias (OR=1.45; p=2e-12), and degenerative skin conditions (OR=1.41; p=1e-10); these differences were most pronounced for medical diagnoses made before a first depression or anxiety diagnosis. Patients with the comorbid depression and anxiety had stronger associations with other mental health disorders, substance use disorders, sleep problems, and digestive problems relative to those with isolated depression or anxiety. While depression and anxiety are closely related, this study suggests that improving phenotypic characterization within the broad categories of depression and anxiety could improve clinical care and provide future directions for research.

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Section: Discussionsupporting

confidence: 88%

Associations Between Depression, Anxiety, and Multiple Disease Outcomes: A Phenotype x Phenome-Wide Association Study in Electronic Health Records

Gao

Coombes

Ryu

et al. 2022

Preprint

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“…Through these receptors, 5-HT regulates the contractile activity of smooth muscles. Serotonin induces contractions of the smooth-muscle cells of the fundal compartment of the stomach during reaction with 5-HT 2B receptors [18]. During ulcer relapse, we noted significantly raised levels of NA, DA and free 5-HT.…”

Section: Discussionmentioning

confidence: 76%

Evaluation on the Pharmacological Effect of Traditional Chinese Medicine SiJunZiTang on Stress-Induced Peptic Ulcers

Chen

Lee

Lin³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Purpose. To explore the effects of SiJunZiTang (SJZT) on central neurotransmitters and the inhibition of HCl hypersecretion, along with the role of the vagus nerve. From this, the effects of SJZT and its constituent ingredients on inhibiting stress-induced peptic ulcers will be determined. Methods. Methods used to determine SJZT's effectiveness included (1) measuring the antipeptic ulcer effects of varying combinations of the constituents of SJZT; (2) evaluations of monoamine (MA) level in the brain; and (3) measuring the effects of longer-term SJZT treatment. Results. Comparing the control and experimental groups where the rats' vagus nerves were not cut after taking SJZT orally (500 mg/kg and 1000 mg/kg), the volume of enterogastric juice, free HCl and total acidity all reduce dose-dependently. The group administered SJZT at 1000 mg/kg showed significant reductions (P < 0.05). For the experimental groups where the vagus nerves were cut, a comparison with the control group suggests that the group receiving SJZT (500 mg/kg) orally for 21 days demonstrated a cure rate of 34.53%. Conclusion. The results display a correlation between the therapeutic effects of SJZT on stress-induced peptic ulcers and central neurotransmitter levels. Further to this, SJZT can inhibit the hypersecretion of HCl in the stomach, thus inhibiting stress-induced peptic ulcers.

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“…First, consistent with prior research, we found strong associations between depressive and gastrointestinal disorders (Fond et al, 2014; Foster & Neufeld, 2013; Neuendorf, Harding, Stello, Hanes, & Wahbeh, 2016; Taylor & Holscher, 2020). The autonomic nervous system and serotonergic systems are implicated in gastrointestinal functions: gastric smooth muscle cells express 5-HT1 and 5-HT2 receptors where serotonin induces contractions in the gastric fundus and activity at 5-HT3 receptors caused gastric relaxation and accelerated intestinal transit (Kindt & Tack, 2007; Lychkova, 2009). The common gastrointestinal side effects associated with SSRI antidepressants are illustrative of this relationship, however, so too are reports that ondansetron, a 5-HT3 receptor antagonist, improves depressive symptoms (Bétry et al, 2011; Kindt & Tack, 2007).…”

Section: Discussionmentioning

confidence: 99%

Phenotypic distinctions in depression and anxiety: a comparative analysis of comorbid and isolated cases

et al. 2023

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Background Anxiety and depression are frequently comorbid yet phenotypically distinct. This study identifies differences in the clinically observable phenome across a wide variety of physical and mental disorders comparing patients with diagnoses of depression without anxiety, anxiety without depression, or both depression and anxiety. Methods Using electronic health records for 14 994 participants with depression and/or anxiety in the Mayo Clinic Biobank, a phenotype-based phenome-wide association study (Phe2WAS) was performed to test for differences between these groups across a broad range of clinical diagnoses observed in the electronic health record. Additional analyses were performed to determine the temporal sequencing of diagnoses. Results Compared to patients diagnosed only with anxiety, those diagnosed only with depression were more likely to have diagnoses of obesity (OR 1.75; p = 1 × 10−27), sleep apnea (OR 1.71; p = 1 × 10−22), and type II diabetes (OR 1.74; p = 9 × 10−18). Compared to those diagnosed only with depression, those diagnosed only with anxiety were more likely to have diagnoses of palpitations (OR 1.91; p = 2 × 10−25), benign skin neoplasms (OR 1.61; p = 2 × 10−17), and cardiac dysrhythmias (OR 1.45; p = 2 × 10−12). Patients with comorbid depression and anxiety were more likely to have diagnoses of other mental health disorders, substance use disorders, sleep problems, and gastroesophageal reflux relative to isolated depression. Conclusions While depression and anxiety are closely related, this study suggests that phenotypic distinctions exist between depression and anxiety. Improving phenotypic characterization within the broad categories of depression and anxiety could improve the clinical assessment of depression and anxiety.

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Role of Serotoninergic System in the Development of Gastrointestinal Diseases

Abstract: Experimental gastroduodenal ulcer was simulated after pre-injection of serotonin; gastroesophageal reflux disease and duodenogastral reflux were induced. Activation of the serotoninergic system promoted the development of alteration processes in gastroduodenal ulcer.

Cited by 3 publications

References 10 publications

Associations Between Depression, Anxiety, and Multiple Disease Outcomes: A Phenotype x Phenome-Wide Association Study in Electronic Health Records

Associations Between Depression, Anxiety, and Multiple Disease Outcomes: A Phenotype x Phenome-Wide Association Study in Electronic Health Records

Evaluation on the Pharmacological Effect of Traditional Chinese Medicine SiJunZiTang on Stress-Induced Peptic Ulcers

Phenotypic distinctions in depression and anxiety: a comparative analysis of comorbid and isolated cases

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