Evaluation on the Pharmacological Effect of Traditional Chinese Medicine SiJunZiTang on Stress-Induced Peptic Ulcers

Abstract

Purpose. To explore the effects of SiJunZiTang (SJZT) on central neurotransmitters and the inhibition of HCl hypersecretion, along with the role of the vagus nerve. From this, the effects of SJZT and its constituent ingredients on inhibiting stress-induced peptic ulcers will be determined. Methods. Methods used to determine SJZT's effectiveness included (1) measuring the antipeptic ulcer effects of varying combinations of the constituents of SJZT; (2) evaluations of monoamine (MA) level in the brain; and (3) measuring the effects of longer-term SJZT treatment. Results. Comparing the control and experimental groups where the rats' vagus nerves were not cut after taking SJZT orally (500 mg/kg and 1000 mg/kg), the volume of enterogastric juice, free HCl and total acidity all reduce dose-dependently. The group administered SJZT at 1000 mg/kg showed significant reductions (P < 0.05). For the experimental groups where the vagus nerves were cut, a comparison with the control group suggests that the group receiving SJZT (500 mg/kg) orally for 21 days demonstrated a cure rate of 34.53%. Conclusion. The results display a correlation between the therapeutic effects of SJZT on stress-induced peptic ulcers and central neurotransmitter levels. Further to this, SJZT can inhibit the hypersecretion of HCl in the stomach, thus inhibiting stress-induced peptic ulcers.

Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells

“…Sagunja-tang (SGJT), a traditional Chinese remedy, consists of four oriental herbs ( Panax ginseng C. A. Meyer, Poria cocos Wolf, Atractylodes japonica Koidzumi, and Glycyrrhiza uralensis Fischer) and has been used as a medicine to enhance vital energy and tonify the function of spleen and stomach in oriental countries. Therefore, SGJT is used for patients with reduced physical strength, a weakened immune system, and gastrointestinal diseases [ 8 ]. According to recent studies, SGJT exhibits several effects, such as antioxidant, anticancer, and immune stimulatory activity, radioprotective effects, and soothing effects [ 9 – 13 ].…”

Observation of the Expression of Vascular Endothelial Growth Factor and the Potential Effect of Promoting Hair Growth Treated with Chinese Herbal BeauTop

“…The changes in hair growth are as follows: 5.9% slightly improved, 29.4% moderately improved, and 17.6% markedly improved [ 37 ]. This represents that the composition of formula mode is an important meaning for improving the research of treating diseases by integrated syndrome differentiation via the new clinical trial design [ 38 ].…”

“…In traditional Chinese medicine culture, qi (also chi) is an active principle forming part of any living organism. Panax japonicus could offer a sweet flavor and warming property effects, strongly invigorate primordial qi and is the principal herb formula [ 38 ]. Interestingly, a study indicated that Shengfaling Tincture acts to increase blood circulation and hair growth in rats with hair depilation.…”

High–efficiency generation of induced pluripotent stem cells from human foreskin fibroblast cells using the Sagunja-tang herbal formula

“…Atractylenolide III, and liquiritigenin have been shown to exert anti-inflammatory effects [ 22 , 23 ], and glycyrrhizin attenuates stem cells- like phenotypes in papilla cells [ 24 ]. Additionally, SGT-4 is used to treat patients with reduced physical strength, a weakened immune system or gastrointestinal diseases [ 9 ].…”

“…( Ginseng Radix, Glycyrrhizae Radix et Rhizoma, Atractylodis Rhizoma Alba, Poria Sclerotium ) and has been medicinally used in Asian countries to enhance vital energy and tonify spleen and stomach function. SGT-4 is applied to patients with reduced physical strength, weakened immune system, and gastrointestinal diseases [ 9 ]. Recent studies have shown that SGT-4 exhibits several effects, including immune stimulatory activity, a radioprotective effect and a soothing effect [ 10 – 12 ].…”