Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells

Abstract

The present study was conducted to investigate the effect of Sagunja-tang on the lipid related disease in a rat model of menopausal hyperlipidemia and lipid accumulation in methyl-β-cyclodextrin-induced HepG2 cells. In in vivo study using menopausal hyperlipidemia rats, Sagunja-tang reduced retroperitoneal and perirenal fat, serum lipids, atherogenic index, cardiac risk factor, media thickness, and nonalcoholic steatohepatitis score, when compared to menopausal hyperlipidemia control rats. In HepG2 cells, Sagunja-tang significantly decreased the lipid accumulation, total cholesterol levels, and low-density/very-low-density lipoprotein levels. Moreover, Sagunja-tang reversed the methyl-β-cyclodextrin-induced decrease in the protein levels of critical molecule involved in cholesterol synthesis, sterol regulatory element binding protein-2, and low-density lipoprotein receptor and inhibited protein levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase as well as activity. Phosphorylation level of AMP-activated protein kinase was stimulated by Sagunja-tang. These results suggest that Sagunja-tang has effect on inhibiting hepatic lipid accumulation through regulation of cholesterol synthesis and AMPK activity in vitro. These observations support the idea that Sagunja-tang is bioavailable both in vivo and in vitro and could be developed as a preventive and therapeutic agent of hyperlipidemia in postmenopausal females.

Retracted: Sagunja‐Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells

“…The article titled “Sagunja-Tang Improves Lipid Related Disease in a Postmenopausal Rat Model and HepG2 Cells” [ 1 ] has been retracted at the request of the authors as it was found to be similar to the following previously published article: “Palmiwon attenuates hepatic lipid accumulation and hyperlipidemia in a menopausal rat model,” by Hiroe Go, Jin Ah Ryuk, Hye Won Lee, and Byoung Seob Ko, in Menopause: The Journal of The North American Menopause Society: 2015, Volume 22, Issue 8, pp. 872–884.…”