Role of relaxin in diastasis of the pubic symphysis peripartum

Predicting Route of Delivery Using Quantification of Maternal Expulsive Efforts in the Second Stage of Labor

“…6 The mechanism by which multiparous patients require fewer pushing contractions and less second-stage time compared with nulliparous patients likely includes the long-term effects of stretching of the pelvic floor muscles and relaxation of the pelvic bone resulting from prior delivery. 12,13 The number of pushing contractions offers new insights in regard to probabilities of spontaneous vaginal delivery. Our data suggest that, by 40 pushing contractions in nulliparous patients and 20 pushing contractions in multiparous patients, 90% of spontaneous vaginal deliveries have occurred.…”

Effects of swimming exercise and RLN2 induction on relaxin levels, MMP-13, TGFβ expression in the pubic cartilage of pregnant rats

“…The relaxin hormone physiologically increases in pregnancy involved in the widening process of the pubic symphysis to facilitate a safe delivery process in many species, including mice and humans (Pinheiro et al, 2004). The higher levels of relaxin in pregnant women provide a more substantial anti-fibrotic effect, which would cause ligament relaxation and damage, including interpubic (Wang et al, 2021). This study attempted to investigate the induction of RLN2 in pregnant rats, increasing relaxin plasma levels, and its correlation to MMP-13 expression in the pubic symphysis cartilage.…”

“…Relaxin produced by the corpus luteum and placenta has an essential role in dilating the interpubic disc (Wang et al, 2021) and collagen catabolism in the pubic symphysis of mammals. High relaxin levels promote reduced collagen content through collagen degradation by activating the collagenolytic system (Samuel et al, 1998).…”

Peripartum Pubic Symphysis Diastasis—Practical Guidelines

“…Most specialists associate the cause of this condition with the activity of relaxin, which, in combination with other hormones, causes relaxation of the ligaments within the pelvic girdle. It has been proved that the release of relaxin does not correlate with the degree of dilation of the symphysis; however, disturbed internal regulation of its secretion with simultaneous relaxation of the ligamentous apparatus can be associated with postpartum diastasis of the pubic symphysis [ 11 , 12 ]. The role of relaxin is not only correlated to relaxation as a possible natural antifibrotic substance, but concentrations of serum relaxin may be investigated as a potential marker of pubic symphysis diastasis [ 11 ].…”