Role of Procalcitonin and Interleukin-6 in Predicting Cancer, and Its Progression Independent of Infection

Chaftari, Anne-Marie; Hachem, Ray; Reitzel, Ruth; Jordan, Mary Ann; Jiang, Ying; Yousif, Ammar; Garoge, Kumait; Deshmukh, Poonam; Hamal, Zanaib Al; Jabbour, Joseph; Hanania, Alexander N.; Raad, Sammy; Mohamed, Jamal A.; Raad, Issam

doi:10.1371/journal.pone.0130999

Cited by 39 publications

(40 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 36 The utility of PCT to discriminate between fever caused by infection and inflammation has been intensively studied in cancer patients – especially in those with solid tumors and hematological diseases ( Figure 1B ). 37 As far as cancer patients with solid tumors and without neutropenia are concerned, conclusions about the utility of PCT measurement considerably differ. Some reports claim that PCT can help in differentiating between infection and no infection, but others state that its role is limited and should be interpreted with caution.…”

Section: Pct In Cancer Patientsmentioning

confidence: 99%

Utility of blood procalcitonin concentration in the management of cancer patients with infections

Durnaś¹,

Wątek²,

Wollny³

et al. 2016

OTT

View full text Add to dashboard Cite

Diagnosis of infections in cancer patients is usually problematic since differentiating between infection and fever of unknown origin is often a considerable clinical challenge. In general, increase concentration of blood procalcitonin (PCT) is associated with severe bacterial infection. PCT with an optimal cutoff level of 0.5 ng/mL seems to be the most helpful biochemical parameter in detecting severe infections, mainly bloodstream infection, in patients with hematological cancers. In all clinical situations, the elevated level of PCT should be carefully analyzed, always with a thorough physical examination and an appropriate microbiological assessment.

show abstract

Section: Pct In Cancer Patientsmentioning

confidence: 99%

Utility of blood procalcitonin concentration in the management of cancer patients with infections

Durnaś¹,

Wątek²,

Wollny³

et al. 2016

OTT

View full text Add to dashboard Cite

show abstract

“…There are identified germs that stimulate higher levels of PCT, as for example E. coli, Proteus spp, and there are also differences according to the infectious focus 15,28,29 . In our study, the reduced number of cases of fungal infection does not allow us issuing conclusions regarding PCT and these microbial agents.…”

Section: Discussionmentioning

confidence: 99%

Procalcitonin as early predictor of bacteremia in critically ill neutropenic patients

Marín¹,

Basantes²,

Caballero³

et al. 2022

GAMO

View full text Add to dashboard Cite

Background: Procalcitonin (PCT) could predict the presence of bacteremia in critically ill patients with febrile neutropenia. The objective was to determine the predictive value of PCT in the diagnosis of bacteremia and its ability to differentiate between gram-negative and gram-positive organisms. Methods: Retrospective cohort study conducted at the Oncology Hospital "Solón Espinosa Ayala, " Quito-Ecuador, which included patients who were admitted with febrile neutropenia to intensive therapy. PCT values were evaluated at admission together with blood culture samples, from 2010 to 2016. Results: The association between PCT levels and the diagnosis of bacteremia was investigated in 117 patients. PCT demonstrated bacteremia discrimination with a point of cut of 15.5 ng/ml and an area under the curve (AUC) of 0.76. The concentration of PCT in patients with bacteremia by gram-negative germs was higher compared with patients with bacteremias by gram-positive germs, 26 vs. 7.1 ng/ml (p = 0.001). Values > 26.8 ng/ml predict bacteremia by Gram-negative bacilli (AUC: 0.81). Conclusions: A cutoff value of PCT > 15.5 ng/ml is a predictor of bacteremia (AUC: 0.76) and values > 26.8 ng/ml predict bacteremia by gram-negative bacilli (AUC: 0.81).

show abstract

“…Existen gérmenes identificados que estimulan mayores niveles de PCT, como por ejemplo: E. coli, Proteus spp y también diferencias de acuerdo con el foco infeccioso 15,28,29 . En nuestro estudio el número reducido de casos de infecciones micóticas no permite emitir conclusiones relacionadas con la PCT y estos agentes microbianos.…”

Section: Discussionunclassified

Procalcitonina como predictor temprano de bacteriemia en pacientes neutropénicos críticamente enfermos

Marin¹,

Unigarro²,

Basantes³

et al. 2020

GAMO

View full text Add to dashboard Cite

Artículo originAl resumen Antecedentes: La procalcitonina (PCT) podría predecir la presencia de bacteriemia en pacientes críticos con neutropenia febril. El objetivo del estudio fue determinar el valor predictivo de la PCT en el diagnóstico de bacteriemia y su capacidad de diferenciar gérmenes gramnegativos y grampositivos. Métodos: Estudio de cohorte retrospectivo realizado en el Hospital Oncológico Solón Espinosa Ayala, Quito-Ecuador, que incluyó todos los pacientes adultos que ingresaron con neutropenia febril a la terapia intensiva. Se evaluaron los valores de PCT al ingreso junto con muestras de hemocultivos, desde el año 2010 al 2016. resultados: En 117 pacientes se investigó la asociación entre niveles de PCT y el diagnóstico de bacteriemia, la PCT demostró discriminación de bacteriemia, punto de corte de 15.5 ng/ml y un área bajo la curva (AUC) de 0.76 en la curva ROC (curva operador-receptor). La concentración de PCT en pacientes con bacteriemia por gérmenes gramnegativos fue mayor comparada con pacientes con bacteriemias por gérmenes grampositivos, 26 vs. 7.1 ng/ml (p = 0.001). Valores mayores a 26.8 ng/ml predicen bacteriemia por bacilos gramnegativos (AUC: 0.81). conclusiones: En pacientes neutropénicos febriles críticos, un valor de corte de PCT mayor a 15.5 ng/ml es un predictor de bacteriemia (AUC: 0.76) y valores mayores a 26.8 ng/ml predicen bacteriemia por bacilos gramnegativos (AUC: 0.81).

show abstract

Role of Procalcitonin and Interleukin-6 in Predicting Cancer, and Its Progression Independent of Infection

Cited by 39 publications

References 28 publications

Utility of blood procalcitonin concentration in the management of cancer patients with infections

Utility of blood procalcitonin concentration in the management of cancer patients with infections

Procalcitonin as early predictor of bacteremia in critically ill neutropenic patients

Procalcitonina como predictor temprano de bacteriemia en pacientes neutropénicos críticamente enfermos

Contact Info

Product

Resources

About