Role of procalcitonin, Il-6 and C- reactive protein in suspected cases of sepsis

Sharma, S. N.; Duggal, Nandini

doi:10.4103/ijpm.ijpm_762_18

Cited by 8 publications

(6 citation statements)

References 20 publications

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“…Lastly in case of IL-6, when compared to blood culture in terms of sensitivity and specificity it was found to be 54% and 77% respectively and similar findings have been reported by Al-Zahrani et al, (23) and Rashwan et al, (15) On analyzing the observations in this study, it was found that there is a higher positive correlation and regression coefficients in PCT level and CRP level among those neonates that died during this study which indicates that there is progressive association between the two markers as observed in overall cases wherever CRP level was found to be increased, the PCT level in body is also elevated more significantly these findings that can be attributed with observations by Hasan et al, (24) and Rashwan et al, (15). Similar findings were observed by Sharma et al, (25) where IL-6 and CRP levels were correlated with the high PCT levels in blood culture positive cases (p value <0.05). In our study it was observed that procalcitonin is a better biological maker than CRP and IL-6 when prediction of infection is assessed in neonates, these findings are in accordance with Rashwan et al, (15) and Morad et al, (18).…”

Section: Discussionsupporting

confidence: 87%

Assessment of C-reactive protein, procalcitonin and interlukin-6 as diagnostic aid for neonatal infections at a tertiary care center

et al. 2021

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Introduction and Aim: Neonatal infections are the leading cause of mortality among neonates after prematurity. The importance determining biological markers to be used as a diagnostic test to detect neonatal infections the in early stage of the disease is a challenge. The purpose of this study was to evaluate the usefulness & sensitivity of various serological markers such as serum Procalcitonin, C-reactive protein and chemokine IL-6 for diagnosis of neonatal infections leading to sepsis in new born infants. Materials and Methods: This cross-sectional study was carried out among newborns admitted in neonatal intensive care unit (NICU) and meeting the selection criteria. Samples were collected for blood culture and ELISA was performed for detection of CRP, PCT & IL-6. Results: A total of 300 newborns were included in this study from NICU of which 132 (44%) neonates was found to be blood culture positive. The most frequently isolated organisms were Klebsiella pneumoniae (26.5%), followed by Candida albicans (18.1%). In case of confirmed neonatal sepsis, significant higher levels of CRP, PCT and IL-6 were detected than in cases of probable sepsis. Serum procalcitonin levels exhibit highest sensitivity and specificity as 65.91% and 91.67% respectively. Conclusion: Serum procalcitonin has better diagnostic utility in terms of biological marker for the diagnosis of neonatal infections than C- reactive protein and Interleukin-6.

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Section: Discussionsupporting

confidence: 87%

Assessment of C-reactive protein, procalcitonin and interlukin-6 as diagnostic aid for neonatal infections at a tertiary care center

et al. 2021

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“…Bacterial sepsis is an infectious disease that, if not controlled and treated in a timely manner, can develop into severe sepsis, posing a serious threat to the life and health of patients [ 1 ]. In recent years, the incidence of this disease has not only increased gradually but also the morbidity and mortality rate has become high, with 500,000 bacterial sepsis patients losing their lives worldwide every year [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

C-Reactive Protein, Procalcitonin, and a Novel Pathogenesis and Therapeutic Target of Thrombocytopenia in Sepsis

2022

Emergency Medicine International

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Objective. The aim of the study is to analyze the clinical characteristics, pathogen distribution, and drug sensitivity information of adult sepsis, and to provide reference for empirical clinical use; to explore the relationship between C-reactive protein (CRP) and calcitonin (PCT) The clinical value in the diagnosis of adult sepsis. Methods. We collected 455 cases of hospitalized patients with positive blood culture, including 352 cases with sepsis and 103 cases without sepsis; 1609 cases of hospitalized patients with suspected infection and negative blood culture, including 287 cases of sepsis, and 518 cases of non-infectious systemic inflammatory response syndrome (SIRS) and 804 cases of local infection. Age, gender, route of admission, admission status, CRP, PCT, and white blood cell (WBC) levels were collected from the patients. The differences between the factors were statistically analyzed, and the receiver operating characteristic curve (ROC curve) was plotted to obtain the optimal cut-off values of CRP and PCT and their area under the curve (AUC), and to compare the CRP, PCT and PCT, and the CRP + PCT tandem to diagnose sepsis sensitivity and specificity. Results. (1) 387 pathogenic strains were isolated from blood cultures of patients with sepsis, 71.06% Gram-negative, 26.87% Gram-positive and 2.07% fungi. (2) Among Gram-positive bacteria, Staphylococcus aureus was 87.5% resistant to penicillin and sensitive to vancomycin, milantropine, and teicoplanin; among Gram-negative bacteria, Escherichia coli was resistant to piracillin The resistance rate was 73.1%, fully susceptible to viraemia (100%) and resistant to imipenem, amikacin, and lacillin/tazole. (3) Among patients with positive blood cultures, CRP and PCT levels were higher in patients with sepsis than in those without sepsis. Pairwise comparison of ROC curves showed that the diagnostic value of PCT was greater than that of CRP ( P = 0.016 ). Conclusion. CRP and PCT have a good reference value for diagnosis of sepsis patients and determination of the degree of infection in septic patients, especially PCT is more valuable for diagnosis of sepsis.

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“…[ 27 ] quoted that serum PCT and CRP values in sepsis cases, severe sepsis, and septic shock were higher significantly ( P < 0.01) and PCT superior to CRP in identification and to evaluate severity of sepsis. Sharma and Duggal[ 28 ] in their study depicted that PCT along with CRP is a better diagnostic tool for sepsis. Tian et al .…”

Section: Discussionmentioning

confidence: 99%

Sepsis screening of neonatal abdominal surgery and its outcomes

Kumar

Addagatla

Jaglan

et al. 2022

J Indian Assoc Pediatr Surg

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Aim: The aim of this study was to evaluate the early indicators of sepsis (sepsis screening) and their statistical correlation with sepsis in neonatal abdominal surgery. Materials and Methods: A prospective observational study was performed on thirty consecutive neonate cases aged between 0 and 28 days with surgical abdomen at the Paediatric Surgery Department, ABVIMS and Dr. Ram Manohar Lohia Hospital, New Delhi. The study duration was 18 months. Septic screening was done in all neonates on day 0, 1, 3, 7, and 14 days of surgery with serum procalcitonin, C-reactive protein, total leukocyte count, immature/total neutrophil ratio, and microerythrocyte sedimentation rate. A septic screening-positive patient (three or more positive parameters out of five) was correlated with sepsis and analysis was done. Results: A total of 30 neonates of abdominal surgical cases were included consequently, out of which 56.7% ( n = 17) were male and 43.3% ( n = 13) were female. Maximum cases were of congenital diaphragmatic hernia 20% ( n = 6) and then anorectal malformation 16.7% ( n = 5). About 70% of neonates were sepsis screening positive. Fifty percentage of neonates were diagnosed to have sepsis on the clinical or laboratory findings, so sensitivity and specificity of sepsis screening were 93.33% and 40%, respectively. There was total 30% mortality in this study. Conclusion: Sepsis screening is an early marker of sepsis, which can be used to help in early detection of neonatal surgical sepsis and timely intervention that can lead to decrease mortality and morbidity in neonatal surgery.

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Role of procalcitonin, Il-6 and C- reactive protein in suspected cases of sepsis

Cited by 8 publications

References 20 publications

Assessment of C-reactive protein, procalcitonin and interlukin-6 as diagnostic aid for neonatal infections at a tertiary care center

Assessment of C-reactive protein, procalcitonin and interlukin-6 as diagnostic aid for neonatal infections at a tertiary care center

C-Reactive Protein, Procalcitonin, and a Novel Pathogenesis and Therapeutic Target of Thrombocytopenia in Sepsis

Sepsis screening of neonatal abdominal surgery and its outcomes

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